The Columbia University Digestive and Liver Disease Research Center

哥伦比亚大学消化和肝脏疾病研究中心

• 批准号: 10612948
• 负责人: Robert F. Schwabe
• 金额: $ 121.89万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612948
• 关键词: Appointment; Automobile Driving; Basic Science; Bioinformatics; Biology; Cell Communication; Cells; Clinical; Clinical Research; Collaborations; Collection; Communities; Core Facility; Creativeness; Data; Databases; Detection; Digestive System Disorders; Direct Costs; Discipline; Disease; Education; Educational workshop; Effectiveness; Ensure; Environment; Epithelial Cells; Epithelium; Esophagus; Evolution; Functional disorder; Funding; Future; Goals; Grant; Growth; Homeostasis; Hospitals; Inflammation; Institution; Joints; Link; Liver; Liver diseases; Measures; Mentors; Metabolism; Mission; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural regeneration; Neoplasms; New York; Organ; Organoids; Pancreas; Pathway interactions; Patients; Physiology; Presbyterian Church; Prevention; Productivity; Publications; Research; Research Methodology; Research Personnel; Science; Scientist; Services; Structure; Training; Training and Education; Translations; United States National Institutes of Health; Universities; Vision; base; bioimaging; clinical application; clinical translation; clinically relevant; diversity and equity; empowerment; equity, diversity, and inclusion; forging; gastrointestinal; improved; innovation; inter-institutional; member; mortality; multidisciplinary; next generation; novel therapeutic intervention; patient population; programs; single cell analysis; success; symposium; therapeutic target

SUMMARY Since its formal inception in 2019, the Columbia University Digestive and Liver Disease Research Center (CU- DLDRC) has brought together an interdisciplinary group of highly accomplished basic, translational and clinical researchers with complementary backgrounds from different departments and campuses and the New York Presbyterian Hospital. The CU-DLDRC reflects vibrant growth in digestive disease science over the last two decades, paired with exceptional institutional support and a dynamic scientific environment at Columbia University. The CU-DLDRC’s vision is to contribute to improved prevention, detection and therapy of digestive diseases through the application of creative concepts, cutting-edge research methods, innovation and multi- disciplinary team science, with a strong emphasis on clinical relevance and translation. The CU-DLDRC includes 49 digestive-focused members (30 full, 19 associate) with NIH funding of $20.8M direct costs (35.6% from NIDDK). The central theme “Epithelial cells and their interactions in digestive homeostasis and disease”, reflects the passion and expertise of its members and its key role in digestive diseases. The broad coverage of digestive organs under this theme is predicated upon the conceptual framework that many disease-driving pathways, cell- cell interactions and therapeutic targets are shared across digestive organs. Guided by these principles, digestive disease research at Columbia has witnessed significant growth and impact, fruitful collaborations and joint publications and grants to a degree that would not have been achieved by studies in single digestive organs. The Administrative Core ensures success and effectiveness of the CU-DLDRC through management of its research base, operational oversight, scientific vision, innovation, and structures and activities that stimulate translational digestive science with maximum member benefits (Aim 1). The four biomedical cores offer a suite of closely linked state-of-the-art core facilities that span from clinical biospecimens and databases to cutting- edge bioinformatics, organoid platforms and advanced bioimaging, empowering members to investigate epithelial cells and their interactions; these powerful research methods will be linked the breadth of clinical expertise and biospecimens via organ-focused clinical-basic teams (Aim 2). The Pilot and Feasibility program, that to date has funded seven investigators with an exceptional rate of return, will promote impactful basic and clinical projects, thereby promoting new investigators, innovation and the integration of excellence from other fields (Aim 3). The Enrichment Program will stimulate intellectual exchange within our center and with the national digestive community through seminars, an annual retreat, and basic-clinical symposia; support new investigators and training through a formal mentoring program and workshops; and promote Diversity, Equity and Inclusion (DEI) in all components and activities of the CU-DLDRC through a DEI delegate (Aim 4). Through these Aims, the CU-DLDRC will make impactful contributions to digestive disease research and serve our patients.

