Neurodegenerative Changes in Post-Stroke Depression

中风后抑郁症的神经退行性变化

• 批准号: 10592933
• 负责人: Rodrigo Machado Vieira
• 金额: $ 25.14万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10592933
• 关键词: Affect; Anatomy; Antidepressive Agents; Area; Atrophic; Autopsy; Binding; Biological; Brain; Brain Injuries; Brain imaging; Brain region; Clinical; Complication; Data; Diagnosis; Family; Fiber; Funding; Genes; Glycoproteins; Hippocampus (Brain); Human; Infarction; Injury; Ischemic Stroke; Lesion; Limbic System; Magnetic Resonance Imaging; Measures; Mental Depression; Moods; Nerve Degeneration; Neurologic; Pathologic; Patients; Persons; Pilot Projects; Positron-Emission Tomography; Proteins; Proxy; Quality of life; Recovery of Function; Rehabilitation therapy; Reporting; Research; Role; Severities; Site; Stress; Stroke; Synapses; Synaptic Vesicles; Testing; Therapeutic; Thick; Time; Tissues; United States; Wallerian Degeneration; axon injury; base; cerebrovascular; density; depressive symptoms; disability; disability burden; frontal lobe; high reward; high risk; imaging biomarker; imaging study; in vivo; indexing; middle cerebral artery; mortality; neuroimaging; neuron loss; neuropsychiatric symptom; neuropsychiatry; personalized medicine; post stroke; post stroke depression; pre-clinical; radioligand; recruit; research clinical testing; serial imaging; stroke patient; stroke recovery; stroke survivor; stroke victims; synaptic function; tool; white matter

PROJECT SUMMARY Stroke is one of the leading causes of long-term mortality and disability, affecting nearly 800,000 people in the United States each year. Nearly one-third of stroke victims report post-stroke depression (PSD) after a stroke that significantly affects stroke recovery and is associated with an enormous disability burden and poor quality of life. Post-stroke depression (PSD) is a common and severe complication of cerebrovascular stroke, affecting about one-third of stroke survivors. PSD is associated with poor functional recovery from stroke-related disability, mortality, and poor life quality. The diagnosis and treatment decisions are currently based on clinical evaluation; treatments are not tailored to the brain injury. We hypothesize that identifying specific pathological changes in PSD is the first step towards developing personalized treatments for PSD. Evidence suggests brain anatomical changes (i.e, neurodegeneration - volume loss, microstructures, and disconnections) in prefrontal-limbic circuitry remote from primary stroke lesion and may be causally related to PSD. The primary objectives of this pilot project are to investigate the role of prefrontal-limbic anatomy using MRI and will evaluate synaptic density using a state- of-the-art Positron Emission Tomography (PET) imaging-based synaptic marker. We propose anatomical structural changes and synaptic density losses in prefrontal-limbic circuitry as a biological mechanism underlying PSD. The findings from this study will provide preliminary evidence; (1) if neurodegeneration in the mood-related prefrontal-limbic circuitry underlies depression symptoms, and (2) to develop brain circuit-based neurodegeneration markers underlying neuropsychiatric symptoms in stroke.

项目总结