Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity

经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控

基本信息

  • 批准号:
    10610948
  • 负责人:
  • 金额:
    $ 56.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary Behavioral states such as sleep and wake profoundly affect the patterns of activity and neuromodulatory tone within neocortical circuits, but the function of these state changes on learning and experience-dependent plasticity remain controversial. It has been postulated that wake is when Hebbian mechanisms are engaged, while sleep serves to homeostatically “renormalize” synaptic strengths/firing rates that were perturbed by experience-dependent changes in the waking state. We study the homeostatic plasticity mechanisms that stabilize firing rates and circuit function within primary visual cortex (V1), and can track this process in freely behaving rodents. Perturbing firing through monocular visual deprivation (MD) initially suppresses firing (1- 2d MD), but firing rates then rebound to control levels over a 2 d period despite continued MD. Further, we can perturb firing in the other direction using an MD followed by eye re-opening (ER) paradigm, and observed that firing rates are potentiated by ER and again slowly return to baseline values. This ‘firing rate homeostasis’ is accomplished in part through synaptic scaling up or down of excitatory synapses onto pyramidal neurons within V1. We can follow this process in freely behaving animals cycling between natural bouts of sleep and wake, to directly determine when the homeostatic restoration of firing occurs. In the last funding period we made the surprising discovery that upward and downward firing rate homeostasis are oppositely regulated by sleep and wake states: upward occurs gradually during each bout of active wake and is suppressed by sleep, while downward is enabled by sleep and suppressed by wake. Our work reveals that sleep and wake states are critically important for gating homeostatic plasticity, and act to segregate upward and downward homeostatic processes into distinct behavioral states. How this is accomplished mechanistically is entirely unknown, as is the function this segregation might serve. Here we propose to determine the features of waking/sleeping states that enable/suppress firing rate homeostasis, and to test whether the underlying synaptic plasticity mechanisms are themselves directly gated by sleep and wake. Finally, to gain insight into the behavioral/functional consequences of this gating, we propose to test how sleep and wake orchestrate Hebbian and homeostatic plasticity within V1 during a vision-dependent learning task. These experiments promise to illuminate fundamental features of visual cortical physiology, and to shed light on the function of sleep and wake states in coordinating synaptic plasticity during learning.
项目总结

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Stability of neocortical synapses across sleep and wake states during the critical period in rats.
  • DOI:
    10.7554/elife.66304
  • 发表时间:
    2021-06-21
  • 期刊:
  • 影响因子:
    7.7
  • 作者:
    Cary BA;Turrigiano GG
  • 通讯作者:
    Turrigiano GG
Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics.
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GINA G TURRIGIANO其他文献

GINA G TURRIGIANO的其他文献

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{{ truncateString('GINA G TURRIGIANO', 18)}}的其他基金

Mechanisms and Function of Firing Rate Homeostasis in Cortical Circuits
皮层回路放电率稳态的机制和功能
  • 批准号:
    10891888
  • 财政年份:
    2023
  • 资助金额:
    $ 56.49万
  • 项目类别:
Mechanisms and Function of Firing Rate Homeostasis in Cortical Circuits
皮层回路放电率稳态的机制和功能
  • 批准号:
    10604278
  • 财政年份:
    2019
  • 资助金额:
    $ 56.49万
  • 项目类别:
Mechanisms and function of firing rate homeostasis in cortical circuits
皮质回路中放电率稳态的机制和功能
  • 批准号:
    9923773
  • 财政年份:
    2019
  • 资助金额:
    $ 56.49万
  • 项目类别:
Mechanisms and function of firing rate homeostasis in cortical circuits
皮质回路放电率稳态的机制和功能
  • 批准号:
    10391451
  • 财政年份:
    2019
  • 资助金额:
    $ 56.49万
  • 项目类别:
Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity
经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控
  • 批准号:
    9767198
  • 财政年份:
    2017
  • 资助金额:
    $ 56.49万
  • 项目类别:
Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity
经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控
  • 批准号:
    10209082
  • 财政年份:
    2017
  • 资助金额:
    $ 56.49万
  • 项目类别:
Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity
经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控
  • 批准号:
    9546749
  • 财政年份:
    2017
  • 资助金额:
    $ 56.49万
  • 项目类别:
Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity
经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控
  • 批准号:
    9380563
  • 财政年份:
    2017
  • 资助金额:
    $ 56.49万
  • 项目类别:
Gating of Firing Rate Homeostasis by Sleep and Wake States During Experience-Dependent Plasticity
经验依赖性可塑性期间睡眠和清醒状态对放电率稳态的门控
  • 批准号:
    10396620
  • 财政年份:
    2017
  • 资助金额:
    $ 56.49万
  • 项目类别:
Synaptic Homeostasis in Neocortical Neurons and Circuits
新皮质神经元和回路的突触稳态
  • 批准号:
    9111079
  • 财政年份:
    2015
  • 资助金额:
    $ 56.49万
  • 项目类别:

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