Project 2 - Deciphering the Molecular Drivers of Common Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches

项目 2 - 使用综合基因组、细胞和表型组方法破译人类不孕症常见形式的分子驱动因素

基本信息

  • 批准号:
    10613360
  • 负责人:
  • 金额:
    $ 24.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-10 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT ABSTRACT Infertility is a common condition that affects over one-tenth of couples attempting to conceive, and the costs of managing infertility exceed 18 billion US dollars worldwide. There are significant gaps in our knowledge of the underlying mechanisms and risk factors for infertility, and these gaps impede the development of targeted treatments that address the root causes of infertility. Project 2 will fill these gaps by conducting human genetic studies of unprecedented scale to study infertility, and related reproductive traits. Through collaborations with large biobanks worldwide, we will access data from over 18 million individuals to identify genetic variants associated with risk for female and male infertility as well as those associated with a number of fertility-related traits, including sex-hormone concentrations, pubertal onset, and pituitary gland and olfactory bulb size (Aim 1). We will then use state-of-the-art computational approaches to pinpoint the specific variants, genes, pathways, and cell types that influence these conditions and traits (Aim 2). These approaches include fine-mapping, pathway analyses, and intersection of genetic association data across studies, and they will be fueled by data from Project 2, Aim 1, as well as data on genetic variants associated with rare infertility conditions identified in Project 1, data on gene expression generated by the Core, as well as extensive publicly available data on genetic linkage patterns, gene expression, protein-protein interactions, and other experimental findings. We will then integrate all these findings to understand how infertility and the reproductive traits studied in Aim 1 relate to each other, with the rare infertility conditions in Project 1, and with general reproductive and non-reproductive health (Aim 3). Phenome-wide association studies will analyze a large number of phenotypes to reveal novel phenotypic associations for the genetic variants studied, investigations of pleiotropy will determine the extent to which the genetic causes of these conditions and traits overlap, and the technique of Mendelian randomization will be used to infer causal relationships. By leveraging the power of large-scale human genetics, this project will lead to a comprehensive understanding of the biology of fertility and infertility, identify targets for fertility treatments, and reveal the pathways by which reproductive health influences overall health.
