RTI HEAL Harm Reduction Network Coordination Center

项目摘要/摘要 吸毒过量危机的严重程度使人们更加关注一种著名的公共卫生工具 称为减少危害--为减少负面影响而实施的一套战略或计划 与使用阿片类药物和其他物质有关的后果，同时保持对 个人的。认识到减少危害在解决目前的阿片类药物危机方面的重要性，并 更广泛地说，美国国立卫生研究院(NIH)通过帮助结束物质使用障碍 成瘾长期(Hear)倡议，打算启动一个由九项研究组成的减少危害网络(HRN) 项目和协调中心(CC)，以提高对以下项目的有效性和成果的了解 实施减少危害战略。RTI建议担任HRN的CC。以这个身份， RTI将为HRN提供科学、管理和后勤支持，以促进网络协调 和沟通(目标1)。认识到数据统一对减少危害研究的重要性， RTI将促进利益相关者参与的制定通用指标和措施的过程，以支持 修复数据统一、数据基础设施和共享，并提供方法协商(目标2)。 鉴于让利益攸关方的声音参与以充分确定具体国家面临的问题的重要性 并为他们提供基于证据的解决方案，RTI将促进概念驱动的 代表相关危害风险最高的个人和社区的利益攸关方的参与 吸毒(目标3)。为了加速将研究成果转化为实践，RTI将建立一个 促进及时开发和传播翻译产品的研究基础设施； 包括通过以用户为中心的设计制定有效的传播战略(目标4)。我们的CC团队由以下人员领导 多名首席调查员Emmanuel Oga博士和Jessica Cance博士，他们是 美国国立卫生研究院现有的最大规模的多站点治疗努力。更广泛的核心领导者、联合调查人员和科学研究团队 顾问带来了在减少危害、数据协调、统计方法、数据 基础设施开发和管理，以及实施科学。RTI拥有丰富的经验 成功运营CCS并保留物质使用研究、危害方面的大量集体专业知识 减少，以及社区参与，以实施一系列科学和支持活动 网络。RTI CC将提供所需的强大中央操作，以协调全面的 多项目、多管齐下的研究努力，证明了对方法论的理解 综合来自多个来源、不同人群和结果的证据的复杂性。

Project Summary/Abstract The magnitude of the overdose crisis has brought an increased focus to a well-known public health tool referred to as harm reduction—a set of strategies or programs implemented to reduce the negative consequences associated with the use of opioids and other substances while maintaining respect for the individual. Recognizing the importance of harm reduction in addressing the ongoing opioid crisis and substance use disorder more broadly, the National Institutes of Health (NIH), through the Helping to End Addiction Long-term (HEAL) initiative, intends to launch a Harm Reduction Network (HRN) of nine research projects and a Coordination Center (CC) to improve understanding of the effectiveness and outcomes of implementation of harm reduction strategies. RTI proposes to serve as the CC for the HRN. In this capacity, RTI will provide scientific, administrative, and logistical support for the HRN to facilitate network coordination and communication (Aim 1). Recognizing the importance of data harmonization for harm reduction research, RTI will facilitate a stakeholder-engaged process of developing common metrics and measures to support HEAL data harmonization, data infrastructure and sharing, and provide methodology consultations (Aim 2). Given the importance of involving stakeholder voices to adequately identify the problems faced by specific populations and serve them with evidence-based solutions, RTI will facilitate a conceptually driven engagement of stakeholders representing individuals and communities at highest risk for harms associated with drug use (Aim 3). To accelerate the translation of research findings into practice, RTI will establish a research infrastructure that facilitates the timely development and dissemination of translational products, including effective dissemination strategies through user-centered design (Aim 4). Our CC team is led by multiple Principal Investigators Drs. Emmanuel Oga and Jessica Cance, who are experienced leaders of the largest existing NIH HEAL multisite efforts. The broader team of Core leaders, co-investigators, and scientific advisors bring significant expertise in harm reduction, data harmonization, statistical methodology, data infrastructure development and management, and implementation science. RTI has extensive experience successfully running CCs and retains substantive collective expertise in substance use research, harm reduction, and community engagement to implement a portfolio of scientific and support activities for the network. The RTI CC will provide the needed robust central operation to coordinate a comprehensive multiproject, multipronged research endeavor that demonstrates an understanding of the methodological complexities of integrating evidence from multiple sources with diverse populations and outcomes.