Midcareer Investigator Award in Patient-Oriented Research in Aging
Midcareer Investigator Award in Patient-Oriented Research in Aging
批准号:
10615121
负责人:
ANNE R CAPPOLA
金额:
$16.19万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
未结题
起止时间:
2013-07-15 至 2025-04-30
关键词:
AdultAdverse effectsAgeAgingAmericanAwardBlood TestsCardiovascular systemCementationCessation of lifeClinicalClinical InvestigatorClinical SciencesCollaborationsCommunitiesConfidence IntervalsCoronary heart diseaseDataDedicationsDementiaDevelopmentDiagnosisDoseDrug PrescriptionsElderlyElectronic Health RecordElectronic PublishingEndocrineEndocrinologyEnvironmentFacultyFrequenciesFundingGenerationsGeriatricsGoalsHealthHealth Care CostsHealth systemHip FracturesHypothyroidismIatrogenesisImpaired cognitionIndividualInstitutionK-Series Research Career ProgramsLeadershipLearningLeftLongevityMedicareMedicineMentorsMentorshipMeta-AnalysisMetadataMidcareer Investigator Award in Patient-Oriented ResearchMonitorOutcomeOutpatientsParticipantPatternPennsylvaniaPersonsPharmaceutical PreparationsPhysical FunctionPlacebosPopulationPopulation DistributionsPrevalencePreventionProductivityPublicationsReference ValuesResearchResearch PersonnelRiskRisk ReductionSample SizeSpecificityStrokeSymptomsTestingTherapeuticThyroid GlandThyroid HormonesThyrotoxicosisThyrotropinThyrotropin-Releasing HormoneThyroxineTimeTrainingTranslational ResearchUniversitiesUpdateage groupage stratificationagedbiomedical informaticscardiovascular risk factorcare costscareer developmentclinical investigationcognitive testinghuman old age (65+)improvedindividual patientindividual responsemedical schoolsmetabolic ratemortalitynormal agingovertreatmentpatient orientedpatient oriented researchprofessorprogramsresearch studyskillssuccess
中文摘要
项目摘要
这是安妮为患者导向研究(POR)续签K24指导奖的申请书
卡波拉,医学博士,SCM,华盛顿大学佩雷尔曼医学院医学教授
宾夕法尼亚州(宾州)。这位候选人在指导、领导和研究方面都有很好的记录
在初始奖励期间的工作效率。她的研究项目包括在
内分泌学和老年病学的交叉学科。这项提议的科学目标是调查年龄-
轻度亚临床甲状腺功能减退症心血管风险的特异性及甲状腺刺激性检查
老年个体的激素(TSH)测试和左旋甲状腺素处方模式。这些研究是必需的
支持更改65岁及以上个人的TSH参考范围上限。这
改变将通过以下方式改善数百万美国老年人的健康状况并降低医疗成本
防止不必要的甲状腺激素治疗处方,减少过量的TSH监测,
以及避免医源性甲状腺毒症。此应用程序的指导目标是支持
候选人目前的六名K奖学员过渡到R01资助的独立性并聘用新的
一代宾夕法尼亚大学研究员和初级教员在老龄化中进行POR。该公司的职业发展目标是
应用是为了支持候选人在临床上的专业发展和项目建设
调查。这将通过集中学习生物医学信息学、参与
宾夕法尼亚大学的CTSA将加强寿命研究,并持续发挥领导作用,促进老龄化研究的可见度
在内分泌界。宾夕法尼亚大学临床和转化科学的机构环境是
优秀,该提案整合了宾夕法尼亚大学CTSA的多个项目。医学系位于
宾夕法尼亚大学已经做出了实质性的承诺,包括保护时间和专门的空间,以
作为一名以患者为中心的研究人员,候选人持续取得成功,负责培训新一代
对年长参与者进行POR的初级调查人员。续订此申请将允许应聘者
巩固在最初授标期间取得的方案成果并确保其可持续性
在续订完成后。
英文摘要
Project Summary
This is an application for the renewal of a K24 mentoring award for patient-oriented research (POR) from Anne
Cappola, MD, ScM, Professor of Medicine at the Perelman School of Medicine at the University of
Pennsylvania (Penn). The candidate has had a strong record of mentorship, leadership, and research
productivity during the initial award period. Her research program encompasses POR studies at the
intersection of endocrinology and geriatrics. The scientific goals of this proposal are to investigate the age-
specificity of the cardiovascular risks of mild subclinical hypothyroidism and to examine thyroid stimulating