项目摘要 不孕症是一种常见的疾病,影响了十分之一以上试图怀孕的夫妇, 全球治疗不孕症的费用超过180亿美元。在我们的知识中有很大的差距, 不孕症的潜在机制和风险因素,这些差距阻碍了有针对性的发展。 治疗不孕症的根本原因。项目2将填补这些空白, 研究规模空前的研究不孕症和相关的生殖特征。通过与 全球大型生物银行,我们将访问超过1800万人的数据,以确定遗传变异 与女性和男性不育的风险相关,以及与一些生育相关的风险相关, 性状,包括性激素浓度,青春期开始,脑垂体和嗅球的大小(目标1)。 然后,我们将使用最先进的计算方法来确定特定的变异,基因,途径, 以及影响这些条件和性状的细胞类型(目的2)。这些方法包括精细映射, 途径分析,以及跨研究的遗传关联数据的交叉,它们将由数据推动 来自项目2,目标1,以及与罕见不育症相关的遗传变异数据, 项目1,核心产生的基因表达数据,以及广泛的公开可用的基因表达数据。 连锁模式,基因表达,蛋白质-蛋白质相互作用和其他实验发现。然后我们将 整合所有这些发现,以了解目标1中研究的不育和生殖特征如何相互关联, 其他,项目1中罕见的不孕症,一般生殖和非生殖健康 (Aim(3)第三章。全表型关联研究将分析大量表型,以揭示新的表型。 研究的遗传变异的关联,多效性的调查将确定在多大程度上, 这些条件和特征的遗传原因重叠,并将使用孟德尔随机化技术 来推断因果关系通过利用大规模人类遗传学的力量,这个项目将导致一个 全面了解生育和不育的生物学,确定生育治疗的目标, 揭示生殖健康影响整体健康的途径。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Cecilia M. Lindgren其他文献

Genetic analysis of over one million people identifies 535 novel loci for blood pressure
对超过 100 万人的基因分析确定了 535 个新的血压基因座
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    E. Evangelou;H. Warren;D. Mosén;Borbála Mifsud;R. Pazoki;He Gao;Georgios Ntritsos;N. Dimou;Claudia P. Cabrera;I. Karaman;F. L. Ng;M. Evangelou;K. Witkowska;E. Tzanis;J. Hellwege;Ayush Giri;D. V. Velez Edwards;Yan V. Sun;Kelly Cho;J. Gaziano;P. W. Wilson;P. Tsao;C. Kovesdy;T. Esko;R. Mägi;L. Milani;P. Almgren;Thibaud S. Boutin;S. Debette;Jun Ding;Franco Giulianini;Elizabeth G. Holliday;A. Jackson;R. Li;Wei;J. Luan;M. Mangino;C. Oldmeadow;B. Prins;Yong Qian;M. Sargurupremraj;Nabi Shah;P. Surendran;S. Thériault;N. Verweij;Sara M. Willems;Jinghua Zhao;P. Amouyel;J. Connell;R. de Mutsert;Alex S. F. Doney;M. Farrall;C. Menni;A. D. Morris;R. Noordam;G. Paré;Neil R. Poulter;Denis C. Shields;A. Stanton;S. Thom;G. Abecasis;N. Amin;D. Arking;Kristin L. Ayers;C. Barbieri;C. Batini;J. Bis;T. Blake;M. Bochud;M. Boehnke;E. Boerwinkle;D. Boomsma;Erwin P. Bottinger;P. Braund;M. Brumat;A. Campbell;H. Campbell;A. Chakravarti;J. Chambers;G. Chauhan;M. Ciullo;M. Cocca;F. Collins;Heather J. Cordell;G. Davies;M. D. de Borst;E. D. de Geus;I. Deary;J. Deelen;Fabiola M. Del Greco;C. Demirkale;M. Dörr;George B. Ehret;R. Elosúa;Stefan Enroth;A. Erzurumluoglu;T. Ferreira;Mattias Frånberg;Oscar H. Franco;I. Gandin;P. Gasparini;V. Giedraitis;C. Gieger;G. Girotto;A. Goel;A. Gow;V. Gudnason;Xiuqing Guo;U. Gyllensten;A. Hamsten;T. Harris;Sarah E. Harris;C. Hartman;A. Havulinna;Andrew A. Hicks;E. Hofer;A. Hofman;J. Hottenga;J. Huffman;Shih;E. Ingelsson;A. James;R. Jansen;M. Jarvelin;R. Joehanes;Å. Johansson;Andrew D. Johnson;P. Joshi;P. Jousilahti;J. Jukema;A. Jula;M. Kähönen;S. Kathiresan;B. Keavney;K. Khaw;P. Knekt;J. Knight;I. Kolčić;J. Kooner;S. Koskinen;K. Kristiansson;Z. Kutalik;M. Laan;M. Larson;L. Launer;B. Lehne;T. Lehtimäki;D. Levy;D. Liewald;L. Lin;L. Lind;Cecilia M. Lindgren;Yongmei Liu;Ruth J. F. Loos;Lorna M. Lopez;Lingchan Lu;L. Lyytikäinen;A. Mahajan;Chrysovalanto Mamasoula;J. Marrugat;J. Marten;Y. Milaneschi;A. Morgan;Andrew P. Morris;A. Morrison;Peter J. Munson;Michael A. Nalls;P. Nandakumar;C. Nelson;C. Newton‐Cheh;T. Niiranen;I. Nolte;T. Nutile;A. Oldehinkel;B. Oostra;Paul F. O’Reilly;E. Org;S. Padmanabhan;W. Palmas;A. Palotie;A. Pattie;B. Penninx;M. Perola;A. Peters;O. Polašek;P. Pramstaller;N. Quang