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Brown University Training Program in the Molecular Biology of Aging

布朗大学衰老分子生物学培训项目

基本信息

批准号：
10615773
负责人：
NICOLA NERETTI
金额：
$ 37.5万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10615773
关键词：
Biology of Aging Molecular Biology Training Programs Universities

项目摘要

Aging is a fundamental biological process and age-related diseases are the leading causes of death in modern societies. The Brown University Training Program in the Molecular Biology of Aging (MBoA) aims to train a next generation of scientists to attack the immensely challenging yet important task of understanding and eventually manipulating human aging. In its first 9 years the MBoA had 4 predoctoral slots per year and has operated under the auspices of two existing and well-established graduate programs, the Molecular Biology, Cell Biology and Biochemistry Graduate Program (MCBGP), and the Pathobiology Graduate Program (PBGP). The MBoA has generated much interest and has attracted very talented students. Nineteen trainees have tracked through the MBoA since 2012 with only one attrition (5%). This cohort includes 4 URM students (21%), with 100% retention. Eight students have graduated with an average of 4 papers each, and all remain engaged in research or science- related careers. The MBoA has grown from 13 faculty trainers in 2012, drawn from 6 departments, to 19 current trainers in 8 departments. This escalating interest in the biology of aging is fueled by an increasing realization that many degenerative disorders are profoundly influenced by basic aging processes, and conversely, that many core molecular mechanisms, such as regulation of chromatin, influence aging. Our understanding of aging has reached a watershed in the past 10-15 years that was enabled by the increasing use of invertebrate model organisms; Brown has a strong base of investigators applying these systems to study a diverse array of biological questions. Brown has increased its presence in neuroscience with the 2018 naming of the Carney Institute in Brain Science, generating new hires and heightened interest in aging biology among its faculty. Building on this momentum we propose to increase the number of MBoA trainers to 26 and affiliate the MBoA with 3 additional graduate programs (in neuroscience, molecular pharmacology, and biomedical engineering). We request the continuation of our 4 predoctoral slots and the addition of 2 postdoctoral slots. The MBoA has supported its predoctoral trainees for a period of 2 years, typically in years 2-3, which we propose to continue. We propose to support postdoctoral trainees for 2 years during early stages of their careers (NIH levels 0-3). The MBoA is part of the new Brown Center on the Biology of Aging (founded 2018) which supports a broad array of programming, including a seminar series, local workshops, retreats, a graduate course on aging and an annual symposium, providing many learning, mentoring and networking opportunities for our trainees. The MBoA is fully engaged in initiatives across the University to build and sustain an equitable and inclusive training environment in which a diverse group of trainees will successfully gain quantitative, conceptual, technical and professional skills that will allow them to conduct rigorous and reproducible research. The goal of the MBoA is to provide strong academic, experimental and career mentoring in the current landscape of molecular aging research, and thus equip our trainees with the skills and qualifications to compete in a sustainable and diverse US biomedical workforce.

衰老是一个基本的生物学过程，与年龄相关的疾病是现代人死亡的主要原因。社会。布朗大学衰老分子生物学培训计划（MBOA）旨在培养下一个一代科学家去攻击理解的巨大挑战，但重要的任务，并最终操纵人类衰老在其前9年的MBOA每年有4个博士学位，并已根据两个现有的和完善的研究生课程，分子生物学，细胞生物学和生物化学研究生课程（MCBGP）和病理生物学研究生课程（PBGP）。MBOA已经引起了很大的兴趣，并吸引了非常有才华的学生。19名受训人员跟踪了自2012年以来，MBoA只有一次减员（5%）。该队列包括4名URM学生（21%），保留率为100%。 8名学生毕业，平均每人4篇论文，所有人都继续从事研究或科学- 相关职业。MBOA已经从2012年的13名教师培训师（来自6个部门）发展到目前的19名 8个部门的培训员。人们越来越认识到，许多退行性疾病受到基本衰老过程的深刻影响，相反，许多核心分子机制，如染色质的调节，影响衰老。我们对衰老的理解在过去的10-15年里，由于越来越多地使用无脊椎动物模型，有机体;布朗拥有强大的研究人员基础，应用这些系统研究各种生物问题.布朗增加了其在神经科学领域的存在，2018年命名了卡尼研究所。脑科学，产生新的雇员和提高其教师对衰老生物学的兴趣。在此基础上我们建议将MBoA培训师的数量增加到26名，并将MBoA与另外3名研究生课程（神经科学，分子药理学和生物医学工程）。我们请继续我们的4个博士前的插槽和2个博士后插槽的增加。MBOA支持其博士前实习生为期2年，通常在第2-3年，我们建议继续。我们建议支持博士后学员在其职业生涯的早期阶段（NIH 0-3级）2年。MBOA是一部分新成立的布朗衰老生物学中心（成立于2018年）支持广泛的编程，包括一系列研讨会、地方讲习班、务虚会、老龄问题研究生课程和年度专题讨论会，为学员提供学习、指导和交流的机会。MBOA正在全力投入整个大学的倡议，以建立和维持一个公平和包容的培训环境，其中不同的学员群体将成功地获得定量，概念，技术和专业技能，使他们能够进行严格和可重复的研究。MBOA的目标是提供强大的学术，实验和职业指导，在分子衰老研究的当前景观，从而装备我们的培训生的技能和资格，在一个可持续的和多样化的美国生物医学劳动力的竞争。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Drosophila Kruppel homolog 1 represses lipolysis through interaction with dFOXO.

DOI：
10.1038/s41598-017-16638-1
发表时间：
2017-11-27
期刊：
Scientific reports
影响因子：
4.6
作者：
Kang P;Chang K;Liu Y;Bouska M;Birnbaum A;Karashchuk G;Thakore R;Zheng W;Post S;Brent CS;Li S;Tatar M;Bai H
通讯作者：
Bai H

Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration.