Light triggered materials for on-demand local anesthesia and tissue adhesive dissolution

用于按需局部麻醉和组织粘合剂溶解的光触发材料

• 批准号: 10613962
• 负责人: Wei Zhang
• 金额: $ 6.67万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-10-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10613962
• 关键词: Absence of pain sensation; Acute Pain; Adhesions; Adhesives; Anesthesia procedures; Award; Binding; Biocompatible Materials; Biodistribution; Cessation of life; Chemicals; Chemistry; Cicatrix; Constipation; Crosslinker; Development; Devices; Drug Delivery Systems; Drug Kinetics; Economic Burden; Encapsulated; Excision; Formulation; Glues; Goals; Hematoxylin and Eosin Staining Method; Histologic; In Vitro; Inflammation; Lasers; Light; Local Anesthetics; Local anesthesia; Medical; Mentors; Modeling; Nausea; Nerve; Nerve Block; Operative Surgical Procedures; Opioid; Opioid Analgesics; Pain; Pain management; Particulate; Patients; Pattern; Pharmaceutical Preparations; Phase; Polymers; Positioning Attribute; Prevention; Property; Pruritus; Quality of life; Rattus; Reaction; Science; Series; Social Problems; Source; Stains; Steroids; System; Testing; Tetrazolium; Therapeutic; Time; Tissue Adhesives; Tissues; Training; Treatment Efficacy; Work; addiction; adhesive polymer; biomaterial compatibility; career; career development; chemical binding; chemical bond; chemical conjugate; chronic pain; crosslink; design; efficacy study; empowerment; experience; functional group; immune modulating agents; improved; in vivo; in vivo imaging; innovation; interest; irradiation; light emission; mechanical properties; novel; overdose death; pain relief; physical property; prevent; response; safety study; sciatic nerve; side effect; skills; wound healing

Project Summary Effective control of acute and chronic pain is a major medical challenge related to patients’ quality of life. Treatment with systemic medications is frequently associated with problems, such as addiction, illegal abuse and even death, leading to social problems and economic burden. Local anesthetics are effective alternatives in treating localized pain without clouding the sensorium, and systemic side effects are generally uncommon. During the mentored K99 phase, the PI will design, synthesize and characterize novel light-responsive polymer-local anesthetic conjugates for on-demand local pain treatment. In this design, the local anesthetics will be chemically bound to polymeric carriers in a manner that could only be reversed by photo-triggering. Materials developed in this project will enable a local anesthetic release system, in which after first administration, pain relief will be controllable in real-time by the patient or clinician using a light source (light- emitting diode or laser). When combined with the PI’s background in chemistry and polymer science, the training and results in the mentored phase will empower the PI, in the R00 phase, to further extend the application of light triggerable materials to the design, synthesis and characterization of novel light-responsive tissue adhesives. Most existing tissue adhesives are inconvenient to reposition during the application, remove undesired residue, or correct inadvertent placement of glue in the wrong position. The R00 project will develop tissue adhesive based on crosslinkable multiarmed polymers with photocleavable properties. The material will be dissolvable upon light irradiation, allowing convenient and non-invasive removal of the adhesives. During the award period, the PI will receive training in drug delivery systems, light-responsive materials, in vivo characterizations of materials, and training in career development, which will greatly increase the PI’s breadth of skills experience in biomaterials and prepare him for an independent academic career.

项目总结