Tri;Olli T. Raitakari;M. Ren;R. Rettig;K. Rice;P. Ridker;Janina S Reid;H. Riese;S. Ripatti;A. Robino;L. Rose;Jerome I. Rotter;I. Rudan;D. Ruggiero;Y. Saba;C. Sala;V. Salomaa;Nilesh J. Samani;Antti;R. Schmidt;H. Schmidt;N. Shrine;D. Siscovick;Albert V. Smith;Harold Schneider;S. Sõber;R. Sorice;J. Starr;D. Stott;David P. Strachan;R. Strawbridge;J. Sundström;M. Swertz;Kent D. Taylor;A. Teumer;MartinD. Tobin;D. Toniolo;M. Traglia;S. Trompet;J. Tuomilehto;C. Tzourio;A. Uitterlinden;Ahmad Vaez;Peter J. van der Most;Cornelia M. van Duijn;A. Vergnaud;G. Verwoert;V. Vitart;U. Völker;P. Vollenweider;D. Vuckovic;H. Watkins;Sarah H Wild;G. Willemsen;James F. Wilson;Alan F. Wright;J. Yao;T. Zemunik;Weihua Zhang;J. Attia;A. Butterworth;D. Chasman;D. Conen;F. Cucca;J. Danesh;C. Hayward;J. Howson;M. Laakso;E. Lakatta;C. Langenberg;O. Melander;D. Mook;P. Munroe;Colin N. Palmer;L. Risch;Robert A. Scott;Rodney J. Scott;P. Sever;T. Spector;P. van der Harst;N. Wareham;E. Zeggini;Morris J. Brown;A. Metspalu;Adriana M. Hung;Christopher J. O’Donnell;Todd L. Edwards;B. Psaty;I. Tzoulaki;Michael R Barnes;L. Wain;P. Elliott;M. Caulfield
  • 通讯作者:
    M. Caulfield
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
2 型糖尿病病理生理学中异质性的遗传驱动因素
  • DOI:
    10.1038/s41586-024-07019-6
  • 发表时间:
    2024-02-19
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Ken Suzuki;Konstantinos Hatzikotoulas;Lorraine Southam;Henry J. Taylor;Xianyong Yin;Kim M. Lorenz;Ravi Mandla;Alicia Huerta-Chagoya;Giorgio E. M. Melloni;Stavroula Kanoni;Nigel W. Rayner;Ozvan Bocher;Ana Luiza Arruda;Kyuto Sonehara;Shinichi Namba;Simon S. K. Lee;Michael H. Preuss;Lauren E. Petty;Philip Schroeder;Brett Vanderwerff;Mart Kals;Fiona Bragg;Kuang Lin;Xiuqing Guo;Weihua Zhang;Jie Yao;Young Jin Kim;Mariaelisa Graff;Fumihiko Takeuchi;Jana Nano;Amel Lamri;Masahiro Nakatochi;Sanghoon Moon;Robert A. Scott;James P. Cook;Jung-Jin Lee;Ian Pan;Daniel Taliun;Esteban J. Parra;Jin-Fang Chai;Lawrence F. Bielak;Yasuharu Tabara;Yang Hai;Gudmar Thorleifsson;Niels Grarup;Tamar Sofer;Matthias Wuttke;Chloé Sarnowski;Christian Gieger;Darryl Nousome;Stella Trompet;Soo-Heon Kwak;Jirong Long;Meng Sun;Lin Tong;Wei-Min Chen;Suraj S. Nongmaithem;Raymond Noordam;Victor J. Y. Lim;Claudia H. T. Tam;Yoonjung Yoonie Joo;Chien-Hsiun Chen;Laura M. Raffield;Bram Peter Prins;Aude Nicolas;Lisa R. Yanek;Guanjie Chen;Jennifer A. Brody;Edmond Kabagambe;Ping An;Anny H. Xiang;Hyeok Sun Choi;Brian E. Cade;Jingyi Tan;K. Alaine Broadaway;Alice Williamson;Zoha Kamali;Jinrui Cui;Manonanthini Thangam;Linda S. Adair;Adebowale Adeyemo;Carlos A. Aguilar-Salinas;Tarunveer S. Ahluwalia;Sonia S. Anand;Alain Bertoni;Jette Bork-Jensen;Ivan Brandslund;Thomas A. Buchanan;Charles F. Burant;Adam S. Butterworth;Mickaël Canouil;Juliana C. N. Chan;Li-Ching Chang;Miao-Li Chee;Ji Chen;Shyh-Huei Chen;Yuan-Tsong Chen;Zhengming Chen;Lee-Ming Chuang;Mary Cushman;John Danesh;Swapan K. Das;H. Janaka de Silva;George Dedoussis;Latchezar