hormone (TSH) testing and levothyroxine prescribing patterns in older individuals. These studies are required
to support a change in the upper limit of the TSH reference range for individuals aged 65 years and older. This
change would improve the health and reduce health care costs for millions of older Americans through
prevention of unnecessary prescription of thyroid hormone treatment, reduction in excessive TSH monitoring,
and avoidance of iatrogenic thyrotoxicosis. The mentoring goals of this application are to support the
candidate’s six current K-award mentees’ transition to R01 funded independence and to engage a new
generation of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this
application is to support the candidate’s professional development and program building in clinical
investigation. This will be achieved through focused learning about biomedical informatics, engagement in
Penn’s CTSA to enhance lifespan research, and ongoing leadership to promote the visibility of aging research
in the endocrine community. The institutional environment for clinical and translational science at Penn is
outstanding, and the proposal integrates multiple programs from Penn’s CTSA. The Department of Medicine at
Penn has made a substantial commitment, including protected time and dedicated space, toward the
candidate’s sustained success as a patient-oriented researcher responsible for training a new generation of
junior investigators who conduct POR in older participants. Renewal of this application will allow the candidate
to cement the programmatic gains achieved during the initial award period and to assure their sustainability
after the renewal has completed.
期刊论文(15)
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DOI:
10.3389/fpsyt.2022.774251
发表时间:
2022
期刊:
Frontiers in psychiatry
影响因子:
4.7
作者:
[Syrogiannouli L, Wildisen L, Meuwese C, Bauer DC, Cappola AR, Gussekloo J, den Elzen WPJ, Trompet S, Westendorp RGJ, Jukema JW, Ferrucci L, Ceresini G, Åsvold BO, Chaker L, Peeters RP, Imaizumi M, Ohishi W, Vaes B, Völzke H, Sgarbi JA, Walsh JP, Dullaart RPF, Bakker SJL, Iacoviello M, Rodondi N, Del Giovane C]
通讯作者:
Del Giovane C
DOI:
10.3389/fendo.2021.795492
发表时间:
2021
期刊:
Frontiers in endocrinology
影响因子:
5.2
作者:
[Gencer B, Cappola AR, Rodondi N, Collet TH]
通讯作者:
Collet TH
Using Natural Language Processing to Extract and Classify Symptoms Among Patients with Thyroid Dysfunction.
使用自然语言处理对甲状腺功能障碍患者的症状进行提取和分类。
DOI:
10.3233/shti231038
发表时间:
2024
期刊:
Studies in health technology and informatics
影响因子:
--
作者:
[Hwang,Sy, Reddy,Sujatha, Wainwright,Katherine, Schriver,Emily, Cappola,Anne, Mowery,Danielle]
通讯作者:
Mowery,Danielle
DOI:
10.1017/cts.2022.510
发表时间:
2023
期刊:
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
影响因子:
2.6
作者:
[LeCroy, Madison N., Potter, Lindsey N., Bandeen-Roche, Karen, Bianco, Monica E., Cappola, Anne R., Carter, Ebony B., Dayan, Peter S., Eckstrom, Elizabeth, Edwards, Dorothy F., Farabi, Sarah S., Fisher, Sheehan D., Giordano, Judy, Hanson, Heidi A., Jenkins, Emerald, Juhn, Young, Kaskel, Frederick, Stake, Christine E., Reeds, Dominic N., Schleiss, Mark R., Wafford, Q. Eileen, McColley, Susanna A.]
通讯作者:
McColley, Susanna A.
