Aflatoxin exposure and hepatocellular carcinoma in Mexico

项目摘要 黄曲霉毒素B1(AFB1)是食物中的一种真菌污染物，它可能对 墨西哥的肝细胞癌负担。在墨西哥，肝癌的流行病学是不同寻常的，因为 乙型和丙型肝炎病毒感染的流行率，男性和女性相似的肝癌死亡率，以及农村- 城市梯度。在墨西哥，主食玉米似乎普遍受到黄曲霉毒素的污染。因此， AFB1污染单独或与非病毒危险因素结合可能是肝癌发病率的驱动因素。 我们的目标是在加强研究的同时，提供有关AFB1与墨西哥肝癌相关性的初步数据 满足未来需求的能力。我们具体将(1)测量来自中国的955名女性和男性的循环AFB1 四个肝细胞癌高负担区域；以及(2)创建一个研究网络，以追溯识别黄曲霉毒素诱导的 肝脏样本中的突变，并确定前瞻性获得临床信息和 从发生的肝细胞癌病例中检出生物链霉菌。我们将深入了解患有独特疾病的人群中的肝癌危险因素 流行病学模式，展示我们访问现有生物仓库的能力，该生物仓库将成为 为未来的环境和癌症研究提供重要资源，并创造强有力的研究环境 这将促进未来与当地、地区和国际科学家的合作努力。

Project Summary Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural- urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.