Midcareer Investigator Award in Patient-Oriented Research in Aging

描述（由申请人提供）：这是宾夕法尼亚大学（Penn）佩雷尔曼医学院医学副教授Anne Cappola，医学博士，ScM，医学副教授为K24面向患者的研究（POR）指导奖的申请。候选人在指导、领导和研究生产力方面有很强的记录。她的研究项目包括内分泌学和老年病学交叉的转化和POR研究。这项建议的科学目标是研究老年人亚临床甲状腺功能减退症的生理基础和临床后果。候选人的nia资助的R01基金，加上检查甲状腺轴对衰老的适应性的两个新目标，将构成基金培训计划的基础。额外的研究机会可以在候选人的其他正在进行的nih资助的研究中获得。该应用程序的指导目标是参与和支持宾夕法尼亚大学研究员和初级教师的培训

DESCRIPTION (provided by applicant): This is an application for a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, and Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has a strong record of mentorship, leadership, and research productivity. Her research program encompasses translational and POR studies at the intersection of endocrinology and geriatrics. The scientific goal of this proposal is to investigate the physiologi underpinnings and clinical ramifications of subclinical hypothyroidism in the elderly. The candidate's NIA-funded R01 grant, plus two new aims examining the adaptability of the thyroid axis to aging, will form the basis for the training plan of the grant. Additional research opportunities are available in the candidate's other ongoing NIH-funded studies. The mentoring goals of this application are to engage and support the training of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate's professional development and program building in clinical investigation. This will be achieved through engaging in sustained training experiences with two national experts, convening a local retreat on aging research, developing a training grant for POR in aging, and improving the national network of POR research in hormones and human aging. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn's CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate's sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct research in older participants.