Aflatoxin exposure and hepatocellular carcinoma in Mexico
墨西哥的黄曲霉毒素暴露与肝细胞癌
基本信息
- 批准号:10614766
- 负责人:
- 金额:$ 8.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAflatoxin B1AflatoxinsAfrica South of the SaharaAlbuminsAlcoholsAmericasAreaAutomobile DrivingBiological MarkersBloodCancer BurdenCancer EtiologyCancer Research NetworkCentral AmericaCessation of lifeCharacteristicsClinicalCollaborationsCommunitiesCountryDataDiabetes MellitusEnvironmentEnvironmental HealthEnvironmental PollutionEpidemiologyEtiologyEvaluationExonsExposure toFaceFar EastFemaleFoodFosteringFutureGene MutationGeographyGuatemalaHBV and AflatoxinHealth SurveysHepatitis B PrevalenceHepatitis B VirusHepatitis C virusHigh PrevalenceHispanic PopulationsHospitalsImmigrantIncidenceInduced MutationInfectionInstitutionInternationalLiverLow PrevalenceMaizeMeasuresMetabolic syndromeMexican AmericansMexicoMissense MutationMutationNeeds AssessmentNutrition SurveysObesityPatternPopulationPrimary carcinoma of the liver cellsPublic HealthRecordsResearchResearch ActivityResearch InfrastructureResearch PersonnelResourcesRiskRisk FactorsRuralRural PopulationSamplingScientistSeroprevalencesSerumSurveysTP53 geneTumor TissueVariantWomanWorkadductanticancer researchbasebiobankburden of illnesscancer epidemiologycancer preventiondietaryenvironment related cancerinsightmalemenmortalityprospectivepublic health relevancerural area
项目摘要
Project Summary
Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing
hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low
prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural-
urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus,
AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates.
We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research
capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from
four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced
mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and
biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique
epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an
important resource for future environmental and cancer research, and create a strong research environment
that will foster future collaborative efforts with local, regional, and international scientists.
项目摘要
黄曲霉毒素B1(AFB 1)是食品中的一种真菌污染物,
墨西哥肝细胞癌(HCC)负担。HCC在墨西哥的流行病学是不寻常的,
乙型肝炎病毒和丙型肝炎病毒感染的患病率,男性和女性的HCC死亡率相似,农村-
城市梯度。在墨西哥,主食玉米似乎普遍受到黄曲霉毒素污染。因此,在本发明中,
AFB 1污染单独或与非病毒风险因素结合可能会导致HCC发病率上升。
我们的目标是提供关于AFB 1与墨西哥HCC相关性的初步数据,同时加强研究。
满足未来需求的能力。我们具体将(1)测量来自以下地区的955名女性和男性的循环AFB 1
四个高HCC负担地区;和(2)创建一个研究网络,以回顾性地识别黄曲霉毒素诱导的
肝脏样本中的突变,并确定前瞻性获得临床信息的可行性,
来自HCC病例的生物样本。我们将深入了解具有独特的HCC风险因素的人群,
流行病学模式,证明我们有能力进入现有的生物储存库,
为未来环境和癌症研究提供重要资源,并创造强大的研究环境
这将促进未来与当地、区域和国际科学家的合作。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Martin Lajous其他文献
Martin Lajous的其他文献
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{{ truncateString('Martin Lajous', 18)}}的其他基金
Aflatoxin exposure and hepatocellular carcinoma in Mexico
墨西哥的黄曲霉毒素暴露与肝细胞癌
- 批准号:
10238151 - 财政年份:2020
- 资助金额:
$ 8.91万 - 项目类别:
Mesoamerican Center for Population Health Research on Non-Communicable Disease
中美洲非传染性疾病人口健康研究中心
- 批准号:
9335326 - 财政年份:2016
- 资助金额:
$ 8.91万 - 项目类别:
Coordinating Unit of the Mesoamerican Center for Population Health Research on Non-Communicable Disease
中美洲非传染性疾病人口健康研究中心协调单位
- 批准号:
9193994 - 财政年份:
- 资助金额:
$ 8.91万 - 项目类别:
Coordinating Unit of the Mesoamerican Center for Population Health Research on Non-Communicable Disease
中美洲非传染性疾病人口健康研究中心协调单位
- 批准号:
9335327 - 财政年份:
- 资助金额:
$ 8.91万 - 项目类别:
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