A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza

用于传染性鼻炎的“Goldilocks”家禽减毒活疫苗

• 批准号: LP210301365
• 负责人: Prof Michael Jennings
• 金额: $ 44.35万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-07 至 2027-07-06
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210301365
• 关键词: Goldilocks; live; attenuated; poultry; vaccine

This project aims to develop a safe and effective vaccine for Infectious Coryza using a live-attenuated vaccine approach. Infectious coryza is an acute respiratory disease of chickens and is caused by the bacterial pathogen, Avibacterium paragallinarum. Infectious Coryza can be controlled by appropriate biosecurity practises and this has been successful in the Australian context to date. However, in the USA, Europe and other equatorial regions, infectious Coryza remains an unsolved problem. The expected outcome of this project is a cross-serovar protective vaccine to prevent infectious coryza for use in endemic countries and to act as a biosecurity measure to protect Australia's poultry industry against an incursion of this disease.

本项目旨在使用减毒活疫苗方法开发一种安全有效的传染性鼻炎疫苗。鸡传染性鼻炎是一种急性呼吸道传染病，由副呼吸道禽杆菌引起。传染性鼻炎可以通过适当的生物安全措施加以控制，迄今为止，这在澳大利亚是成功的。然而，在美国，欧洲和其他赤道地区，传染性鼻炎仍然是一个未解决的问题。该项目的预期成果是一种交叉血清型保护性疫苗，用于流行国家预防传染性鼻炎，并作为一种生物安全措施，保护澳大利亚家禽业免受这种疾病的侵袭。