Midcareer Investigator Award in Patient-Oriented Research in Aging

项目摘要 这是安妮为患者导向研究(POR)续签K24指导奖的申请书 卡波拉，医学博士，SCM，华盛顿大学佩雷尔曼医学院医学教授 宾夕法尼亚州(宾州)。这位候选人在指导、领导和研究方面都有很好的记录 在初始奖励期间的工作效率。她的研究项目包括在 内分泌学和老年病学的交叉学科。这项提议的科学目标是调查年龄- 轻度亚临床甲状腺功能减退症心血管风险的特异性及甲状腺刺激性检查 老年个体的激素(TSH)测试和左旋甲状腺素处方模式。这些研究是必需的 支持更改65岁及以上个人的TSH参考范围上限。这 改变将通过以下方式改善数百万美国老年人的健康状况并降低医疗成本 防止不必要的甲状腺激素治疗处方，减少过量的TSH监测， 以及避免医源性甲状腺毒症。此应用程序的指导目标是支持 候选人目前的六名K奖学员过渡到R01资助的独立性并聘用新的 一代宾夕法尼亚大学研究员和初级教员在老龄化中进行POR。该公司的职业发展目标是 应用是为了支持候选人在临床上的专业发展和项目建设 调查。这将通过集中学习生物医学信息学、参与 宾夕法尼亚大学的CTSA将加强寿命研究，并持续发挥领导作用，促进老龄化研究的可见度 在内分泌界。宾夕法尼亚大学临床和转化科学的机构环境是 优秀，该提案整合了宾夕法尼亚大学CTSA的多个项目。医学系位于 宾夕法尼亚大学已经做出了实质性的承诺，包括保护时间和专门的空间，以 作为一名以患者为中心的研究人员，候选人持续取得成功，负责培训新一代 对年长参与者进行POR的初级调查人员。续订此申请将允许应聘者 巩固在最初授标期间取得的方案成果并确保其可持续性 在续订完成后。

Project Summary This is an application for the renewal of a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has had a strong record of mentorship, leadership, and research productivity during the initial award period. Her research program encompasses POR studies at the intersection of endocrinology and geriatrics. The scientific goals of this proposal are to investigate the age- specificity of the cardiovascular risks of mild subclinical hypothyroidism and to examine thyroid stimulating hormone (TSH) testing and levothyroxine prescribing patterns in older individuals. These studies are required to support a change in the upper limit of the TSH reference range for individuals aged 65 years and older. This change would improve the health and reduce health care costs for millions of older Americans through prevention of unnecessary prescription of thyroid hormone treatment, reduction in excessive TSH monitoring, and avoidance of iatrogenic thyrotoxicosis. The mentoring goals of this application are to support the candidate’s six current K-award mentees’ transition to R01 funded independence and to engage a new generation of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate’s professional development and program building in clinical investigation. This will be achieved through focused learning about biomedical informatics, engagement in Penn’s CTSA to enhance lifespan research, and ongoing leadership to promote the visibility of aging research in the endocrine community. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn’s CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate’s sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct POR in older participants. Renewal of this application will allow the candidate to cement the programmatic gains achieved during the initial award period and to assure their sustainability after the renewal has completed.