DOI:
10.1530/eje-22-0523
发表时间:
2022-11-01
期刊:
European journal of endocrinology
影响因子:
5.8
作者:
[Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Bensenor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C]
通讯作者:
Del Giovane C
共 9 条
Levothyroxine Dosing in Older Individuals
-
批准号:10638015
-
项目类别:
-
资助金额:$59.16万
-
财政年份:2023
-
负责人:ANNE R CAPPOLA
-
依托单位:
Developing Oral LT3 Therapy for Heart Failure
-
批准号:10026340
-
项目类别:
-
资助金额:$77.0万
-
财政年份:2019
-
负责人:ANNE R CAPPOLA
-
依托单位:
Developing Oral LT3 Therapy for Heart Failure
-
批准号:10164851
-
项目类别:
-
资助金额:$75.58万
-
财政年份:2019
-
负责人:ANNE R CAPPOLA
-
依托单位:
Developing Oral LT3 Therapy for Heart Failure
-
批准号:10400936
-
项目类别:
-
资助金额:$66.33万
-
财政年份:2019
-
负责人:ANNE R CAPPOLA
-
依托单位:
Midcareer Investigator Award in Patient-Oriented Research in Aging
-
批准号:8510209
-
项目类别:
-
资助金额:$18.19万
-
财政年份:2013
-
负责人:ANNE R CAPPOLA
-
依托单位:
Midcareer Investigator Award in Patient-Oriented Research in Aging
-
批准号:10444914
-
项目类别:
-
资助金额:$16.19万
-
财政年份:2013
-
负责人:ANNE R CAPPOLA
-
依托单位:
Midcareer Investigator Award in Patient-Oriented Research in Aging
-
批准号:10055441
-
项目类别:
-
资助金额:$16.39万
-
财政年份:2013
-
负责人:ANNE R CAPPOLA
-
依托单位:
Midcareer Investigator Award in Patient-Oriented Research in Aging
-
批准号:8699642
-
项目类别:
-
资助金额:$18.19万
-
财政年份:2013
-
负责人:ANNE R CAPPOLA
-
依托单位:
Ghrelin and Strength Training in Frail Elderly
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批准号:8332309
-
项目类别:
-
资助金额:$24.0万
-
财政年份:2011
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负责人:ANNE R CAPPOLA
-
依托单位:
Ghrelin and Strength Training in Frail Elderly
-
批准号:8249657
-
项目类别:
-
资助金额:$20.0万
-
财政年份:2011
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负责人:ANNE R CAPPOLA
-
依托单位:
Subclinical thyroid dysfunction in the elderly
-
批准号:7787072
-
项目类别:
-
资助金额:$25.69万
-
财政年份:2009
-
负责人:ANNE R CAPPOLA
-
依托单位:
Subclinical thyroid dysfunction in the elderly
-
批准号:8236971
-
项目类别:
-
资助金额:$20.68万
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财政年份:2009
-
负责人:ANNE R CAPPOLA
-
依托单位:
Subclinical thyroid dysfunction in the elderly
-
批准号:8039121
-
项目类别:
-
资助金额:$26.94万
-
财政年份:2009
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负责人:ANNE R CAPPOLA
-
依托单位:
Subclinical thyroid dysfunction in the elderly
-
批准号:7655177
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项目类别:
-
资助金额:$46.85万
-
财政年份:2009
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负责人:ANNE R CAPPOLA
-
依托单位:
Subclinical thyroid dysfunction in the elderly
-
批准号:8448143
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项目类别:
-
资助金额:$16.51万
-
财政年份:2009
-
负责人:ANNE R CAPPOLA
-
依托单位:
Hormonal trajectories in aging
-
批准号:7008672
-
项目类别:
-
资助金额:$30.1万
-
财政年份:2006
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负责人:ANNE R CAPPOLA
-
依托单位:
Hormonal trajectories in aging
-
批准号:7367152
-
项目类别:
-
资助金额:$27.74万
-
财政年份:2006
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负责人:ANNE R CAPPOLA
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依托单位:
Hormonal trajectories in aging
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批准号:7183612
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项目类别:
-
资助金额:$30.05万
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财政年份:2006
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负责人:ANNE R CAPPOLA
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依托单位:
Hormonal trajectories in aging
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批准号:7596347
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项目类别:
-
资助金额:$27.62万
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财政年份:2006
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负责人:ANNE R CAPPOLA
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依托单位:
Androgens, Myostatin, and Sarcopenia in Older Women
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批准号:6769822
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项目类别:
-
资助金额:$14.55万
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财政年份:2002
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负责人:ANNE R CAPPOLA
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依托单位:
海外基金