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A Bedside-to-Bench Approach to Pandemic Preparedness

流行病防范的从床边到工作台的方法

基本信息

批准号：
10611759
负责人：
KENNETH W. BAYLES
金额：
$ 390.7万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611759
关键词：
Address Animal Model COVID-19 pandemic Cell Separation Cell physiology Clinical Clinical Data Clinical Research Communicable Diseases Containment Decontamination Development Diagnostic Disease Ebola Enhancement Technology Environment Equipment Event Exposure to Faculty Fostering Future Goals Human Resources Individual Infection Infectious Agent Infectious Diseases Research Infrastructure Investments Laboratories Laboratory Research Medical center Medicine Microscopy Modernization Nebraska Pathogenesis Pathogenicity Patients Play Quarantine Research Research Personnel Role Sampling Standardization Technology Universities Update Work arm bench to bedside biocontainment facility biosecurity diagnostic assay emerging pathogen high efficiency particulate air filter improved insight interoperability laboratory development novel diagnostics novel therapeutics novel vaccines pandemic disease pandemic preparedness pathogen recruit research facility response synergism therapeutic development vaccine development

项目摘要

The clinical capabilities of the University of Nebraska Medical Center (UNMC) and its clinical partner, Nebraska Medicine (NM), played vital roles in the treatment of U.S. citizens infected with Ebola in 2014 and the early response to the COVID-19 pandemic. While the presence of the National Quarantine Unit (NQU) and the Nebraska Biocontainment Unit (NBU) on campus provided UNMC researchers with some of the earliest access to individuals exposed to infectious agents (in the NQU), as well as those who begin to develop disease (in the NBU), we recognized a key gap in our capabilities is the lack of modern technologies within our high- containment spaces required to gain greater insights into the pathogenic mechanisms utilized by new and emerging pathogens. Therefore, the overall goal of this proposed project is to modernize our high-containment research laboratories to maximize their research potential and to leverage our clinical expertise to foster research on vaccine and therapeutic development. This will be achieved in two ways: First, we will improve our biocontainment infrastructure within key biocontainment research facilities in a way that increases our capacity to conduct research on high-consequence pathogens, maximizes synergy between the various biocontainment laboratories, and increases biosecurity. Second, we will invest in the modern technologies needed in our BSL-3 and ABSL-3 laboratories to conduct cutting-edge studies on new and emerging pathogens and to address critical questions related to disease pathogenesis. Upon completion, these improvements will foster much greater synergy between the clinical and research arms of UNMC and NM, leveraging early access to clinical data/samples to streamline research into disease pathogenesis, and to accelerate the development of new vaccines and therapeutics during future pandemics.

内布拉斯加大学医学中心（UNMC）的临床能力及其