Pandemic Preparedness: Biocontainment Facility Upgrade and Integration at UTMB/Galveston National Laboratory

流行病防范：UTMB/加尔维斯顿国家实验室的生物防护设施升级和集成

基本信息

批准号：
10611097
负责人：
Gary Kobinger
金额：
$ 713.18万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611097
关键词：
2019-nCoV Address Africa African Air Algorithms American Type Culture Collection Animals Antigens Antiviral Agents Applied Research Arboviruses Area Automation Award Basic Science Biomedical Research Biotechnology Bioterrorism Bunyavirales COVID-19 COVID-19 pandemic Carbon Dioxide Cells Centers for Disease Control and Prevention (U.S.)Cessation of life Clinical Research Clinical Sciences Collaborations Collection Communicable Diseases Communication Communities Complex Computer Security Containment Core Facility Coronavirus Country Culicidae Dangerousness Data Storage and Retrieval Department of Defense Development Diagnosis Diagnostic Differential Diagnosis Disease Disease Outbreaks Disease Vectors Drainage procedure Duct (organ) structure Ebola Ebola Vaccines Ebola virus Educational process of instructing Electronics Emergency Situation Emerging Communicable Diseases Ensure Environment Environmental Health Epidemic Equipment Evaluation Exercise Faculty Family Family Picornaviridae Filovirus Financial Support Fire - disasters Flaviviridae Foundations Freezing Funding Future Goals Government HIV Home Hospitals Human Human Resources Immunity Infection Infectious Agent Infectious Disease Immunology Infectious Diseases Research Influenza A Virus, H1N1 Subtype Influenza A virus Information Technology Infrastructure Institutes Institution International Investigation Joints Journals Laboratories Laboratory Research Lead Leadership Learning Letters Licensure Maintenance Malaria Marburgvirus Measures Medical Medical Research Medical Staff Middle East Respiratory Syndrome Mission Modeling Modernization Modification National Institute of Allergy and Infectious Disease Nature Nurses Paramyxovirus Pathogenesis Pathogenicity Pharmacologic Substance Police Positioning Attribute Prevention Prevention approach Principal Investigator Privatization Procedures Professional Practice Public Health Publications Publishing RNA RNA Viruses Reader Readiness Reagent Recording of previous events Regulation Reporting Research Research Design Research Institute Research Personnel Research Project Grants Role Running Safety Science Scientist Sea Security Services Ships Side Structure Support System System Systems Integration Techniques Testing Texas Therapeutic Therapeutic Monoclonal Antibodies Ticks Time Training Training and Education Translating Translational Research Treatment Efficacy Tropical Disease United States United States Food and Drug Administration United States National Institutes of Health Universities Vaccine Research Vaccines Vector-transmitted infectious disease Veterinarians Vial device Viral Virus Virus Diseases Washington West Nile virus Work World Health Organization Writing ZIKA Zaire Ebola virus Zoonoses animal model development animal resource animal rule antigen diagnostic base bench to bedside biocontainment facility biodefense biopharmaceutical industry biosafety level 4 facility biosecurity chikungunya combat communication device cyber security diagnostic tool drug candidate drug testing end of life exhaust experience firewall good laboratory practice improved infectious disease treatment interdisciplinary approach laboratory experience medical countermeasure meetings mortality multidisciplinary next generation operation pandemic disease pandemic influenza pandemic preparedness pathogen practical application professional atmosphere public health emergency repository research and development research facility respiratory virus response screening statistics therapeutic development therapeutically effective transmission process vaccine development vector-borne ventilation virtual virus development weapons

