Novel Metabolic Actions of HDL with Therapeutic Potential for Type 2 Diabetes

HDL 的新代谢作用具有治疗 2 型糖尿病的潜力

• 批准号: nhmrc : 586626
• 负责人: A/Pr Barbora De Courten
• 金额: $ 37.31万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-metabolic-actions-2-diabetes/98649
• 关键词: Novel; Metabolic; Actions; HDL; Therapeutic

Our proposal investigates a novel approach to treat type 2 (late onset) diabetes. We have identified an important link between HDL (good) cholesterol and glucose metabolism. The current proposal is to conduct studies in humans to determine whether therapies which increase HDL result in sustained reduction of blood glucose. Given the escalating global prevalence of obesity and type 2 diabetes, this work is potentially of great significance.

我们的提案研究了一种治疗2型（迟发性）糖尿病的新方法。我们已经确定了HDL（好）胆固醇和葡萄糖代谢之间的重要联系。目前的建议是在人类中进行研究，以确定增加HDL的治疗是否会导致血糖持续降低。鉴于肥胖和2型糖尿病在全球的流行率不断上升，这项工作可能具有重要意义。