Midcareer Investigator Award in Patient-Oriented Research in Aging

项目摘要 这是一份K24指导奖的延续申请，用于Anne的以患者为导向的研究（POR） Cappola，医学博士，ScM，宾夕法尼亚大学佩雷尔曼医学院医学教授， 宾夕法尼亚州（Penn）。候选人在指导、领导和研究方面有很好的记录 在最初的奖励期间的生产力。她的研究计划包括POR研究， 内分泌学和老年病学交叉学科。这项提案的科学目标是调查年龄- 轻度亚临床甲状腺功能减退症心血管风险的特异性，并检查甲状腺刺激 激素（TSH）测试和左旋甲状腺素处方模式在老年人。这些研究是必需的 支持65岁及以上人群TSH参考范围上限的变更。这 改变将通过以下方式改善数百万美国老年人的健康状况， 防止不必要的甲状腺激素治疗处方，减少过度TSH监测， 和避免医源性甲状腺毒症。此应用程序的指导目标是支持 候选人的六名现任K奖学员过渡到R 01资助的独立性，并聘请一个新的 宾夕法尼亚大学的研究员和初级教师的一代进行老化的POR。本职业发展目标 申请是为了支持候选人的专业发展和临床项目建设 调查这将通过重点学习生物医学信息学，参与 宾夕法尼亚大学的CTSA，以加强寿命研究，并持续领导，以促进老龄化研究的可见性 在内分泌界。宾夕法尼亚大学临床和转化科学的制度环境是 该提案整合了宾夕法尼亚大学CTSA的多个项目。医学系 宾大已经做出了实质性的承诺，包括保护时间和专用空间， 候选人的持续成功，作为一个以病人为导向的研究人员负责培训新一代的 在老年参与者中进行POR的初级研究者。更新此应用程序将允许候选人 巩固最初授标期间取得的方案成果，并确保其可持续性 更新完成后。

Project Summary This is an application for the renewal of a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has had a strong record of mentorship, leadership, and research productivity during the initial award period. Her research program encompasses POR studies at the intersection of endocrinology and geriatrics. The scientific goals of this proposal are to investigate the age- specificity of the cardiovascular risks of mild subclinical hypothyroidism and to examine thyroid stimulating hormone (TSH) testing and levothyroxine prescribing patterns in older individuals. These studies are required to support a change in the upper limit of the TSH reference range for individuals aged 65 years and older. This change would improve the health and reduce health care costs for millions of older Americans through prevention of unnecessary prescription of thyroid hormone treatment, reduction in excessive TSH monitoring, and avoidance of iatrogenic thyrotoxicosis. The mentoring goals of this application are to support the candidate’s six current K-award mentees’ transition to R01 funded independence and to engage a new generation of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate’s professional development and program building in clinical investigation. This will be achieved through focused learning about biomedical informatics, engagement in Penn’s CTSA to enhance lifespan research, and ongoing leadership to promote the visibility of aging research in the endocrine community. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn’s CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate’s sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct POR in older participants. Renewal of this application will allow the candidate to cement the programmatic gains achieved during the initial award period and to assure their sustainability after the renewal has completed.