Neurodegenerative Changes in Post-Stroke Depression

中风后抑郁症的神经退行性变化

• 批准号: 10744198
• 负责人: Rodrigo Machado Vieira
• 金额: $ 19.74万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10744198
• 关键词: Affect; Anatomy; Antidepressive Agents; Area; Atrophic; Autopsy; Binding; Biological; Brain; Brain Injuries; Brain imaging; Brain region; Clinical; Complication; Data; Diagnosis; Early Diagnosis; Family; Fiber; Funding; Genes; Glycoproteins; Hippocampus; Human; Infarction; Injury; Ischemic Stroke; Lesion; Limbic System; Magnetic Resonance Imaging; Measures; Mental Depression; Moods; Nerve Degeneration; Neurologic Deficit; Pathologic; Patients; Persons; Pilot Projects; Positron-Emission Tomography; Pre-Clinical Model; Prefrontal Cortex; Proteins; Proxy; Quality of life; Recovery of Function; Rehabilitation therapy; Reporting; Research; Role; Severities; Site; Stress; Stroke; Structure; Synapses; Synaptic Vesicles; Testing; Therapeutic; Thick; Time; Tissues; United States; Wallerian Degeneration; axon injury; density; depressive symptoms; disability; disability burden; frontal lobe; high reward; high risk; imaging biomarker; imaging study; in vivo; indexing; middle cerebral artery; mortality; neuroimaging; neuron loss; neuropsychiatric symptom; neuropsychiatry; personalized medicine; physically handicapped; post stroke; post stroke depression; radioligand; recruit; research clinical testing; serial imaging; stroke patient; stroke recovery; stroke survivor; stroke victims; synaptic function; tool; white matter

PROJECT SUMMARY Stroke is one of the leading causes of long-term mortality and disability, affecting nearly 800,000 people in the United States each year. Nearly one-third of stroke victims report post-stroke depression (PSD) after a stroke that significantly affects stroke recovery and is associated with an enormous disability burden and poor quality of life. Post-stroke depression (PSD) is a common and severe complication of cerebrovascular stroke, affecting about one-third of stroke survivors. PSD is associated with poor functional recovery from stroke-related disability, mortality, and poor life quality. The diagnosis and treatment decisions are currently based on clinical evaluation; treatments are not tailored to the brain injury. We hypothesize that identifying specific pathological changes in PSD is the first step towards developing personalized treatments for PSD. Evidence suggests brain anatomical changes (i.e, neurodegeneration - volume loss, microstructures, and disconnections) in prefrontal-limbic circuitry remote from primary stroke lesion and may be causally related to PSD. The primary objectives of this pilot project are to investigate the role of prefrontal-limbic anatomy using MRI and will evaluate synaptic density using a state- of-the-art Positron Emission Tomography (PET) imaging-based synaptic marker. We propose anatomical structural changes and synaptic density losses in prefrontal-limbic circuitry as a biological mechanism underlying PSD. The findings from this study will provide preliminary evidence; (1) if neurodegeneration in the mood-related prefrontal-limbic circuitry underlies depression symptoms, and (2) to develop brain circuit-based neurodegeneration markers underlying neuropsychiatric symptoms in stroke.

项目总结 中风是导致长期死亡和残疾的主要原因之一，在全世界有近80万人受到影响 美国每年都有。近三分之一的中风患者报告中风后抑郁(PSD) 这严重影响了中风的康复，并与巨大的残疾负担和质量低下有关 生活的一部分。卒中后抑郁(PSD)是脑血管卒中常见而严重的并发症，影响 大约三分之一的中风幸存者。PSD与中风相关残疾的功能恢复不佳有关， 死亡率高，生活质量差。目前的诊断和治疗决策是基于临床评估； 治疗方法并不是针对脑损伤量身定做的。我们假设识别出特定的病理变化 PSD是为PSD开发个性化治疗的第一步。有证据表明大脑解剖 前额叶边缘回路的变化(即，神经变性体积丢失、微结构和连接中断) 远离原发卒中损害，可能与PSD有因果关系。这个试点项目的主要目标是 将使用MRI研究前额叶-边缘解剖的作用，并将使用状态- 最先进的基于正电子发射断层扫描(PET)成像的突触标记。我们建议从解剖学角度 前额叶-边缘环路的结构变化和突触密度丢失是一种潜在的生物学机制 PSD。这项研究的发现将提供初步的证据：(1)如果神经退行性变与情绪有关 前额叶-边缘环路是抑郁症症状的基础，(2)形成基于大脑环路的 卒中神经精神症状潜在的神经变性标记物。