The Columbia University Digestive and Liver Disease Research Center
哥伦比亚大学消化和肝脏疾病研究中心
基本信息
- 批准号:10612948
- 负责人:
- 金额:$ 121.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-30 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AppointmentAutomobile DrivingBasic ScienceBioinformaticsBiologyCell CommunicationCellsClinicalClinical ResearchCollaborationsCollectionCommunitiesCore FacilityCreativenessDataDatabasesDetectionDigestive System DisordersDirect CostsDisciplineDiseaseEducationEducational workshopEffectivenessEnsureEnvironmentEpithelial CellsEpitheliumEsophagusEvolutionFunctional disorderFundingFutureGoalsGrantGrowthHomeostasisHospitalsInflammationInstitutionJointsLinkLiverLiver diseasesMeasuresMentorsMetabolismMissionMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNatural regenerationNeoplasmsNew YorkOrganOrganoidsPancreasPathway interactionsPatientsPhysiologyPresbyterian ChurchPreventionProductivityPublicationsResearchResearch MethodologyResearch PersonnelScienceScientistServicesStructureTrainingTraining and EducationTranslationsUnited States National Institutes of HealthUniversitiesVisionbasebioimagingclinical applicationclinical translationclinically relevantdiversity and equityempowermentequity, diversity, and inclusionforginggastrointestinalimprovedinnovationinter-institutionalmembermortalitymultidisciplinarynext generationnovel therapeutic interventionpatient populationprogramssingle cell analysissuccesssymposiumtherapeutic target
项目摘要
SUMMARY
Since its formal inception in 2019, the Columbia University Digestive and Liver Disease Research Center (CU-
DLDRC) has brought together an interdisciplinary group of highly accomplished basic, translational and clinical
researchers with complementary backgrounds from different departments and campuses and the New York
Presbyterian Hospital. The CU-DLDRC reflects vibrant growth in digestive disease science over the last two
decades, paired with exceptional institutional support and a dynamic scientific environment at Columbia
University. The CU-DLDRC’s vision is to contribute to improved prevention, detection and therapy of digestive
diseases through the application of creative concepts, cutting-edge research methods, innovation and multi-
disciplinary team science, with a strong emphasis on clinical relevance and translation. The CU-DLDRC includes
49 digestive-focused members (30 full, 19 associate) with NIH funding of $20.8M direct costs (35.6% from
NIDDK). The central theme “Epithelial cells and their interactions in digestive homeostasis and disease”, reflects
the passion and expertise of its members and its key role in digestive diseases. The broad coverage of digestive
organs under this theme is predicated upon the conceptual framework that many disease-driving pathways, cell-
cell interactions and therapeutic targets are shared across digestive organs. Guided by these principles,
digestive disease research at Columbia has witnessed significant growth and impact, fruitful collaborations and
joint publications and grants to a degree that would not have been achieved by studies in single digestive organs.
The Administrative Core ensures success and effectiveness of the CU-DLDRC through management of its
research base, operational oversight, scientific vision, innovation, and structures and activities that stimulate
translational digestive science with maximum member benefits (Aim 1). The four biomedical cores offer a suite
of closely linked state-of-the-art core facilities that span from clinical biospecimens and databases to cutting-
edge bioinformatics, organoid platforms and advanced bioimaging, empowering members to investigate
epithelial cells and their interactions; these powerful research methods will be linked the breadth of clinical
expertise and biospecimens via organ-focused clinical-basic teams (Aim 2). The Pilot and Feasibility program,
that to date has funded seven investigators with an exceptional rate of return, will promote impactful basic and
clinical projects, thereby promoting new investigators, innovation and the integration of excellence from other
fields (Aim 3). The Enrichment Program will stimulate intellectual exchange within our center and with the national
digestive community through seminars, an annual retreat, and basic-clinical symposia; support new investigators
and training through a formal mentoring program and workshops; and promote Diversity, Equity and Inclusion
(DEI) in all components and activities of the CU-DLDRC through a DEI delegate (Aim 4). Through these Aims,
the CU-DLDRC will make impactful contributions to digestive disease research and serve our patients.
