Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
基本信息
- 批准号:10617472
- 负责人:
- 金额:$ 6.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcademyAcuteAddressAdolescent and Young AdultAdultAfrican AmericanAgeAmericanAnxietyAreaAsian populationBehaviorBindingBiologicalBiological AssayBiological MarkersBuffersCaliforniaCardiovascular systemCenters for Disease Control and Prevention (U.S.)ChildChild AbuseChild Abuse and NeglectChild BehaviorChild DevelopmentChild RearingChildhood InjuryChronicChronic stressClinical DataConflict (Psychology)CountyCritical IllnessDataDetectionDevelopmentDiseaseDiurnal RhythmDomestic ViolenceDrug abuseEcologyEmotionalEnvironmentEnvironmental Risk FactorEnzyme-Linked Immunosorbent AssayEpidemiologyEquipmentEthnic OriginExposure toFemaleGrowthHairHalf-LifeHealthHumanHydrocortisoneImmune systemIndividualInstitute of Medicine (U.S.)KnowledgeLeadLifeLife Cycle StagesLinkLipidsLongevityLoveMeasuresMediatingMental DepressionMental HealthMental disordersMetabolicMethodologyMethodsNational Institute of Child Health and Human DevelopmentNormal RangeOutcomeOxytocinOxytocin ReceptorParentsPediatricsPhysiologicalPreschool ChildPrevalencePrimary PreventionProcessProteinsPsychologistPsychopathologyPublic HealthRaceRecurrenceReference ValuesRegulationReportingReproducibilityResearchResearch PersonnelResearch PriorityRiskRisk BehaviorsSalivaSalivarySamplingSensitivity and SpecificitySerumSexual abuseSleepSocial supportStressSubstance abuse problemSuicideSystemTechniquesTimeTraumaVariantViolenceWaterYouthacute stressadverse childhood eventsallostatic loadbasebiological adaptation to stressdating violencedrinkingearly childhoodearly experienceearly life stressexperiencehypothalamic-pituitary-adrenal axisimprovedimproved outcomeindexingliquid chromatography mass spectrometrymalemigrationmultidisciplinarynovelnutritionpediatric traumaphysical conditioningpopulation basedpre-clinicalpsychological traumarecruitresilienceresponsesaliva sampleschool shootingsexsexual traumasocialsocioeconomicssociologiststressorsuicide ratesystematic reviewtandem mass spectrometrytrauma exposuretraumatic stress
项目摘要
Early life stress (ELS) can disrupt the development of nervous, cardiovascular, metabolic, and immune
systems, leading to poor physical and mental health throughout the lifespan. The rising prevalence of ELS in
preschool children is a major public health concern, epidemiologically linked with higher rates of youth
suicides, dating violence, drinking, and drug abuse. Individuals respond to acute stress by releasing cortisol;
thus, hair cortisol concentrations (HCC) can quantify the exposures to recurrent or chronic stress in children.
Our pilot data on HCC revealed various factors that are associated with chronic stress in preschool children.
We propose hair oxytocin concentrations (HOC) as a summative measure of supportive and/or socially
affiliative experiences. Specific aims of the proposed study are: (1) to validate novel assays for measuring
HCC and HOC in 1200 preschool children and their parents, in order to quantify their cumulative exposures to
stressful vs. supportive early experiences; and (2) to measure hair growth rates, thereby delineating the time
periods related to such exposures and their hair composition (protein, lipid, water content) to interpret and/or
adjust the HCC and HOC values obtained from the preschool children and their parents.
We will collect hair samples from children ages 1-5 years (n=1200) and at least one accompanying parent
(n=1200). From parents we will obtain their child's demographic, developmental, health and environmental
data. Hair samples will be processed using our novel extraction methods and analyzed using specific enzyme-
linked immunosorbent assays (ELISA) for HCC and HOC; these assays will be validated using tandem mass
spectrometry (LC/MS-MS). We will measure hair growth rates using the standard phototrichogram technique
and hair composition using direct spectrophotometric detection. These data will establish the reference norms
for HCC and HOC in preschool children and their hair growth rates will identify the time periods that these HCC
or HOC values represent.
We will examine the natural variations in HCC, HOC, and hair growth rates in relation to age, sex, race,
ethnicity, parental, socioeconomic, or other environmental factors. HCC and HOC values obtained from the
same hair sample will also allow us to examine oxytocin-mediated regulation of the cortisol responses to ELS.
We have a multidisciplinary team (clinician, psychologist, sociologist, biochemists, statistician), the equipment,
the experience, and pilot data to successfully complete the proposed project. Completion of this research will
provide age-specific reference norms for HCC, HOC, and hair growth rates in healthy preschool children. This
project will address fundamental gaps in our current knowledge and establish a scientific framework to
investigate long-term physical and mental health consequences of early childhood stress, following physical or
psychological trauma, traumatic/toxic stress, violence-related injury, child maltreatment, and acute or critical
illnesses – identified as a high-priority research area by NICHD.
