Aflatoxin exposure and hepatocellular carcinoma in Mexico

墨西哥的黄曲霉毒素暴露与肝细胞癌

• 批准号: 10238151
• 负责人: Martin Lajous
• 金额: $ 12.17万
• 依托单位: MEXICO NATIONAL INSTITUTE OF PUBLIC HLTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238151
• 关键词: Address; Affect; Aflatoxin B1; Aflatoxins; Africa South of the Sahara; Albumins; Alcohols; Americas; Area; Automobile Driving; Biological Markers; Blood; Cancer Burden; Cancer Etiology; Cancer Research Network; Central America; Cessation of life; Characteristics; Clinical; Collaborations; Communities; Country; Data; Diabetes Mellitus; Environment; Environmental Health; Environmental Pollution; Epidemiology; Etiology; Evaluation; Exons; Exposure to; Face; Far East; Female; Food; Fostering; Future; Gene Mutation; Geography; Guatemala; HBV and Aflatoxin; Health Surveys; Hepatitis B Prevalence; Hepatitis B Virus; Hepatitis C virus; High Prevalence; Hispanics; Hospitals; Immigrant; Incidence; Induced Mutation; Infection; Institution; International; Liver; Low Prevalence; Maize; Measures; Metabolic syndrome; Mexican Americans; Mexico; Missense Mutation; Mutation; Needs Assessment; Nutrition Surveys; Obesity; Pattern; Population; Primary carcinoma of the liver cells; Public Health; Records; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Rural; Rural Population; Sampling; Scientist; Seroprevalences; Serum; Surveys; TP53 gene; Tumor Tissue; Variant; Woman; Work; adduct; anticancer research; base; biobank; burden of illness; cancer epidemiology; cancer prevention; dietary; environment related cancer; insight; male; men; mortality; prospective; public health relevance; rural area

PROJECT SUMMARY Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural-urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.

项目摘要 黄曲霉毒素B1（AFB 1）是食物中的一种真菌污染物，可能对食物中的 墨西哥的肝细胞癌（HCC）负担增加。墨西哥的HCC流行病学不寻常 考虑到B和C型肝炎病毒感染的低流行率， 妇女和城乡梯度。在墨西哥，玉米，一种主食， 被黄曲霉毒素污染因此，AFB 1污染单独或与非病毒风险相结合 这些因素可能导致HCC发病率上升。我们的目标是提供关于AFB 1相关性的初步数据。 在墨西哥，为HCC项目提供技术支持，同时加强研究能力以满足未来需求。我们具体将（1） 测量来自四个HCC高负担地区的955名女性和男性的循环AFB 1;和（2） 创建一个研究网络，以回顾性地识别肝脏样本中黄曲霉毒素诱导的突变， 确定从事件中前瞻性获取临床信息和生物样本的可行性 HCC病例。我们将深入了解具有独特流行病学特征的人群中的HCC风险因素， 模式，证明我们有能力进入现有的生物储存库，这将成为一个重要的 为未来的环境和癌症研究提供资源，并创造强大的研究环境 这将促进未来与当地、区域和国际科学家的合作。