CORE C Rabadan

核心C拉巴丹

• 批准号: 10614999
• 负责人: Raul Rabadan
• 金额: $ 15.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-08 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614999
• 关键词: Biometry; Calibration; Chromatin; Chromosomal translocation; Classification; Collaborations; Computational Technique; Computing Methodologies; DNA Double Strand Break; DNA Repair; DNA Sequence Alteration; Data; Data Analyses; Data Set; Development; Double Strand Break Repair; Epigenetic Process; Genetic Transcription; Genomics; Germ-Line Mutation; Goals; Leadership; Learning; Machine Learning; Malignant Neoplasms; Mathematics; Methods; Modeling; Mutation; Physics; Point Mutation; Portraits; Positioning Attribute; Productivity; Research; Role; Scientist; Source; Structure; Techniques; Technology; Testing; Training; Universities; XCL1 gene; analysis pipeline; blind; complex data; computational pipelines; computer science; data integration; deep learning; experimental study; genome-wide; genomic data; insertion/deletion mutation; member; novel; statistics; theories; tool; training opportunity; transcriptomics; tumor; whole genome

Summary Genomic techniques are revolutionizing the characterization of DNA alterations in cancer and their relation to different DNA repair mechanisms. The Computational Genomics Core provides a centralized structure to collect, analyzed and integrate data from all four projects. In addition to current already implemented computational pipelines, the core will develop new techniques that will be applied across projects, it will implement methods for data integration, provide quantitative training and advise in statistical questions.

总结 基因组技术正在彻底改变癌症中DNA改变的特征， 它们与不同的DNA修复机制的关系。计算基因组学核心提供了 集中的结构，收集，分析和整合所有四个项目的数据。除了 目前已经实现的计算管道，核心将开发新的技术， 将应用于各个项目，它将实现数据集成的方法，提供定量的 在统计问题上提供培训和咨询。