Midcareer Investigator Award in Patient-Oriented Research in Aging

以患者为导向的老龄化研究中职业生涯调查员奖

• 批准号: 10615121
• 负责人: ANNE R CAPPOLA
• 金额: $ 16.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615121
• 关键词: Adult; Adverse effects; Age; Aging; American; Award; Blood Tests; Cardiovascular system; Cementation; Cessation of life; Clinical; Clinical Investigator; Clinical Sciences; Collaborations; Communities; Confidence Intervals; Coronary heart disease; Data; Dedications; Dementia; Development; Diagnosis; Dose; Drug Prescriptions; Elderly; Electronic Health Record; Electronic Publishing; Endocrine; Endocrinology; Environment; Faculty; Frequencies; Funding; Generations; Geriatrics; Goals; Health; Health Care Costs; Health system; Hip Fractures; Hypothyroidism; Iatrogenesis; Impaired cognition; Individual; Institution; K-Series Research Career Programs; Leadership; Learning; Left; Longevity; Medicare; Medicine; Mentors; Mentorship; Meta-Analysis; Metadata; Midcareer Investigator Award in Patient-Oriented Research; Monitor; Outcome; Outpatients; Participant; Pattern; Pennsylvania; Persons; Pharmaceutical Preparations; Physical Function; Placebos; Population; Population Distributions; Prevalence; Prevention; Productivity; Publications; Reference Values; Research; Research Personnel; Risk; Risk Reduction; Sample Size; Specificity; Stroke; Symptoms; Testing; Therapeutic; Thyroid Gland; Thyroid Hormones; Thyrotoxicosis; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Time; Training; Translational Research; Universities; Update; age group; age stratification; aged; biomedical informatics; cardiovascular risk factor; care costs; career development; clinical investigation; cognitive testing; human old age (65+); improved; individual patient; individual response; medical schools; metabolic rate; mortality; normal aging; overtreatment; patient oriented; patient oriented research; professor; programs; research study; skills; success

Project Summary This is an application for the renewal of a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has had a strong record of mentorship, leadership, and research productivity during the initial award period. Her research program encompasses POR studies at the intersection of endocrinology and geriatrics. The scientific goals of this proposal are to investigate the age- specificity of the cardiovascular risks of mild subclinical hypothyroidism and to examine thyroid stimulating hormone (TSH) testing and levothyroxine prescribing patterns in older individuals. These studies are required to support a change in the upper limit of the TSH reference range for individuals aged 65 years and older. This change would improve the health and reduce health care costs for millions of older Americans through prevention of unnecessary prescription of thyroid hormone treatment, reduction in excessive TSH monitoring, and avoidance of iatrogenic thyrotoxicosis. The mentoring goals of this application are to support the candidate’s six current K-award mentees’ transition to R01 funded independence and to engage a new generation of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate’s professional development and program building in clinical investigation. This will be achieved through focused learning about biomedical informatics, engagement in Penn’s CTSA to enhance lifespan research, and ongoing leadership to promote the visibility of aging research in the endocrine community. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn’s CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate’s sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct POR in older participants. Renewal of this application will allow the candidate to cement the programmatic gains achieved during the initial award period and to assure their sustainability after the renewal has completed.

项目总结

项目成果

Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies.

• DOI: 10.3389/fpsyt.2022.774251
• 发表时间: 2022
• 期刊: Frontiers in psychiatry
• 影响因子: 4.7
• 作者: Syrogiannouli L;Wildisen L;Meuwese C;Bauer DC;Cappola AR;Gussekloo J;den Elzen WPJ;Trompet S;Westendorp RGJ;Jukema JW;Ferrucci L;Ceresini G;Åsvold BO;Chaker L;Peeters RP;Imaizumi M;Ohishi W;Vaes B;Völzke H;Sgarbi JA;Walsh JP;Dullaart RPF;Bakker SJL;Iacoviello M;Rodondi N;Del Giovane C
• 通讯作者: Del Giovane C

Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism.

• DOI: 10.3389/fendo.2021.795492
• 发表时间: 2021
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Gencer B;Cappola AR;Rodondi N;Collet TH
• 通讯作者: Collet TH

Using Natural Language Processing to Extract and Classify Symptoms Among Patients with Thyroid Dysfunction.

使用自然语言处理对甲状腺功能障碍患者的症状进行提取和分类。

• DOI: 10.3233/shti231038
• 发表时间: 2024
• 期刊: Studies in health technology and informatics
• 作者: Hwang,Sy;Reddy,Sujatha;Wainwright,Katherine;Schriver,Emily;Cappola,Anne;Mowery,Danielle
• 通讯作者: Mowery,Danielle

Barriers to and solutions for representative inclusion across the lifespan and in life course research: The need for structural competency highlighted by the COVID-19 pandemic.

• DOI: 10.1017/cts.2022.510
• 发表时间: 2023
• 期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
• 影响因子: 2.6
• 作者: LeCroy, Madison N.;Potter, Lindsey N.;Bandeen-Roche, Karen;Bianco, Monica E.;Cappola, Anne R.;Carter, Ebony B.;Dayan, Peter S.;Eckstrom, Elizabeth;Edwards, Dorothy F.;Farabi, Sarah S.;Fisher, Sheehan D.;Giordano, Judy;Hanson, Heidi A.;Jenkins, Emerald;Juhn, Young;Kaskel, Frederick;Stake, Christine E.;Reeds, Dominic N.;Schleiss, Mark R.;Wafford, Q. Eileen;McColley, Susanna A.
• 通讯作者: McColley, Susanna A.

Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies.

• DOI: 10.1530/eje-22-0523
• 发表时间: 2022-11-01
• 期刊: European journal of endocrinology
• 影响因子: 5.8
• 作者: Alwan H;Villoz F;Feller M;Dullaart RPF;Bakker SJL;Peeters RP;Kavousi M;Bauer DC;Cappola AR;Yeap BB;Walsh JP;Brown SJ;Ceresini G;Ferrucci L;Gussekloo J;Trompet S;Iacoviello M;Moon JH;Razvi S;Bensenor IM;Azizi F;Amouzegar A;Valdés S;Colomo N;Wareham NJ;Jukema JW;Westendorp RGJ;Kim KW;Rodondi N;Del Giovane C
• 通讯作者: Del Giovane C