Selenium metabolism in cold-induced adaptive thermogenesis
冷诱导适应性产热中的硒代谢
基本信息
- 批准号:10616992
- 负责人:
- 金额:$ 4.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdipocytesAdministrative SupplementBioinformaticsBrown FatCell DeathComplementDevelopment PlansDoctor of PhilosophyEducational workshopEnzymesExperimental DesignsGenesHispanicHistologyIronKnockout MiceMedicalMetabolismMicronutrientsMicroscopyOralParentsRecyclingResearchResearch TrainingRoleSeleniumThermogenesisTrainingUnderrepresented MinorityWritingadipocyte differentiationcareercareer developmentcollaborative environmentexperiencein vivomeetingsmouse modelparent grantprogramsresearch and developmentresponseselenocysteine lyaseselenoproteinskills
项目摘要
ABSTRACT
The studies proposed in this Administrative Supplement to parent grant DK128390 aim to promote the scientific
research and career development of Sydonie Swanson, a Postbaccalaureate candidate with a Hispanic heritage
seeking to gain research experience. The parent grant focuses on determining the role of selenium recycling in
regulating selenoprotein enzymes GPX1 and DIO2 in brown adipose tissue and how the recycling mechanism
contributes to cold-induced adaptive thermogenesis in vivo, using whole-body and brown adipocyte-specific
knockout mouse models of the selenium recycling enzyme selenocysteine lyase (SCLY). This Administrative
Supplement will complement these studies by pursuing these Research Aims: 1) To determine the role of
selenium and SCLY in the differentiation of brown adipocytes; and 2) To determine if treatment of pre-adipocytes
with selenium or the activity of SCLY controls the expression and activity of selenoprotein GPX4, impacting
responses to ferroptosis,
an iron-dependent cell death mechanism, in differentiated brown adipocytes. The
Research and Career Development Plan for Sydonie focuses on training technical (e.g., histology, microscopy,
gene editing, bioinformatics) and professional (e.g., experimental design, scientific writing, and oral
presentations) skills in a collaborative environment that will provide a robust research experience and favor her
successful inclusion in the medical workforce.
摘要
家长资助DK 128390的行政补充中提出的研究旨在促进科学研究
Sydonie Swanson的研究和职业发展,他是一名具有西班牙裔血统的学士后候选人
寻求获得研究经验。家长补助金的重点是确定硒回收的作用,
调节棕色脂肪组织中的硒蛋白酶GPX 1和DIO 2,
有助于体内冷诱导的适应性产热,使用全身和棕色脂肪细胞特异性
硒再循环酶硒代半胱氨酸裂解酶(SCLY)的敲除小鼠模型。这一行政
补充将通过追求这些研究目标来补充这些研究:1)确定
硒和SCLY在棕色脂肪细胞分化中的作用; 2)确定前脂肪细胞的处理是否
与硒或SCLY的活性控制硒蛋白GPX 4的表达和活性,影响
对铁凋亡的反应,
在分化的棕色脂肪细胞中,铁依赖性细胞死亡机制。的
悉尼的研究和职业发展计划侧重于技术培训(例如,组织学,显微镜,
基因编辑,生物信息学)和专业(例如,实验设计、科学写作和口头
演讲)技能在协作环境中,将提供一个强大的研究经验,并有利于她
成功融入医疗队伍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lucia Andreia Seale其他文献
Lucia Andreia Seale的其他文献
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{{ truncateString('Lucia Andreia Seale', 18)}}的其他基金
Selenium metabolism in cold-induced adaptive thermogenesis
冷诱导适应性产热中的硒代谢
- 批准号:
10186406 - 财政年份:2021
- 资助金额:
$ 4.81万 - 项目类别:
Selenium metabolism in cold-induced adaptive thermogenesis
冷诱导适应性产热中的硒代谢
- 批准号:
10713400 - 财政年份:2021
- 资助金额:
$ 4.81万 - 项目类别:
Selenium metabolism in cold-induced adaptive thermogenesis
冷诱导适应性产热中的硒代谢
- 批准号:
10396667 - 财政年份:2021
- 资助金额:
$ 4.81万 - 项目类别:
Selenium metabolism in cold-induced adaptive thermogenesis
冷诱导适应性产热中的硒代谢
- 批准号:
10579270 - 财政年份:2021
- 资助金额:
$ 4.81万 - 项目类别:
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