Dimitrov;Ayo P. Doumatey;Shufa Du;Qing Duan;Kai-Uwe Eckardt;Leslie S. Emery;Daniel S. Evans;Michele K. Evans;Krista Fischer;James S. Floyd;Ian Ford;Oscar H. Franco;Timothy M. Frayling;Barry I. Freedman;Pauline Genter;Hertzel C. Gerstein;Vilmantas Giedraitis;Clicerio González-Villalpando;Maria Elena González-Villalpando;Penny Gordon-Larsen;Myron Gross;Lindsay A. Guare;Sophie Hackinger;Liisa Hakaste;Sohee Han;Andrew T. Hattersley;Christian Herder;Momoko Horikoshi;Annie-Green Howard;Willa Hsueh;Mengna Huang;Wei Huang;Yi-Jen Hung;Mi Yeong Hwang;Chii-Min Hwu;Sahoko Ichihara;Mohammad Arfan Ikram;Martin Ingelsson;Md. Tariqul Islam;Masato Isono;Hye-Mi Jang;Farzana Jasmine;Guozhi Jiang;Jost B. Jonas;Torben Jørgensen;Frederick K. Kamanu;Fouad R. Kandeel;Anuradhani Kasturiratne;Tomohiro Katsuya;Varinderpal Kaur;Takahisa Kawaguchi;Jacob M. Keaton;Abel N. Kho;Chiea-Chuen Khor;Muhammad G. Kibriya;Duk-Hwan Kim;Florian Kronenberg;Johanna Kuusisto;Kristi Läll;Leslie A. Lange;Kyung Min Lee;Myung-Shik Lee;Nanette R. Lee;Aaron Leong;Liming Li;Yun Li;Ruifang Li-Gao;Symen Ligthart;Cecilia M. Lindgren;Allan Linneberg;Ching-Ti Liu;Jianjun Liu;Adam E. Locke;Tin Louie;Jian’an Luan;Andrea O. Luk;Xi Luo;Jun Lv;Julie A. Lynch;Valeriya Lyssenko;Shiro Maeda;Vasiliki Mamakou;Sohail Rafik Mansuri;Koichi Matsuda;Thomas Meitinger;Olle Melander;Andres Metspalu;Huan Mo;Andrew D. Morris;Filipe A. Moura;Jerry L. Nadler;Michael A. Nalls;Uma Nayak;Ioanna Ntalla;Yukinori Okada;Lorena Orozco;Sanjay R. Patel;Snehal Patil;Pei Pei;Mark A. Pereira;Annette Peters;Fraser J. Pirie;Hannah G. Polikowsky;Bianca Porneala;Gauri Prasad;Laura J. Rasmussen-Torvik;Alexander P. Reiner;Michael Roden;Rebecca Rohde;Katheryn Roll;Charumathi Sabanayagam;Kevin Sandow;Alagu Sankareswaran;Naveed Sattar;Sebastian Schönherr;Mohammad Shahriar;Botong Shen;Jinxiu Shi;Dong Mun Shin;Nobuhiro Shojima;Jennifer A. Smith;Wing Yee So;Alena Stančáková;Valgerdur Steinthorsdottir;Adrienne M. Stilp;Konstantin Strauch;Kent D. Taylor;Barbara Thorand;Unnur Thorsteinsdottir;Brian Tomlinson;Tam C. Tran;Fuu-Jen Tsai;Jaakko Tuomilehto;Teresa Tusie-Luna;Miriam S. Udler;Adan Valladares-Salgado;Rob M. van Dam;Jan B. van Klinken;Rohit Varma;Niels Wacher-Rodarte;Eleanor Wheeler;Ananda R. Wickremasinghe;Ko Willems van Dijk;Daniel R. Witte;Chittaranjan S. Yajnik;Ken Yamamoto;Kenichi Yamamoto;Kyungheon Yoon;Canqing Yu;Jian-Min Yuan;Salim Yusuf;Matthew Zawistowski;Liang Zhang;Wei Zheng;Leslie J. Raffel;Michiya Igase;Eli Ipp;Susan Redline;Yoon Shin Cho;Lars Lind;Michael A. Province;Myriam Fornage;Craig L. Hanis;Erik Ingelsson;Alan B. Zonderman;Bruce M. Psaty;Ya-Xing Wang;Charles N. Rotimi;Diane M. Becker;Fumihiko Matsuda;Yongmei Liu;Mitsuhiro Yokota;Sharon L. R. Kardia;Patricia A. Peyser;James S. Pankow;James C. Engert;Amélie Bonnefond;Philippe Froguel;James G. Wilson;Wayne H. H. Sheu;Jer-Yuarn Wu;M. Geoffrey Hayes;Ronald C. W. Ma;Tien-Yin Wong;Dennis O. Mook-Kanamori;Tiinamaija Tuomi;Giriraj