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Clinical Core

临床核心

基本信息

批准号：
10614003
负责人：
HILLEL GROSSMAN
金额：
$ 100.75万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10614003
关键词：
Affect Age Alzheimer&apos s Disease Assessment tool Attention Autopsy Biological Biological Markers Brain Clinical Clinical Data Clinical Research Clinical Trials Cognition Cognition Disorders Cognitive Collaborations Communities Cultural Diversity DNA Data Data Collection Data Set Dementia Development Diagnostic Disease Education Elderly Ensure Ethnic Origin Evaluation Fostering Frequencies Genetic Genotype Goals Health system Heterogeneity Image Imaging technology Impaired cognition Impairment Individual Industry Institution Intervention Studies Ligands Methods Minority Groups Minority Participation Neuropsychology Normal Range Observational Study Participant Patients Phenotype Physicians Population Positron-Emission Tomography Postdoctoral Fellow Procedures Protocols documentation Race Recording of previous events Registries Research Research Personnel Research Technics Resources Risk Role Rotation Sampling Services Side Specific qualifier value Specimen Standardization Techniques Tissues Training Underrepresented Populations United States National Institutes of Health Work biomarker development clinical material clinical phenotype clinical translation cognitive testing cohort cooperative study data sharing design disorder risk doctoral student ethnic diversity follow-up genome-wide high standard innovation instrument interest mild cognitive impairment neuroimaging neuropathology normal aging novel outreach patient population pre-clinical programs recruit resilience screening transmission process treatment response

项目摘要

Mount Sinai ADRC (Sano): Clinical Core (Core B) – Research Summary The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of participants of varying ages, clinical presentations, educational attainment, races and ethnicities. This well-characterized cohort supports a broad array of dementia and cognitive research conducted within the ISMMS, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures and collect biomarkers for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into “research-ready” cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in the Biomarker and Genetics Cores; the clinical characterization of brain donations and other specimens disseminated to the Neuropathology Core; clinical and educational expertise to interact with the projects and trainees of the ORE and REC cores. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.

西奈山 ADRC (Sano)：临床核心（核心 B）——研究摘要临床核心提供认知障碍患者临床和生物学特征方面的专业知识丧失和痴呆症以及识别未受损老年人的能力。这种专业知识用于招聘并维持一组不同年龄、临床表现、教育程度、种族和种族。这个特征明确的队列支持广泛的痴呆症和认知研究在 ISMMS、西奈山卫生系统 (MSHS) 和国家倡议（例如国家阿尔茨海默病协调中心 (NACC)、全基因组阿尔茨海默病研究 (GWAS)、阿尔茨海默病疾病合作研究 (ADCS) 和阿尔茨海默病神经影像倡议 (ADNI)。的作用核心是开发和实施临床程序并收集高标准的生物标志物涵盖受影响受试者正常、前驱和各个阶段的老年人特征进入“研究就绪”队列。临床核心提供研究对象、组织和数据与疾病的临床表现、病程、治疗反应相关的临床研究专业知识，和招募可行性，以帮助指导中心内和更广泛的研究的设计和实施在 MSHS 内。在该中心内，临床核心提供了研究的要素：主题和他们参与生物标志物和遗传学核心的临床特征；的临床特征脑捐赠和其他标本分发给神经病理学核心；临床和教育与 ORE 和 REC 核心项目和学员互动的专业知识。核心创新在于开发评估工具；对新人群进行评估；新成像的适应技术进入临床“现实世界”；以及新型、尚未充分研究或重新利用的化合物的临床试验。该核心在向痴呆症研究中代表性不足的群体进行推广方面拥有丰富而成功的历史，此应用程序中内置了继续此操作的规定。该核心积极培训年轻的研究人员和支持其他领域希望研究其临床人群认知的研究人员。