Developing a Quantitative Assessment Tool for Characterizing Social Domains

开发用于表征社会领域的定量评估工具

• 批准号: 10586621
• 负责人: ANTONIO HARDAN
• 金额: $ 56.64万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586621
• 关键词: 3-Dimensional; Accounting; Adoption; Adult; Age; Assessment tool; Brain; Categories; Child; Clinical; Cognitive; Collection; Companions; Development; Diagnosis; Diagnostic; Dimensions; Disease; Equation; Ethnic Origin; Etiology; Face; Feedback; Focus Groups; Foundations; Future; Goals; Health Care Costs; Impairment; Individual; Information Systems; Information Theory; Interview; Investigation; Language; Measurement; Measures; Methodology; Methods; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Outcome; Parents; Participant; Patient Outcomes Assessments; Perception; Persons; Population; Process; Protocols documentation; Psychometrics; Public Health; Race; Reporting; Research; Research Domain Criteria; Research Personnel; Risk; Sampling; Social Functioning; Social Processes; Source; Standardization; Structure; Surveys; Testing; Time; Translations; United States National Institutes of Health; Update; Youth; age group; aged; autism spectrum disorder; base; clinical outcome measures; clinical practice; clinically relevant; computerized; design; diagnostic platform; follow-up; functional MRI scan; indexing; individualized medicine; instrument; mental state; neural network; neurobiological mechanism; neuropsychiatry; personalized medicine; recruit; response; sex; social; social communication; social deficits; theories

Project Summary/Abstract Social deficits occur across a wide array of neuropsychiatric (NPD) and neurodevelopmental (NDD) disorders and contribute to poor outcomes and sizable public health costs. However, the lack of adequate characterization of mechanisms underpinning social impairments by the current categorical diagnostic systems has significantly stifled the development of etiologically based, individually tailored treatments. A fully dimensional alternative to the categorical frameworks offered by the National Institute of Mental Health’s Research Domain Criteria (RDoC) holds particular promise for a better understanding of mechanisms behind social deficits. More specifically, the RDoC initiative operationalizes an initial set of basic, biologically meaningful components that underpin social functioning, and if disrupted, can impede one’s ability to navigate the complexities of the social world. These processes can therefore be used to better understand social deficits seen across NPD/NDD and inform personalization of treatments. However, we currently lack dedicated measures able to comprehensively capture components of social functioning across clinical, at risk and normative populations which has significantly impeded the translation and adoption of this potentially promising framework. Therefore, the overarching aim of this project is to further expand a recently developed RDoC-based social processes scale: The Stanford Social Dimensions Scale (SSDS). The goal is to refine, factorize, validate and establish regression-based norms of the updated SSDS (SSDS-2). We will also aim to construct a preliminary computerized adaptive testing (CAT) version of the SSDS-2 that will enable individually tailored item selection and administration. These objectives will be achieved by: 1) obtaining feedback on a preliminary item bank from experts and parents of children from normative and clinical groups in order to evaluate the content validity, developmental appropriateness and clinical relevance of the items and to guide the item refinement (Specific Aim 1); 2) utilizing advanced psychometric approaches including exploratory structural equation modeling and item response theory on a large online recruited clinically diverse and normative sample to establish the factor structure (Specific Aim 2); 3) confirming factor structure of the SSDS-2, establishing regression based and standardized change norms and constructing a preliminary CAT version (Specific Aim 3); and further validating the SSDS-2 through an in-person multi-method assessment protocol encompassing interview, observational and experimental methodology with a transdiagnostic sample of youth with a range of social abilities and typically developing youth and their parents. An additional goal is to examine the association between the SSDS-2 subdomains with the neural networks subserving corresponding social processes in a transdiagnostic subsample of youth (Specific Aim 4). This project will lay the foundation for future investigations aimed at: (i) extending the new measure to different age groups (2-5 years and adulthood); (ii) developing a companion clinician-rated structured interview, and (iii) testing its utility as a clinical outcome measure.

项目摘要/摘要 社会缺陷发生在一系列神经精神障碍(NPD)和神经发育障碍(NDD)中 并导致糟糕的结果和可观的公共卫生成本。然而，缺乏足够的 当前分类诊断系统对支持社会损害的机制的表征 大大扼杀了以病因为基础的个性化治疗的发展。一个完整的 国家精神卫生研究所提供的分类框架的维度替代 研究领域标准(RDoC)为更好地理解背后的机制提供了特别的希望 社会赤字。更具体地说，RDoC倡议运作了一套基本的、具有生物学意义的 支撑社交功能的组件，如果中断，可能会阻碍一个人驾驭 社会世界的复杂性。因此，这些过程可以用来更好地理解社会赤字 在NPD/NDD中看到，并告知个性化治疗。然而，我们目前缺乏专门的 能够全面捕获临床、有风险和 这严重阻碍了翻译和采用这一潜在的有希望的 框架。因此，本项目的总体目标是进一步扩展最近开发的基于RDoC的 社会过程量表：斯坦福社会维度量表(SSDS)。目标是提炼、分解、验证 并建立了更新的SSDS(SSDS-2)的回归常模。我们还将致力于建设一个 初步计算机化自适应测试(CAT)版本的SSDS-2，将支持单独定制的项目 选拔和管理。这些目标将通过以下方式实现：1)获得对初步项目的反馈 来自规范组和临床组的专家和儿童家长的银行，以评估内容 项目的效度、发展适宜性和临床相关性，并指导项目细化 (具体目标1)；2)利用先进的心理测量方法，包括探索性结构方程 大量网上招募的临床多样化和标准化样本的建模和项目反应理论 建立因素结构(特定目标2)；3)确定SSDS-2的因素结构，建立 基于回归和标准化的变更规范，并构建初步的CAT版本(具体目标3)； 以及通过面对面的多方法评估协议进一步验证SSDS-2，包括 访谈、观察和实验方法与青年的跨诊断样本 社会能力和典型的发展青年及其父母。另一个目标是检查这种关联 SSDS-2子域与神经网络之间的关系，这些神经网络在 青年跨诊断亚样本(具体目标4)。该项目将为今后的调查奠定基础 旨在：(1)将新措施推广到不同的年龄组(2-5岁和成人)；(2)制定 同伴临床医生评级的结构化访谈，以及(Iii)测试其作为临床结果衡量标准的有效性。