总结
项目成果
期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015.
- DOI:10.1136/gutjnl-2021-324209
- 发表时间:2022-06
- 期刊:
- 影响因子:24.5
- 作者:Bergman, David;King, James;Lebwohl, Benjamin;Clements, Mark S.;Roelstraete, Bjorn;Kaplan, Gilaad G.;Green, Peter H. R.;Murray, Joseph A.;Ludvigsson, Jonas F.
- 通讯作者:Ludvigsson, Jonas F.
Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach.
- DOI:10.1016/j.jcmgh.2022.09.008
- 发表时间:2023
- 期刊:
- 影响因子:7.2
- 作者:Kim, Kwang H.;Park, Jihwan;Cho, Yejin;Cho, Soo Young;Lee, Buhyun;Jeong, Haengdueng;Lee, Yura;Yi, Ja-Woon;Oh, Yeseul;Lee, Jin-Jae;Wang, Timothy C.;Lim, Kyung-Min;Nam, Ki Taek
- 通讯作者:Nam, Ki Taek
Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.
- DOI:10.1007/s00259-021-05582-y
- 发表时间:2022-05
- 期刊:
- 影响因子:9.1
- 作者:Fang, Hsin-Yu;Stangl, Stefan;Marcazzan, Sabrina;Carvalho, Marcos J. Braz;Baumeister, Theresa;Anand, Akanksha;Strangmann, Julia;Huspenina, Julia Slotta;Wang, Timothy C.;Schmid, Roland M.;Feith, Marcus;Friess, Helmut;Ntziachristos, Vasilis;Multhoff, Gabriele;Gorpas, Dimitris;Quante, Michael
- 通讯作者:Quante, Michael
Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus.
- DOI:10.1136/gutjnl-2021-326645
- 发表时间:2022-11
- 期刊:
- 影响因子:24.5
- 作者:Schiepatti, Annalisa;Sanders, David S.;Baiardi, Paola;Caio, Giacomo;Ciacci, Carolina;Kaukinen, Katri;Lebwohl, Benjamin;Leffler, Daniel;Malamut, Georgia;Murray, Joseph A.;Rostami, Kamran;Rubio-Tapia, Alberto;Volta, Umberto;Biagi, Federico
- 通讯作者:Biagi, Federico
Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened.
- DOI:10.1001/jamanetworkopen.2023.43392
- 发表时间:2023-11-01
- 期刊:
- 影响因子:13.8
- 作者:Aziz, Zainab;Wagner, Sophie;Agyekum, Alice;Pumpalova, Yoanna S.;Prest, Matthew;Lim, Francesca;Rustgi, Sheila;Kastrinos, Fay;Grady, William M.;Hur, Chin
- 通讯作者:Hur, Chin
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Robert F. Schwabe其他文献
CD40 activates NFKB and JNK and enhances IL-8 secretion on human hepatic myofibroblasts
- DOI:
10.1016/s0016-5085(00)86204-6 - 发表时间:
2000-04-01 - 期刊:
- 影响因子:
- 作者:
Robert F. Schwabe;Bernd Schnabl;David A. Brenner - 通讯作者:
David A. Brenner
OS-041-YI - X-box binding protein 1 (XBP1) in hepatic stellate cells (HSC) mitigates liver fibrosis
- DOI:
10.1016/s0168-8278(23)00497-x - 发表时间:
2023-06-01 - 期刊:
- 影响因子:
- 作者:
Hanghang Wu;Hui Ye;Juan Francisco Vilchez-Gómez;Marcos Fernandez Fondevila;Aveline Filliol;Robert F. Schwabe;Javier Vaquero;Rafael Bañares;Ruben Nogueiras;Eduardo Martínez-Naves;Scott Friedman;Yulia Nevzorova;Francisco Javier Cubero - 通讯作者:
Francisco Javier Cubero
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
肝星状细胞通过 R-spondin 3 控制肝脏分区、大小和功能
- DOI:
10.1038/s41586-025-08677-w - 发表时间:
