A network-based, mixed methods study to identify and support multiple overdose responders and inform overdose prevention interventions

一项基于网络的混合方法研究，旨在识别和支持多个药物过量反应者并为药物过量预防干预措施提供信息

• 批准号: 10590120
• 负责人: Karla D. Wagner
• 金额: $ 203.47万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590120
• 关键词: Address; American; Area; Behavior; COVID-19; Cessation of life; Characteristics; Clinical; Communities; Criminal Justice; Data; Drug usage; Drug user; Effectiveness; Emotional; Ensure; Epidemic; Exposure to; Family member; Fentanyl; Friends; Funding; Geography; Goals; Harm Reduction; Health; Individual; Intervention; Investigation; Investments; Laws; Lead; Life; Measurement; Methods; Modeling; Naloxone; National Institute of Drug Abuse; Network-based; Nevada; Overdose; Personal Satisfaction; Persons; Pharmaceutical Preparations; Policies; Property; Public Health; Research; Resources; Role; Savings; Services; Social Network; Stimulant; Stress; Testing; Time; Training; Training Support; Trauma; Work; acceptability and feasibility; base; behavioral response; burnout; combat; contextual factors; emergency service responder; empowered; experience; improved; member; opioid overdose; overdose death; overdose education; overdose prevention; overdose risk; preventive intervention; programs; recruit; resilience; response; social; social structure; substance use

07. Project Summary The goal of this proposal is to identify strategies to improve the effectiveness and sustainability of overdose education and naloxone distribution (OEND) programs for people who use drugs (PWUD). Research suggests that some PWUD enthusiastically take up the role of “overdose responder”, responding to multiple overdoses over relatively short periods of time. Others, however, respond to few or no overdoses. We seek to determine the individual, social network, and contextual factors that influence overdose response behavior, with the goal of improving support for PWUD who respond to multiple overdoses and identifying intervention targets to improve the overall capacity of PWUD networks to respond to overdoses among their members. To answer these questions, we propose a longitudinal mixed methods study with 300 PWUDs recruited in Reno, Nevada (an understudied Western region), to address the following aims: 1. Identify the individual, social network, and contextual characteristics of OD responders (relative to those who do not carry or do not use the naloxone they have), including substance use behaviors, size and composition of social networks, personal resilience factors, and geographic and socio-structural factors. 2. Qualitatively describe the positive and negative experiences of responding to ODs, and identify (a) the support or services needed by PWUDs to sustainably respond to ODs in their communities, and (b) the barriers to response among those who do not respond or stop responding. 3. Assess feasibility and acceptability of interventions to improve sustainability and wellbeing of responders, and increase initiation of response behavior among non-responders. Supplemental Aim: Collect quantitative and qualitative data to inform an agent-based model (ABM) of PWUD to test how different OEND program delivery strategies could lead to reductions in fatal OD rates.

07. 项目总结