早期生活压力 (ELS) 会扰乱神经、心血管、代谢和免疫系统的发育
系统,导致整个生命周期的身心健康状况不佳。 ELS 患病率不断上升
学龄前儿童是一个主要的公共卫生问题,从流行病学角度来看,学龄前儿童的发病率较高
自杀、约会暴力、酗酒和吸毒。个体通过释放皮质醇来应对急性压力;
因此,头发皮质醇浓度(HCC)可以量化儿童反复或慢性压力的暴露程度。
我们关于 HCC 的试点数据揭示了与学龄前儿童慢性压力相关的各种因素。
我们建议将头发催产素浓度(HOC)作为支持性和/或社交性的总结性衡量标准
附属经历。拟议研究的具体目标是:(1)验证新的测量方法
对 1200 名学龄前儿童及其父母进行 HCC 和 HOC,以量化他们的累积暴露量
早期经历的压力与支持; (2) 测量毛发生长速度,从而确定时间
与此类暴露及其头发成分(蛋白质、脂质、水含量)相关的时期来解释和/或
调整从学龄前儿童及其父母获得的 HCC 和 HOC 值。
我们将从 1-5 岁儿童 (n=1200) 和至少一名陪同家长那里收集头发样本
(n=1200)。我们将从父母那里获得他们孩子的人口、发育、健康和环境信息
数据。头发样本将使用我们的新颖提取方法进行处理,并使用特定的酶进行分析
HCC 和 HOC 的连锁免疫吸附测定 (ELISA);这些测定将使用串联质量进行验证
光谱分析(LC/MS-MS)。我们将使用标准光毛图技术测量头发生长率
使用直接分光光度法检测头发成分。这些数据将建立参考规范
学龄前儿童的 HCC 和 HOC 及其毛发生长率将确定这些 HCC 发生的时间段
或 HOC 值代表。
我们将检查 HCC、HOC 和毛发生长率与年龄、性别、种族、
种族、父母、社会经济或其他环境因素。 HCC 和 HOC 值从
相同的头发样本还可以让我们检查催产素介导的皮质醇对 ELS 反应的调节。
我们拥有多学科团队(临床医生、心理学家、社会学家、生物化学家、统计学家)、设备、
成功完成拟议项目的经验和试点数据。完成这项研究将
为健康学龄前儿童的 HCC、HOC 和毛发生长率提供特定年龄的参考标准。这
项目将解决我们当前知识的根本差距,并建立一个科学框架
调查幼儿期压力、身体或心理健康之后的长期身心健康后果
心理创伤、创伤/毒性应激、暴力相关伤害、虐待儿童以及急性或危重
疾病——被 NICHD 确定为高度优先的研究领域。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Historical roots of pain management in infants: A bibliometric analysis using reference publication year spectroscopy.
- DOI:10.1002/pne2.12035
- 发表时间:2020-06
- 期刊:
- 影响因子:0
- 作者:Anand KJS;Roue JM;Rovnaghi CR;Marx W;Bornmann L
- 通讯作者:Bornmann L
Response to Letter to the Editor.
对给编辑的信的回复。
- DOI:10.1016/j.jtho.2021.12.013
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Lin,Yannan;Fu,Mingzhou;Inoue,Kosuke;Jeon,ChristieY;Hsu,William
- 通讯作者:Hsu,William
Can Translational Social Neuroscience Research Offer Insights to Mitigate Structural Racism in the United States?
转化社会神经科学研究能否为减轻美国的结构性种族主义提供见解?
- DOI:10.1016/j.bpsc.2022.05.005
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Singh,ManpreetK;Nimarko,Akua;Bruno,Jennifer;Anand,KanwaljeetJS;Singh,SwaranP
- 通讯作者:Singh,SwaranP
Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation.
- DOI:10.3390/children4110098
- 发表时间:2017-11-15
- 期刊:
- 影响因子:0
- 作者:Elbers J;Rovnaghi CR;Golianu B;Anand KJS
- 通讯作者:Anand KJS
Longitudinal Trajectories of Hair Cortisol: Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Early Childhood.
- DOI:10.3389/fped.2021.740343
- 发表时间:2021
- 期刊:
- 影响因子:2.6
- 作者:Rovnaghi CR;Rigdon J;Roué JM;Ruiz MO;Carrion VG;Anand KJS
- 通讯作者:Anand KJS
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{{ truncateString('KANWALJEET S ANAND', 18)}}的其他基金
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
- 批准号:
10430294 - 财政年份:2021
- 资助金额:
$ 6.29万 - 项目类别:
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
- 批准号:
10172964 - 财政年份:2019
- 资助金额:
$ 6.29万 - 项目类别:
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
- 批准号:
10403638 - 财政年份:2019
- 资助金额:
$ 6.29万 - 项目类别:
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
- 批准号:
10552489 - 财政年份:2019
- 资助金额:
$ 6.29万 - 项目类别:
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
头发皮质醇和头发催产素是否代表学龄前儿童的压力和支持经历?
- 批准号:
9980931 - 财政年份:2019
- 资助金额:
$ 6.29万 - 项目类别:
PCCM Network: Remedies for Opioid Tolerance & Withdrawal
PCCM 网络:阿片类药物耐受性的补救措施
- 批准号:
7059953 - 财政年份:2005
- 资助金额:
$ 6.29万 - 项目类别:
PCCM Network: Remedies for Opioid Tolerance & Withdrawal
PCCM 网络:阿片类药物耐受性的补救措施
- 批准号:
6939079 - 财政年份:2005
- 资助金额:
$ 6.29万 - 项目类别:
PCCM Network: Remedies for Opioid Tolerance & Withdrawal
PCCM 网络:阿片类药物耐受性的补救措施
- 批准号:
7175458 - 财政年份:2005
- 资助金额:
$ 6.29万 - 项目类别:
PCCM Network: Remedies for Opioid Tolerance & Withdrawal
PCCM 网络:阿片类药物耐受性的补救措施
- 批准号:
7355595 - 财政年份:2005
- 资助金额:
$ 6.29万 - 项目类别:
NEUROLOGIC OUTCOMES AND PREEMPTIVE ANALGESIA IN NEONATES
新生儿的神经系统结局和先发性镇痛
- 批准号:
6181742 - 财政年份:1999
- 资助金额:
$ 6.29万 - 项目类别:
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