Midcareer Investigator Award in Patient-Oriented Research in Aging

以患者为导向的老龄化研究中职业生涯调查员奖

• 批准号: 8699642
• 负责人: ANNE R CAPPOLA
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699642
• 关键词: Affect; Age; Aging; Asparagine; Award; Baltimore; Binding; Biochemical; Biological Assay; Cells; Clinical; Clinical Investigator; Clinical Sciences; Cross-Over Studies; Data; Development; Diagnosis; Dose; Double-Blind Method; Elderly; Endocrinology; Enrollment; Environment; Faculty; Functional disorder; Funding; Generations; Geriatrics; Glycoproteins; Goals; Grant; Health; Hormones; Human; Hypothyroidism; Individual; Knowledge; Lead; Leadership; Longitudinal Studies; Measurement; Medicine; Mentors; Mentorship; Methodology; Midcareer Investigator Award in Patient-Oriented Research; National Institute of Diabetes and Digestive and Kidney Diseases; Normal Statistical Distribution; Observational Study; Outcome; Participant; Pathologic; Pattern; Pennsylvania; Physicians; Pituitary Gland; Population; Preparation; Productivity; Program Development; Publishing; Randomized; Reference Values; Regimen; Reporting; Research; Research Personnel; Sampling; Schedule; Science; Scientist; Tail; Testing; Therapeutic; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Time; Training; Training Support; Translational Research; United States National Institutes of Health; Universities; Visit; Woman; age related; aged; base; bench to bedside; cardiovascular health; career development; clinical investigation; cohort; experience; follow-up; glycosylation; improved; innovation; medical schools; men; multidisciplinary; novel; patient oriented; patient oriented research; pituitary thyroid axis; professor; programs; public health relevance; receptor; research study; skills; success

DESCRIPTION (provided by applicant): This is an application for a K24 mentoring award for patient-oriented research (POR) from Anne Cappola, MD, ScM, and Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn). The candidate has a strong record of mentorship, leadership, and research productivity. Her research program encompasses translational and POR studies at the intersection of endocrinology and geriatrics. The scientific goal of this proposal is to investigate the physiologi underpinnings and clinical ramifications of subclinical hypothyroidism in the elderly. The candidate's NIA-funded R01 grant, plus two new aims examining the adaptability of the thyroid axis to aging, will form the basis for the training plan of the grant. Additional research opportunities are available in the candidate's other ongoing NIH-funded studies. The mentoring goals of this application are to engage and support the training of Penn fellows and junior faculty to conduct POR in aging. The career development goal of this application is to support the candidate's professional development and program building in clinical investigation. This will be achieved through engaging in sustained training experiences with two national experts, convening a local retreat on aging research, developing a training grant for POR in aging, and improving the national network of POR research in hormones and human aging. The institutional environment for clinical and translational science at Penn is outstanding, and the proposal integrates multiple programs from Penn's CTSA. The Department of Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward the candidate's sustained success as a patient-oriented researcher responsible for training a new generation of junior investigators who conduct research in older participants.

描述（由申请人提供）：这是一个K24指导奖的申请，用于以患者为导向的研究（POR），来自Anne Cappola，医学博士，ScM和宾夕法尼亚大学佩雷尔曼医学院医学副教授（Penn）。候选人有很强的指导，领导和研究生产力的记录。她的研究项目包括内分泌学和老年病学交叉点的转化和POR研究。这项建议的科学目标是调查老年人亚临床甲状腺功能减退症的生理基础和临床后果。候选人的NIA资助的R01赠款，加上两个新的目标，检查甲状腺轴的适应性老化，将形成赠款的培训计划的基础。其他研究机会可在候选人的其他正在进行的NIH资助的研究。这个应用程序的指导目标是参与和支持宾夕法尼亚大学研究员和初级教师的培训 在老化过程中进行POR。该申请的职业发展目标是支持候选人在临床研究中的专业发展和项目建设。这将通过与两名国家专家进行持续的培训经验来实现，召开一次关于老龄化研究的地方务虚会，为POR在老龄化方面提供培训补助金，并改善POR在激素和人类老龄化方面的国家网络。宾夕法尼亚大学的临床和转化科学的机构环境非常出色，该提案整合了宾夕法尼亚大学CTSA的多个项目。宾夕法尼亚大学医学部做出了实质性的承诺，包括保护时间和专用空间，以确保候选人作为一名以患者为导向的研究人员持续取得成功，负责培训新一代在老年参与者中进行研究的初级研究人员。