R. Chandak;Francis S. Collins;Dwaipayan Bharadwaj;Guillaume Paré;Michèle M. Sale;Habibul Ahsan;Ayesha A. Motala;Xiao-Ou Shu;Kyong-Soo Park;J. Wouter Jukema;Miguel Cruz;Yii-Der Ida Chen;Stephen S. Rich;Roberta McKean-Cowdin;Harald Grallert;Ching-Yu Cheng;Mohsen Ghanbari;E-Shyong Tai;Josee Dupuis;Norihiro Kato;Markku Laakso;Anna Köttgen;Woon-Puay Koh;Donald W. Bowden;Colin N. A. Palmer;Jaspal S. Kooner;Charles Kooperberg;Simin Liu;Kari E. North;Danish Saleheen;Torben Hansen;Oluf Pedersen;Nicholas J. Wareham;Juyoung Lee;Bong-Jo Kim;Iona Y. Millwood;Robin G. Walters;Kari Stefansson;Emma Ahlqvist;Mark O. Goodarzi;Karen L. Mohlke;Claudia Langenberg;Christopher A. Haiman;Ruth J. F. Loos;Jose C. Florez;Daniel J. Rader;Marylyn D. Ritchie;Sebastian Zöllner;Reedik Mägi;Nicholas A. Marston;Christian T. Ruff;David A. van Heel;Sarah Finer;Joshua C. Denny;Toshimasa Yamauchi;Takashi Kadowaki;John C. Chambers;Maggie C. Y. Ng;Xueling Sim;Jennifer E. Below;Philip S. Tsao;Kyong-Mi Chang;Mark I. McCarthy;James B. Meigs;Anubha Mahajan;Cassandra N. Spracklen;Josep M. Mercader;Michael Boehnke;Jerome I. Rotter;Marijana Vujkovic;Benjamin F. Voight;Andrew P. Morris;Eleftheria Zeggini
  • 通讯作者:
    Eleftheria Zeggini
SMIM1 absence is associated with reduced energy expenditure and excess weight.
SMIM1 缺失与能量消耗减少和体重过重有关。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    L. Stefanucci;C. Moslemi;Ana R. Tomé;Samuel Virtue;Guillaume Bidault;Nicholas S. Gleadall;Laura P.E. Watson;Jing E. Kwa;Frances Burden;Samantha Farrow;K. Banasik;Jakob Bay;Jens K. Boldsen;Thorsten Brodersen;S. Brunak;K. Burgdorf;M. A. Chalmer;M. Didriksen;K. M. Dinh;Joseph Dowsett;C. Erikstrup;B. Feenstra;F. Geller;D. Gudbjartsson;Thomas Folkmann Hansen;L. Hindhede;Henrik Hjalgrim;R. L. Jacobsen;Gregor Jemec;B. A. Jensen;Katrine Kaspersen;B. Kjerulff;Lisette J. A. Kogelman;Margit Anita Hørup Larsen;Ioannis Louloudis;A. Lundgaard;Susan;Christina Mikkelsen;Ioanna Nissen;M. Nyegaard;S. Ostrowski;O. B. Pedersen;A. P. Henriksen;P. D. Rohde;K. Rostgaard;Michael Schwinn;Kári Stefánsson;H. Stefánsson;Erik Sørensen;U. Þorsteinsdóttir;L. Thørner;M. Bruun;H. Ullum;T. Werge;D. Westergaard;Ji Chen;Cassandra N. Spracklen;G. Marenne;Arushi Varshney;L. Corbin;J. Luan;Sara M. Willems;Ying Wu;Xiaoshuai Zhang;M. Horikoshi;Thibaud S. Boutin;Reedik Mägi;Johannes Waage;R. Li;Kei Hang Katie Chan;J. Yao;M. D. Anasanti;Audrey Y. Chu;A. Claringbould;Jani Heikkinen;Jaeyoung Hong;J. Hottenga;Shaofeng Huo;Marika Kaakinen;T. Louie;Winfried März;H. Moreno;A. Ndungu;Sarah C. Nelson;I. Nolte;Kari E North;Chelsea K Raulerson;Debashree Ray;Rebecca R. Rohde;Denis Rybin;C. Schurmann;Xueling Sim;L. Southam;I. Stewart;Carol A. Wang;Yujie Wang;Peitao Wu;Weihua Zhang;T. Ahluwalia;Emil V. R. Appel;L. Bielak;Jennifer A. Brody;N. Burtt;Claudia P. Cabrera;B. Cade;Jin;Xiaoran Chai;Li Chang;Chien;Brian H. Chen;K. Chitrala;Yen;H. D. de Haan;G. Delgado;A. Demirkan;Qing Duan;J. Engmann;Segun A. Fatumo;Javier Gayán;Franco