课题基金 / 基金详情

Illuminating the Druggable GPCR-ome

Illuminating the Druggable GPCR-ome
阐明可药物化的 GPCR-ome
批准号：
10612133
负责人：
Bryan L. Roth
金额：
$74.95万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-09-15 至 2023-08-31
来源：
https://reporter.nih.gov/project-details/10612133
关键词：
ArrestinsAwardCell LineChemicalsChemistryClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCommunitiesCryoelectron MicroscopyDatabasesDevelopmentDockingDrug TargetingElectron MicroscopyEngineeringEpinephrineFundingG-Protein-Coupled ReceptorsG-substrateGeneticGenetically Engineered MouseGoalsHeart RateHuman GenomeIndividualInformaticsInfrastructureInvestigationLearningLightLipidsMemoryModelingMolecular TargetMusOrphanPharmaceutical ChemistryPharmaceutical PreparationsPharmacologyPhasePhysiologicalPhysiologyPlasmidsProtein FamilyReagentReporterReporter GenesResearchResearch PersonnelResource SharingResourcesRespirationSignal TransductionSpecific qualifier valueStructureSynthesis ChemistryTechnologyTestingTissuesTransducersViralVisionYeastsbasecell typechemical geneticschemical synthesischemokinecomputer infrastructurecomputerized toolscryogenicsdata resourcedata sharingdesigner receptors exclusively activated by designer drugsdrug discoveryexperimental studygenetic approachhuman diseasein vivo Modellarge datasetsmedical schoolsnew technologynovelnovel therapeuticsoptogeneticsprogramspublic health relevancereceptorscreeningtargeted treatmenttherapeutic targettool

项目摘要

项目成果

Bryan L. Roth的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Abstract PROJECT SUMMARY G protein coupled receptors (GPCRs) represent essential molecular targets for a large number of approved as well as investigational medications. Of the 380 or so non-olfactory GPCRs in the human genome around 100 are understudied and/or orphan receptors (oGPCRs). The oGPCRs represent potential therapeutic targets although discovering drugs that modulate them is challenging. Here we will solve the structures of 15-20 oGPCRs using cryogenic electron microscopy (cryo-EM). The solved structures then will serve as templates for structure-guided drug discovery targeting these oGPCRs.
期刊论文(24)
专著(0)
科研奖励(0)
会议论文
Alternative splicing of latrophilin-3 controls synapse formation.
DOI： 10.1038/s41586-023-06913-9
发表时间： 2024-02
期刊： NATURE
影响因子： 64.8
作者： [Wang, Shuai, Deleon, Chelsea, Sun, Wenfei, Quake, Stephen R., Roth, Bryan L., Suedhof, Thomas C.]
通讯作者： Suedhof, Thomas C.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
DOI： 10.1038/nchembio.2334
发表时间： 2017-05
期刊： Nature chemical biology
影响因子： 14.8
作者： [Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL]
通讯作者： Roth BL
How Ligands Illuminate GPCR Molecular Pharmacology.
DOI： 10.1016/j.cell.2017.07.009
发表时间： 2017-07-27
期刊： Cell
影响因子： 64.5
作者： [Wacker D, Stevens RC, Roth BL]
通讯作者： Roth BL
Report and Application of a Tool Compound Data Set.
DOI： 10.1021/acs.jcim.7b00343
发表时间： 2017-11-27
期刊： Journal of chemical information and modeling
影响因子： 5.6
作者： [Butler KV, MacDonald IA, Hathaway NA, Jin J]
通讯作者： Jin J
共 9 条
    Mechanistic insights into LSD actions at 5-HT2A serotonin receptors
    STRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORS
    STRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORS
    Mechanistic insights into LSD actions at 5-HT2A serotonin receptors
    海外基金