2025-03-12 - 期刊:
- 影响因子:48.500
- 作者:
Atsushi Sugimoto;Yoshinobu Saito;Guanxiong Wang;Qiuyan Sun;Chuan Yin;Ki Hong Lee;Yana Geng;Presha Rajbhandari;Celine Hernandez;Marcella Steffani;Jingran Qie;Thomas Savage;Dhruv M. Goyal;Kevin C. Ray;Taruna V. Neelakantan;Deqi Yin;Johannes Melms;Brandon M. Lehrich;Tyler M. Yasaka;Silvia Liu;Michael Oertel;Tian Lan;Adrien Guillot;Moritz Peiseler;Aveline Filliol;Hiroaki Kanzaki;Naoto Fujiwara;Samhita Ravi;Benjamin Izar;Mario Brosch;Jochen Hampe;Helen Remotti;Josepmaria Argemi;Zhaoli Sun;Timothy J. Kendall;Yujin Hoshida;Frank Tacke;Jonathan A. Fallowfield;Storm K. Blockley-Powell;Rebecca A. Haeusler;Jonathan B. Steinman;Utpal B. Pajvani;Satdarshan P. Monga;Ramon Bataller;Mojgan Masoodi;Nicholas Arpaia;Youngmin A. Lee;Brent R. Stockwell;Hellmut G. Augustin;Robert F. Schwabe - 通讯作者:
Robert F. Schwabe
Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease
肝星状细胞:在健康和疾病中平衡稳态、肝保护和纤维化
- DOI:
10.1038/s41575-025-01068-6 - 发表时间:
2025-05-22 - 期刊:
- 影响因子:51.000
- 作者:
Robert F. Schwabe;David A. Brenner - 通讯作者:
David A. Brenner
Modulation of soluble CD40 ligand bioactivity with anti-CD40 antibodies.
用抗 CD40 抗体调节可溶性 CD40 配体生物活性。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
Robert F. Schwabe;S. Hess;Judith P. Johnson;Hartmut Engelmann - 通讯作者:
Hartmut Engelmann
Robert F. Schwabe的其他文献
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{{ truncateString('Robert F. Schwabe', 18)}}的其他基金
The Columbia University Digestive and Liver Disease Research Center
哥伦比亚大学消化和肝脏疾病研究中心
- 批准号:
10443133 - 财政年份:2022
- 资助金额:
$ 121.89万 - 项目类别:
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
肝星状细胞亚群在 NASH-HCC 中的促肿瘤和抑肿瘤作用
- 批准号:
10278434 - 财政年份:2021
- 资助金额:
$ 121.89万 - 项目类别:
Protective and fibrosis-independent functions of hepatic stellate cells
肝星状细胞的保护性和纤维化独立功能
- 批准号:
10597076 - 财政年份:2021
- 资助金额:
$ 121.89万 - 项目类别:
Protective and fibrosis-independent functions of hepatic stellate cells
肝星状细胞的保护性和纤维化独立功能
- 批准号:
10378664 - 财政年份:2021
- 资助金额:
$ 121.89万 - 项目类别:
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
肝星状细胞亚群在 NASH-HCC 中的促肿瘤和抑肿瘤作用
- 批准号:
10454375 - 财政年份:2021
- 资助金额:
$ 121.89万 - 项目类别:
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
肝星状细胞亚群在 NASH-HCC 中的促肿瘤和抑肿瘤作用
- 批准号:
10654714 - 财政年份:2021
- 资助金额:
$ 121.89万 - 项目类别:
DAMPs and Their Receptors Link Hepatocyte Death to HSC Activation and Liver Fibrosis
DAMP 及其受体将肝细胞死亡与 HSC 激活和肝纤维化联系起来
- 批准号:
10224799 - 财政年份:2019
- 资助金额:
$ 121.89万 - 项目类别:
DAMPs and Their Receptors Link Hepatocyte Death to HSC Activation and Liver Fibrosis
DAMP 及其受体将肝细胞死亡与 HSC 激活和肝纤维化联系起来
- 批准号:
9917105 - 财政年份:2019
- 资助金额:
$ 121.89万 - 项目类别:
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