Giulianini;Jung Ho Gong;Stefan Gustafsson;Y. Hai;F. Hartwig;Jing He;Y. Heianza;Tao Huang;Alicia Huerta;M. Y. Hwang;Rich Jensen;T. Kawaguchi;K. Kentistou;Young Jin Kim;M. Kleber;I. Kooner;Shuiqing Lai;Leslie A. Lange;C. Langefeld;Marie Lauzon;Man;Symen Ligthart;Jun Liu;M. Loh;J. Long;V. Lyssenko;Massimo Mangino;C. Marzi;May E. Montasser;A. Nag;M. Nakatochi;Damia Noce;R. Noordam;G. Pistis;Michael H. Preuss;Laura Raffield;L. Rasmussen;Steve Rich;N. Robertson;R. Rueedi;Kathleen A. Ryan;S. Sanna;Richa Saxena;Katharina E. Schraut;B. Sennblad;K. Setoh;Albert V Smith;L. Southam;T. Sparsø;R. Strawbridge;F. Takeuchi;Jingyi Tan;S. Trompet;Erik van den Akker;Peter J. van der Most;N. Verweij;Mandy Vogel;Heming Wang;Chaolong Wang;Nan Wang;H. Warren;W. Wen;Tom Wilsgaard;Andrew Wong;Andrew R. Wood;Tian Xie;M. Zafarmand;Jinghua Zhao;Wei Zhao;Najaf Amin;Z. Arzumanyan;A. Astrup;Stephan J. L. Bakker;D. Baldassarre;M. Beekman;R. Bergman;Alain G. Bertoni;Matthias Blüher;L. Bonnycastle;S. R. Bornstein;Don Bowden;Q. Cai;A. Campbell;Harry Campbell;Yi;E. D. de Geus;Abbas Dehghan;Shufa Du;G. Eiriksdottir;Aliki;Mattias Frånberg;C. Fuchsberger;Yutang Gao;A. Gjesing;A. Goel;Sohee Han;C. Hartman;C. Herder;Andrew A. Hicks;Chang;Willa A. Hsueh;S. Ichihara;M. Igase;M. A. Ikram;W. C. Johnson;M. E. Jørgensen;P. Joshi;Rita R. Kalyani;Fouad R. Kandeel;Tomohiro Katsuya;C. Khor;Wieland Kiess;I. Kolčić;T. Kuulasmaa;J. Kuusisto;Kristi Läll;Kelvin Lam;D. A. Lawlor;N. Lee;R. Lemaitre;Honglan Li;Shih;J. Lindström;A. Linneberg;Jianjun Liu;Carlos Lorenzo;Tatsuaki Matsubara;Fumihiko Matsuda;G. Mingrone;Simon P Mooijaart;Sanghoon Moon;Toru Nabika;G. N. Nadkarni;Jerry L. Nadler;M. Nelis;Matthew Neville;Jill M. Norris;Y. Ohyagi;A. Peters;P. Peyser;O. Polašek;Qibin Qi;Dennis Raven;Dermot F. Reilly;Alex Reiner;Fernando Rivideneira;Kathryn Roll;Igor Rudan;C. Sabanayagam;Kevin Sandow;Naveed Sattar;Annette Schürmann;Jinxiu Shi;H. Stringham;Kent D. Taylor;Tanya M. Teslovich;B. Thuesen;P. Timmers;E. Tremoli;Michael Y. Tsai;A. Uitterlinden;Rob M. van Dam;D. van Heemst;A. van Hylckama Vlieg;Jana V. van Vliet;J. Vangipurapu;Henrik Vestergaard;Tao Wang;K. Willems van Dijk;T. Zemunik;G. Abecasis;Linda S. Adair;C. Aguilar;M. Alarcón;Ping An;L. Avilés;Diane M. Becker;Lawrence Beilin;Sven Bergmann;H. Bisgaard;Corrinda Black;M. Boehnke;Eric Boerwinkle;Bernhard O. Böhm;K. Bønnelykke;D. Boomsma;Erwin P. Bottinger;Thomas A. Buchanan;M. Canouil;M. Caulfield;J. Chambers;D. Chasman;Y. Ida Chen;Ching;F. Collins;Adolfo Correa;Francesco Cucca;H. Janaka de Silva;G. Dedoussis;Sölve Elmståhl;Michele K. Evans;E. Ferrannini;L. Ferrucci;Jose C. Florez;Paul W. Franks;T. Frayling;P. Froguel;Bruna Gigante;M. Goodarzi;Penny Gordon;H. Grallert;N. Grarup;S. Grimsgaard;L. Groop;V. Gudnason;Xiuqing Guo;Anders Hamsten;Torben Hansen;C. Hayward;S. Heckbert;B. L. Horta;Wei Huang;Erik Ingelsson;Pankow S. James;M. Jarvelin;J. Jonas;J. Jukema;P. Kaleebu;Robert S. Kaplan;S. Kardia;Norihiro