项目摘要

PROJECT SUMMARY/ABSTRACT Toward maintaining and improving pandemic preparedness, we propose value-added facility upgrades that better integrate the high-containment communities at the University of Texas Medical Branch (UTMB), Galveston. UTMB laboratories integrate operations through joint-facility management, usage, and collaborations that include educating the next generation of research scientists and medical staff. The UTMB community contains the Robert E. Shope Laboratory (Shope)—the first full-sized BSL-4 facility within a university in the United States, a structurally separate high-containment Galveston National Laboratory (GNL), and BSL3 laboratories of Mary Moody Northen Pavilion (MMNP). Each facility supports multiple experienced, published, and governmentally-funded investigators researching pathogens with pandemic potential, as well as facilitating biomedical research of vaccines and therapeutics. Our corpus of researchers includes 31 experts in one or more of six out of the seven RNA viruses of focus by NIAID toward Pandemic Preparedness. The requested financial support will enhance facility capabilities and security within an integrated system of services and operational functions that support the mandate of the GNL within the UTMB high-containment community. We propose to enhance integration of systems to provide a comprehensive protection of all UTMB high-containment facilities against cyberattack, while improving workflow, biosafety, biosecurity, and training capacities through modernization of specific antiquated high-containment areas that are also essential to pandemic responsivity. Of priority is to upgrade equipment and supportive infrastructure utilized in high-containment RNA viral research reaching “end-of-life” (EOL) or “end-of-service” (EOS), prior to experiencing difficulties procuring parts or having stoppage resulting in lost time, funds, and mitigating preparedness. Additionally, we will remedy specific infrastructural shortcomings to improve facility operations. Furthermore, as a leader in teaching the future investigators of high-consequence pathogens, the GNL proposes to upgrade a training area to better reflect the actual BSL4 environment. We will meet these goals through three Aims: Aim 1: Integrate cybersecurity systems under the GNL isolated protection, while modernizing safety and security of virtual and physical structures of UTMB high-containment facilities. Aim 2: Modernize facility and equipment of integrated usage among UTMB’s research community directly in support of BSL3 and BSL4 RNA research of viruses with high pandemic or weaponization potential. Aim 3: Implement pandemic preparedness toward effective future strategic response capacity. Ultimately, modernizations and integrations of systems, operations, and training will better position UTMB to contribute as a global research leader in discovery and development of solutions against high- consequence pathogens. This proposal is framed to provide enhanced security and capacities to further support our roles as collaborator, reference center and repository, institutional model, and trainer toward strategic implementation of a global pandemic preparedness.

项目摘要/摘要为了维持和改善大流行的准备，我们提出了增值设施的升级更好地整合了德克萨斯大学医学分公司（UTMB）的高控制社区加尔维斯顿。 UTMB实验室通过联合实力管理，使用和协作整合了运营这包括教育下一代研究科学家和医务人员。 UTMB社区包含Robert E. Shop Laboratory（Shope），这是大学中第一个全尺寸的BSL-4工厂美国，一个在结构上独立的高范围加尔维斯顿国家实验室（GNL）和BSL3 玛丽·穆迪·诺森馆（MMNP）的实验室。每个设施都支持多种经验，已发布，政府资助的研究人员研究具有大流行潜力的病原体，并促进疫苗和治疗的生物医学研究。我们的研究人员包括31位或多个专家 Niaid朝向大流行准备的七个RNA病毒中的六个。要求的财务支持将在集成的服务系统和运营系统中增强设施功能和安全性支持在UTMB高端界内GNL授权的功能。我们建议增强系统的集成，以提供对所有UTMB高级维护设施的全面保护反对网络攻击，同时改善工作流程，生物安全，生物安全性和培训能力对大流行反应也至关重要的特定过时的高关键区域的现代化。优先级是升级用于高控制RNA病毒研究的设备和支持的基础设施在遇到难度或拥有零件之前，达到“寿命”（EOL）或“服务终止”（EOS）（EOS）停工会导致时间浪费，资金和缓解准备。此外，我们会记住具体的基础设施缺点以改善设施运营。此外，作为教导未来的领导者高导病原体的研究者，GNL提出升级训练区的建议，以更好地反映实际BSL4环境。我们将通过三个目标实现这些目标：目标1：整合网络安全系统在GNL孤立的保护下，同时将虚拟和物理结构的安全性和安全性现代化 UTMB高管设施。 AIM 2：将UTMB的集成使用设备现代化设备现代化直接支持大流行或大流行病毒的BSL3和BSL4 RNA研究武器化潜力。目标3：实施大流行准备，以有效的未来战略反应容量。最终，系统，操作和培训的现代化和整合将更好地定位 UTMB成为发现和开发解决方案的全球研究负责人后果病原体。该建议是构建的，以提供增强的安全性和能力以进一步支持我们作为合作者，参考中心和存储库，机构模型和培训师的角色实施全球大流行准备。