Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY)

摘要 阿片类药物使用障碍（OUD）仍然是一种持续的公共卫生危机和流行病。尽管有强大的国家， 国家和地方公共卫生对这一流行病的反应，阿片类药物过量死亡继续增加; 2020年有91，799例药物过量死亡，由疾病控制和预防中心（CDC）报告， 大多数，68，630（75%）涉及阿片类药物，比2019年增加了38%。阿片类药物过量死亡负担 肯塔基州更高，从2019年（n= 1，036）到2020年（n = 1，688）增加了63%。背景下 不断变化的阿片类药物流行，加上COVID-19大流行带来的挑战， 负责监测和改善人口健康的机构和组织需要及时 州和地方数据，以便就资源分配和有针对性的应对措施做出关键决策。此类决定 通常与一套旨在预防阿片类药物过量死亡的循证实践（EBP）有关。 我们将利用肯塔基州大学（英国）研究的基础设施和方法学专业知识 中心（包括肯塔基州伤害预防和研究中心，药物和酒精研究中心， 和生物医学信息学研究所），沿着从我们的治疗工作中获得的经验， 由国家药物滥用研究所支持的社区研究，以及行动过量数据 由CDC赞助的项目。该项目的具体目标是建立快速行动数据， 肯塔基州阿片类药物反应（RADOR-KY）-一项全州范围内基于人群的综合、近实时监测 一个监视系统，将从多个国家机构获取数据，并实施先进的信息学 用于快速数据处理、数据链接、机器学习和预测分析的算法， 在数据采集和分析结果可用于支持阿片类药物过量预防之间， 控制RADOR-KY将拥有移动的和基于网络的应用程序，以提供即时传播和 访问接近实时的社区或州一级数据、报告和可视化分析，以便与各机构共享， 社区最终用户。RADOR-KY最终用户咨询小组，包括州政府和地方政府的合作伙伴 社区，将指导RADOR-KY报告和可视化功能的开发。雷达- KY将建立可通过RADOR-KY门户访问的纵向数据集，并在HEAL内共享 数据生态系统。实现算法和基于Web的仪表板的编程代码将在 一个公共存储库，以推动缓解美国阿片类药物流行的努力。

Abstract Opioid use disorder (OUD) remains a persistent public health crisis and epidemic. In spite of robust national, state, and local public health responses to the epidemic, opioid overdose deaths continue to increase; of the 91,799 drug overdose deaths in 2020, reported by the Centers for Disease Control and Prevention (CDC), the majority, 68,630 (75%) involved opioids, a 38% increase from 2019. The opioid overdose death burden in Kentucky is even higher, with a 63% increase from 2019 (n=1,036) to 2020 (n=1,688). In the context of the dynamically changing opioid epidemic, complicated by the challenges presented by the COVID-19 pandemic, agencies and organizations responsible for monitoring and improving the health of the population need timely state and local data to make critical decisions on resource allocation and targeted responses. Such decisions are typically related to a set of evidence-based practices (EBPs) aimed at preventing opioid overdose mortality. We will harness the infrastructure and methodological expertise at the University of Kentucky (UK) research centers (incl. the Kentucky Injury Prevention and Research Center, the Center on Drug and Alcohol Research, and the Institute for Biomedical Informatics), along with the experience gained from our work on the HEALing Communities Study supported by the National Institute on Drug Abuse, and the Overdose Data to Action project sponsored by the CDC. The specific aims of this project are to establish the Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY)– an integrated, population-based, near-real time statewide surveillance system that will ingest data from multiple state agencies and implement advanced informatics algorithms for fast data processing, data linkage, machine learning and predictive analytics to shorten the time between data capture and when analytical results are available to support opioid overdose prevention and control. RADOR-KY will have mobile and web-based applications to provide immediate dissemination and access to near-real time community or state level data, reports, and visual analytics to share with agencies and community end-users. RADOR-KY End-user Advisory Group, including partners in state government and local communities, will guide the development of the RADOR-KY reporting and visualization functionality. RADOR- KY will establish a longitudinal dataset accessible thru the RADOR-KY portal and also shared within the HEAL Data Ecosystem. Programming code for implemented algorithms and web-based dashboards will be shared in a public repository to advance the efforts to mitigate the opioid epidemic across the U.S.