Kato;S. Keinanen;Bong;M. Kivimaki;H. Koistinen;J. Kooner;Antje Körner;Peter Kovacs;Diana Kuh;M. Kumari;Z. Kutalik;Markku Laakso;Timo A. Lakka;L. Launer;K. Leander;Huaixing Li;Xu Lin;Lars Lind;Cecilia M. Lindgren;Simin Liu;R. Loos;Patrik K. E. Magnusson;A. Mahajan;A. Metspalu;D. Mook;T. A. Mori;P. Munroe;I. Njølstad;Jeffrey R. O’Connell;A. Oldehinkel;Ken K. Ong;S. Padmanabhan;Colin N. A. Palmer;Nicholette D. Palmer;Oluf Pedersen;C. Pennell;D. Porteous;P. Pramstaller;M. Province;B. Psaty;Lu Qi;L. Raffel;R. Rauramaa;S. Redline;P. Ridker;F. Rosendaal;T. Saaristo;M. Sandhu;J. Saramies;Neil Schneiderman;Peter E. H. Schwarz;L. Scott;Elizabeth Selvin;Peter Sever;X. Shu;P. Slagboom;K. Small;Blair H. Smith;H. Snieder;T. Sofer;Thorkild I. A. Sørensen;Tim D. Spector;Alice Stanton;C. Steves;Michael Stumvoll;Liang Sun;Y. Tabara;E. Tai;N. Timpson;A. Tönjes;J. Tuomilehto;T. Tusié;Matti Uusitupa;P. van der Harst;Cornelia van Duijn;V. Vitart;P. Vollenweider;Tanja G. M. Vrijkotte;L. Wagenknecht;Mark Walker;Y. X. Wang;Nick J Wareham;R. M. Watanabe;Hugh Watkins;Wen B. Wei;A. R. Wickremasinghe;G. Willemsen;James F. Wilson;Tien Y. Wong;Jer;Anny H. Xiang;L. Yanek;L. Yengo;M. Yokota;E. Zeggini;Wei;A. Zonderman;Jerome I. Rotter;A. Gloyn;M. McCarthy;José E Dupuis;James B. Meigs;Robert A. Scott;I. Prokopenko;Aaron Leong;Ching;Stephen C. J. Parker;K. Mohlke;C. Langenberg;Eleanor Wheeler;Andrew P. Morris;Inês Barroso;U. Võsa;Keith Burling;Lindsay Walker;John Ord;P. Barker;James Warner;Amy Frary;Karola Renhstrom;Sofie Ashford;Jo Piper;Gail Biggs;Wendy N. Erber;Gary J. Hoffman;N. Schoenmakers;Klaus Rieneck;Morten H. Dziegiel;V. Azzu;Michele Vacca;Hugo J Aparicio;Qin Hui;Kelly Cho;Yan V. Sun;Peter W. F. Wilson;Omer A. Bayraktar;Antonio J Vidal;S. Ostrowski;W. Astle;Martin L Olsson;J. Storry;O. B. Pedersen;Willem H. Ouwehand;Krishna Chatterjee;D. Vuckovic;M. Frontini
  • 通讯作者:
    M. Frontini
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
全基因组关联分析为扩张型心肌病的分子病因学提供了深入见解
  • DOI:
    10.1038/s41588-024-01952-y
  • 发表时间:
    2024-11-21
  • 期刊:
  • 影响因子:
    29.000
  • 作者:
    Sean L. Zheng;Albert Henry;Douglas Cannie;Michael Lee;David Miller;Kathryn A. McGurk;Isabelle Bond;Xiao Xu;Hanane Issa;Catherine Francis;Antonio De Marvao;Pantazis I. Theotokis;Rachel J. Buchan;Doug Speed;Erik Abner;Lance Adams;Krishna G. Aragam;Johan Ärnlöv;Anna Axelsson Raja;Joshua D. Backman;John Baksi;Paul J. R. Barton;Kiran J. Biddinger;Eric Boersma;Jeffrey Brandimarto;Søren Brunak;Henning Bundgaard;David J. Carey;Philippe Charron;James P. Cook;Stuart A. Cook;Spiros Denaxas;Jean-François Deleuze;Alexander S. Doney;Perry Elliott;Christian Erikstrup;Tõnu Esko;Eric H. Farber-Eger;Chris Finan;Sophie Garnier;Jonas Ghouse;Vilmantas Giedraitis;Daniel F. Guðbjartsson;Christopher M. Haggerty;Brian P. Halliday;Anna Helgadottir;Harry Hemingway;Hans L. Hillege;Isabella Kardys;Lars Lind;Cecilia M. Lindgren;Brandon D. Lowery;Charlotte Manisty;Kenneth B. Margulies;James C. Moon;Ify