喉气管狭窄中 T 淋巴细胞和成纤维细胞的靶向 mTOR 调节-猫眼课题宝

喉气管狭窄中 T 淋巴细胞和成纤维细胞的靶向 mTOR 调节

批准号：

10613459

负责人：

Alexander Hillel

金额：

$71.11万

依托单位：

JOHNS HOPKINS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

未结题

起止时间：

2020-05-01 至 2025-04-30

来源：

https://reporter.nih.gov/project-details/10613459

关键词：

Airway Disease Attenuated Autologous Biocompatible Materials Biological Models Breathing CD4 Positive T Lymphocytes Cell Communication Cells Chronic Disease Chronic Obstructive Pulmonary Disease Cicatrix Clinical Trials Coculture Techniques Collaborations Collagen Communication Disability Coronary Data Dedications Development Diabetes Mellitus Disease Dysphonia Engineering FDA approved FOXP3 gene FRAP1 gene Faculty Fibroblasts Fibrosis Flow Cytometry Funding Gene Expression Head and Neck Surgery Histopathology Homeostasis Human Iatrogenesis Immune In Vitro Individual Intubation Laboratories Laryngeal Diseases Larynx Mediating Medical Metabolic Metabolism Methods Mus National Institute on Deafness and Other Communication Disorders Otolaryngology Pathogenesis Pathologic Pathologic Processes Patient Participation Patients Persons Pharmaceutical Preparations Phenotype Pilot Projects Population Proliferating Regenerative Medicine Regulation Regulatory T-Lymphocyte Research Research Personnel Research Project Grants Role Scientist Sirolimus Site Sorting Specimen Stenosis Stents Surgical Management T cell differentiation T-Lymphocyte T-Lymphocyte Subsets Techniques Testing Therapeutic Effect Trachea Tracheostomy procedure Tube Validation Work airway obstruction cell growth clinical practice cost cytokine design druggable target efficacy evaluation improved in vivo in vivo Model mTOR Inhibitor mTOR inhibition mTOR protein medical schools member mortality mouse model novel novel strategies novel therapeutics pre-clinical prevent restenosis side effect single cell mRNA sequencing single cell sequencing translation to humans wound healing

项目摘要

项目成果

Alexander Hillel的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Dr. Alexander Hillel is a faculty member in the Department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine where his clinical practice is dedicated to the medical and surgical management of laryngotracheal stenosis. With the support of a R01 Research Project Grant, he seeks to better understand mechanisms of laryngotracheal stenosis (LTS) and apply regenerative medicine techniques to its treatment. Specifically, Dr. Hillel will be focusing on the mTOR mechanism and targeted inhibition of mTOR as a novel approach to treating LTS in vitro on human LTS-scar fibroblasts and in vivo in a validated mouse model of LTS. This proposal will study the mechanism of how mTOR suppression works on the pathologic T-cell and fibroblast subsets that are critical to the development of iLTS. It also will study how the dysregulated T-cell subsets interact with healthy and diseased fibroblasts to understand the pathogenesis of this devastating disease. Finally, the proposal will test a novel drug eluting stent to deliver mTOR suppression directly to the site of disease in the larynx and trachea to target diseased T-cells and fibroblasts without side effects of systemic mTOR inhibition. Through a combination of in vitro and in vivo modeling, participation from patients with iLTS, and a novel biomaterials approach, the investigator team is uniquely poised to transform our understanding and treatment of LTS. Preclinical validation of mTOR inhibition as a treatment for LTS is a critical step prior to translation to human studies.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文