A Bedside-to-Bench Approach to Pandemic Preparedness

流行病防范的从床边到工作台的方法

• 批准号: 10611759
• 负责人: KENNETH W. BAYLES
• 金额: $ 390.7万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611759
• 关键词: Address; Animal Model; COVID-19 pandemic; Cell Separation; Cell physiology; Clinical; Clinical Data; Clinical Research; Communicable Diseases; Containment; Decontamination; Development; Diagnostic; Disease; Ebola; Enhancement Technology; Environment; Equipment; Event; Exposure to; Faculty; Fostering; Future; Goals; Human Resources; Individual; Infection; Infectious Agent; Infectious Diseases Research; Infrastructure; Investments; Laboratories; Laboratory Research; Medical center; Medicine; Microscopy; Modernization; Nebraska; Pathogenesis; Pathogenicity; Patients; Play; Quarantine; Research; Research Personnel; Role; Sampling; Standardization; Technology; Universities; Update; Work; arm; bench to bedside; biocontainment facility; biosecurity; diagnostic assay; emerging pathogen; high efficiency particulate air filter; improved; insight; interoperability; laboratory development; novel diagnostics; novel therapeutics; novel vaccines; pandemic disease; pandemic preparedness; pathogen; recruit; research facility; response; synergism; therapeutic development; vaccine development

The clinical capabilities of the University of Nebraska Medical Center (UNMC) and its clinical partner, Nebraska Medicine (NM), played vital roles in the treatment of U.S. citizens infected with Ebola in 2014 and the early response to the COVID-19 pandemic. While the presence of the National Quarantine Unit (NQU) and the Nebraska Biocontainment Unit (NBU) on campus provided UNMC researchers with some of the earliest access to individuals exposed to infectious agents (in the NQU), as well as those who begin to develop disease (in the NBU), we recognized a key gap in our capabilities is the lack of modern technologies within our high- containment spaces required to gain greater insights into the pathogenic mechanisms utilized by new and emerging pathogens. Therefore, the overall goal of this proposed project is to modernize our high-containment research laboratories to maximize their research potential and to leverage our clinical expertise to foster research on vaccine and therapeutic development. This will be achieved in two ways: First, we will improve our biocontainment infrastructure within key biocontainment research facilities in a way that increases our capacity to conduct research on high-consequence pathogens, maximizes synergy between the various biocontainment laboratories, and increases biosecurity. Second, we will invest in the modern technologies needed in our BSL-3 and ABSL-3 laboratories to conduct cutting-edge studies on new and emerging pathogens and to address critical questions related to disease pathogenesis. Upon completion, these improvements will foster much greater synergy between the clinical and research arms of UNMC and NM, leveraging early access to clinical data/samples to streamline research into disease pathogenesis, and to accelerate the development of new vaccines and therapeutics during future pandemics.

内布拉斯加大学医学中心 (UNMC) 及其附属机构的临床能力 临床合作伙伴 Nebraska Medicine (NM) 在美国公民的治疗中发挥了至关重要的作用 2014 年感染埃博拉病毒以及对 COVID-19 大流行的早期反应。虽然 国家检疫单位 (NQU) 和内布拉斯加州生物防护单位 (NBU) 的存在 校园内为 UNMC 研究人员提供了一些最早接触暴露个体的机会 传染源（在 NQU 中）以及那些开始患病的人（在 NBU 中）， 我们认识到我们能力的一个关键差距是我们的高科技领域缺乏现代技术。 需要更深入地了解所利用的致病机制的收容空间 新出现的病原体。因此，该项目的总体目标是实现现代化 我们的高密闭研究实验室最大限度地发挥其研究潜力并利用 我们的临床专业知识促进疫苗和治疗开发的研究。这将是 通过两种方式实现：首先，我们将在关键范围内改善我们的生物防护基础设施 生物防护研究设施，以提高我们进行研究的能力 高后果病原体，最大限度地发挥各种生物防护之间的协同作用 实验室，并提高生物安全。其次，我们将投资所需的现代技术 在我们的 BSL-3 和 ABSL-3 实验室中对新兴的领域进行前沿研究 病原体并解决与疾病发病机制相关的关键问题。完成后， 这些改进将促进临床和研究部门之间更大的协同作用 UNMC 和 NM，利用早期获取临床数据/样本来简化研究 疾病发病机制，并加速新疫苗和疗法的开发 在未来的大流行期间。