R. Mordi;Michael P. Morley;Andrew D. Morris;Andrew P. Morris;Lori Morton;Mahdad Noursadeghi;Sisse R. Ostrowski;Anjali T. Owens;Colin N. A. Palmer;Antonis Pantazis;Ole B. V. Pedersen;Sanjay K. Prasad;Akshay Shekhar;Diane T. Smelser;Sundararajan Srinivasan;Kari Stefansson;Garðar Sveinbjörnsson;Petros Syrris;Mari-Liis Tammesoo;Upasana Tayal;Maris Teder-Laving;Guðmundur Thorgeirsson;Unnur Thorsteinsdottir;Vinicius Tragante;David-Alexandre Trégouët;Thomas A. Treibel;Henrik Ullum;Ana M. Valdes;Jessica van Setten;Marion van Vugt;Abirami Veluchamy;W. M. Monique Verschuren;Eric Villard;Yifan Yang;Folkert W. Asselbergs;Thomas P. Cappola;Marie-Pierre Dube;Michael E. Dunn;Patrick T. Ellinor;Aroon D. Hingorani;Chim C. Lang;Nilesh J. Samani;Svati H. Shah;J. Gustav Smith;Ramachandran S. Vasan;Declan P. O’Regan;Hilma Holm;Michela Noseda;Quinn Wells;James S. Ware;R. Thomas Lumbers
  • 通讯作者:
    R. Thomas Lumbers
Formalising recall by genotype as an ef fi cient approach to detailed phenotyping and causal inference
通过基因型形式化回忆作为详细表型分析和因果推理的有效方法
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    L. Corbin;Vanessa Y. Tan;David A. Hughes;K. Wade;Dirk S. Paul;K. Tansey;Frances Butcher;F. Dudbridge;J. Howson;M. Jallow;Catherine John;N. Kingston;Cecilia M. Lindgren;O. Michael;Donavan;O. Stephen;Rahilly;Michael J. Owen;Colin N. A. Palmer;E. Pearson;Robert A. Scott;D. Heel;John C. Whittaker;Timonthy M Frayling;M. Tobin;L. Wain;George Davey Smith;David M. Evans;Fredrik Karpe;M. McCarthy;J. Danesh;Paul W. Franks;N. Timpson
  • 通讯作者:
    N. Timpson

Cecilia M. Lindgren的其他文献

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{{ truncateString('Cecilia M. Lindgren', 18)}}的其他基金

Project 2 - Deciphering the Molecular Drivers of Common Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches
项目 2 - 使用综合基因组、细胞和表型组方法破译人类不孕症常见形式的分子驱动因素
  • 批准号:
    10463546
  • 财政年份:
    2021
  • 资助金额:
    $ 24.03万
  • 项目类别:

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合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
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重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
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CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
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Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
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BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
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The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
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ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
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快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
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背诵:社区开展研究,通过表达解决不平等问题
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    2024
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