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Patient-Directed Computational Analysis of Atrial Fibrillation

患者导向的心房颤动计算分析

基本信息

批准号：
10610778
负责人：
WOUTER-JAN RAPPEL
金额：
$ 57.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-01-12 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610778
关键词：
3-Dimensional Ablation Acute Affect Algorithms American Arrhythmia Atrial Fibrillation Automobile Driving Blinded Caring Characteristics Chronic Clinical Clinical Trials Complex Computational Technique Computer Analysis Computer Models Computer Simulation Data Development Digital Computers Electrophysiology (science)Extinction Freedom Frequencies Funding Geometry Goals Health Heart Atrium Heart failure Hour Left Maintenance Maps Mediating Meta-Analysis Modeling Morbidity - disease rate Observational Study Outcome Patients Pattern Persons Pharmacotherapy Phase Physics Procedures Public Health Pulmonary veins Registries Reporting Source Stroke Techniques Testing Therapeutic Time Tissues Translating Work effective therapy improved indexing individual patient interest mortality novel novel therapeutics open source patient registry prospective test randomized trial simulation source localization spatiotemporal success therapy development

项目摘要

Patient-Directed Computational Analysis of Atrial Fibrillation Project Summary Atrial fibrillation (AF) is the most common arrhythmia and is a rapidly-growing public health problem that currently affects over 30 million people world-wide and more than 5 million people in the US. If left untreated, AF leads to an increase in stroke, heart failure and mortality. Unfortunately, the mechanisms that maintain AF remain poorly understood, hindering further improvement of current therapy strategies. Recent studies, however, have revealed that AF may be driven by rotational or focal sources and that targeting these sources using localized ablation can result in promising long-term outcomes. Due to our incomplete understanding of AF, however, this targeted ablation approach is not always successful. This project will test the novel hypothesis that AF is sustained by localized rotational and focal sources with different size and temporal stability and that, after these sources are removed, termination is not immediate but is maintained by non-local mechanisms. We will address this hypothesis using a combined computational/clinical approach that employs advanced multiscale computational techniques and state-of-the-art clinical mapping. The project will 1) quantify AF organization using patient-specific geometries; 2) determine whether some rotational or focal sources are more important than others; 3) test possible causes of AF maintenance and termination using patient-specific digital computer models. We will use data from our unique and large patient registry, currently totaling >500 patients. This project is significant because it will establish a deeper understanding of AF and might reveal novel mechanisms of AF maintenance. Our results can be translated directly to practice and may enable the development of better treatment options.

房颤患者导向的计算分析项目摘要心房颤动（AF）是最常见的心律失常，目前影响全球3000多万人的公共卫生问题在美国有超过500万人。如果不治疗，AF会导致中风、心力衰竭和死亡率增加。不幸的是，维持AF仍然知之甚少，阻碍了当前治疗策略。然而，最近的研究表明，房颤可能是由旋转或焦点源驱动，并以这些源为目标，局部消融可以产生有希望的长期结果。由于我们然而，对房颤的了解不全面，这种靶向消融方法并不总是成功的。该项目将测试新的假设，即房颤是持续的局部具有不同大小和时间稳定性的旋转和焦点源，在这些源被移除之后，终止不是立即的，而是维持的非本地机制。我们将使用组合的计算/临床方法，采用先进的多尺度计算技术和最先进的临床绘图。该项目将1）量化AF 使用患者特定的几何结构的组织; 2）确定是否一些旋转源或焦点源比其他源更重要; 3）测试可能使用患者专用数字计算机分析房颤维持和终止的原因模型我们将使用来自我们独特的大型患者登记处的数据，超过500名患者。这个项目意义重大，因为它将建立一个更深入的了解AF 并可能揭示房颤维持的新机制。我们的研究结果可以直接转化为实践，可以使发展更好治疗方案。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High-order finite element methods for cardiac monodomain simulations.

DOI：
10.3389/fphys.2015.00217
发表时间：
2015
期刊：
Frontiers in physiology
影响因子：
4
作者：
Vincent KP;Gonzales MJ;Gillette AK;Villongco CT;Pezzuto S;Omens JH;Holst MJ;McCulloch AD
通讯作者：
McCulloch AD

To the Editor- On the deformation and interpolation of phase maps.

致编辑 - 关于相位图的变形和插值。