总结 自2019年正式成立以来，哥伦比亚大学消化和肝病研究中心（CU- DLDRC）汇集了一个跨学科的小组，高度完成的基础，翻译和临床 来自不同部门和校园以及纽约的互补背景的研究人员 长老会医院CU-DLDRC反映了过去两年消化系统疾病科学的蓬勃发展 几十年来，加上特殊的机构支持和哥伦比亚充满活力的科学环境， 大学CU-DLDRC的愿景是为改善消化道疾病的预防，检测和治疗做出贡献。 疾病通过应用创造性的概念，前沿的研究方法，创新和多， 学科团队科学，重点是临床相关性和翻译。CU-DLDRC包括 49个以消化为重点的成员（30个正式成员，19个副成员），NIH资助2080万美元的直接费用（35.6%来自 NIDDK）。中心主题“上皮细胞及其在消化系统稳态和疾病中的相互作用”，反映了 其成员的热情和专业知识及其在消化系统疾病中的关键作用。消化道的广泛覆盖 这一主题下的器官是基于概念框架，许多疾病驱动途径，细胞， 细胞相互作用和治疗靶点在消化器官中是共享的。在这些原则的指导下， 哥伦比亚的消化系统疾病研究见证了显着的增长和影响，富有成效的合作， 联合出版物和赠款的程度，将不会通过在单一消化器官的研究实现。 行政核心确保CU-DLDRC的成功和有效性， 研究基础、业务监督、科学愿景、创新，以及促进发展的结构和活动 翻译消化科学与最大的成员利益（目标1）。四个生物医学核心提供了一套 紧密相连的最先进的核心设施，从临床生物标本和数据库到切割- 边缘生物信息学、类器官平台和先进的生物成像，使会员能够进行调查 上皮细胞及其相互作用;这些强大的研究方法将与临床研究的广度联系起来。 通过以器官为中心的临床基础团队提供专业知识和生物标本（目标2）。试点和可行性计划， 迄今为止，该基金已资助了7名调查人员，回报率非常高，将促进有影响力的基本和 临床项目，从而促进新的研究者，创新和整合卓越的其他 领域（目标3）。丰富计划将促进我们中心内的知识交流，并与国家 通过研讨会，年度务虚会和基础临床研讨会消化社区;支持新的研究人员 通过正式的指导计划和研讨会进行培训;并促进多样性，公平和包容性 (DEI)通过环境倡议的一名代表，参与CU-DLDRC的所有组成部分和活动（目标4）。通过这些目标， CU-DLDRC将为消化系统疾病研究做出有影响力的贡献，并为我们的患者服务。

项目成果

Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015.

• DOI: 10.1136/gutjnl-2021-324209
• 发表时间: 2022-06
• 期刊: GUT
• 影响因子: 24.5
• 作者: Bergman, David;King, James;Lebwohl, Benjamin;Clements, Mark S.;Roelstraete, Bjorn;Kaplan, Gilaad G.;Green, Peter H. R.;Murray, Joseph A.;Ludvigsson, Jonas F.
• 通讯作者: Ludvigsson, Jonas F.

Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach.

• DOI: 10.1016/j.jcmgh.2022.09.008
• 发表时间: 2023
• 期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 7.2
• 作者: Kim, Kwang H.;Park, Jihwan;Cho, Yejin;Cho, Soo Young;Lee, Buhyun;Jeong, Haengdueng;Lee, Yura;Yi, Ja-Woon;Oh, Yeseul;Lee, Jin-Jae;Wang, Timothy C.;Lim, Kyung-Min;Nam, Ki Taek
• 通讯作者: Nam, Ki Taek

Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.

• DOI: 10.1007/s00259-021-05582-y
• 发表时间: 2022-05
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Fang, Hsin-Yu;Stangl, Stefan;Marcazzan, Sabrina;Carvalho, Marcos J. Braz;Baumeister, Theresa;Anand, Akanksha;Strangmann, Julia;Huspenina, Julia Slotta;Wang, Timothy C.;Schmid, Roland M.;Feith, Marcus;Friess, Helmut;Ntziachristos, Vasilis;Multhoff, Gabriele;Gorpas, Dimitris;Quante, Michael
• 通讯作者: Quante, Michael

Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened.

• DOI: 10.1001/jamanetworkopen.2023.43392
• 发表时间: 2023-11-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Aziz, Zainab;Wagner, Sophie;Agyekum, Alice;Pumpalova, Yoanna S.;Prest, Matthew;Lim, Francesca;Rustgi, Sheila;Kastrinos, Fay;Grady, William M.;Hur, Chin
• 通讯作者: Hur, Chin

Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus.

• DOI: 10.1136/gutjnl-2021-326645
• 发表时间: 2022-11
• 期刊: GUT
• 影响因子: 24.5
• 作者: Schiepatti, Annalisa;Sanders, David S.;Baiardi, Paola;Caio, Giacomo;Ciacci, Carolina;Kaukinen, Katri;Lebwohl, Benjamin;Leffler, Daniel;Malamut, Georgia;Murray, Joseph A.;Rostami, Kamran;Rubio-Tapia, Alberto;Volta, Umberto;Biagi, Federico
• 通讯作者: Biagi, Federico