Clinical and biologic health trajectories after early life adversity

早年逆境后的临床和生物学健康轨迹

• 批准号: 10615904
• 负责人: Barbara Hirschman Chaiyachati
• 金额: $ 18.24万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615904
• 关键词: Abate; Acceleration; Accounting; Address; Adolescence; Adult; Age; Aging; Attention; Award; Behavioral; Biological; Child; Child Abuse; Child Abuse and Neglect; Child Health; Child Welfare; Childhood; Clinical; Clinical Immunology; Complex; DNA Methylation; Data; Development; Diagnosis; Diagnostic; Dimensions; Dose; Emotional; Environment; Epigenetic Process; Funding; Future; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genomic approach; Genomics; Goals; Grant; Gur; Health; IL6 gene; Immunology; Inflammation; Inflammatory; Intervention; K-Series Research Career Programs; Leadership; Measurable; Measures; Medical; Mental Health; Mentorship; Methylation; Modernization; Morbidity - disease rate; Neurology; Outcome; Paper; Pediatric Hospitals; Pediatric Research; Pediatrics; Pennsylvania; Phenotype; Philadelphia; Physicians; Policies; Population Heterogeneity; Positioning Attribute; Post-Traumatic Stress Disorders; Predisposition; Psyche structure; Psychiatry; Psychopathology; Radiology Specialty; Reporting; Research; Research Personnel; Risk; Role; Sampling; Scientist; Sex Differences; Sexual abuse; Stress; Stressful Event; Supervision; Testing; Training; Translational Research; Trauma; Universities; Work; Writing; biobank; career; childhood adversity; clinical care; cohort; comorbidity; cytokine; developmental psychology; early life adversity; epigenomics; experience; gene environment interaction; genomic data; improved; innovation; insight; longitudinal, prospective study; maltreatment; methylome; mortality; multimodality; neuropsychiatry; pediatric trauma; phenomics; physical abuse; physical conditioning; pleiotropism; polygenic risk score; professor; psychogenetics; sex; skills; systemic inflammatory response; training opportunity; translational genomics; trauma exposure; whole genome

Project Summary/Abstract This career development award details a 5-year training plan to facilitate the transition of Dr. Barbara H. Chaiyachati to an independent career as a physician-scientist studying predictors of mental and physical health of children after trauma with an objective to identify actionable targets of intervention. Experiences of child abuse and neglect place hundreds of thousands of children at risk for negative health outcomes every year in the U.S. Better understanding of proximate mental and physical health predictors after childhood traumatic stressful events (TSE), including predictive role of genetic susceptibility integrated with early biologic embedding by epigenetic age acceleration (EAA) and increased inflammation, may facilitate targeted interventions to ameliorate the spectrum of long-term health burdens. Thus, multimodal phenomic and genomic approaches are needed to elucidate the complex connections between maltreatment and health. The proposed project builds on the diverse clinical and research experiences of the candidate, with mentorship led by Dr. Raquel Gur, the Karl and Linda Rickels Professor of Psychiatry, Neurology and Radiology at the University of Pennsylvania and an expert in neurodevelopmental trajectories, and Dr. Hakon Hakonarson, Professor of Pediatrics at the Children’s Hospital of Philadelphia and an expert in translational genomics. A team of collaborators adds expertise in developmental psychology, basic and clinical immunology, psychiatric genetics, and behavioral epigenomics, with grounding in child abuse clinical care. The research leverages large, ancestry-diverse, adversity-exposed cohorts within established biorepositories to identify measurable, biologically-relevant health predictors after adversity in childhood. Dr. Chaiyachati will conduct phenomic (physical, mental health, systemic inflammation by cytokines) and genomic (whole genome and methylome) assessments. Specifically, Aim 1 is to determine the impact of TSEs and genetic stress sensitivity, as marked by genetic risk for PTSD, on mental and physical health in adolescence; Aim 2 will assess the impact of TSE on epigenetic aging per DNA methylation clocks; and Aim 3 will test for increased inflammation after experiences of maltreatment. Completion of the proposed studies will improve our understanding of mental and physical health trajectories after experiences of trauma. This proposal will also provide the candidate with experience studying phenomic and genomic data, writing grants and scientific papers, and allow her to gain skills requisite for supervision and leadership. Furthermore, this proposal will establish Dr. Chaiyachati’s intersectional research agenda and position her for independence as a physician-scientist.

项目总结/文摘

项目成果

Association between Asthma and Suicidality in 9-12-Year-Old Youths.

• DOI: 10.3390/brainsci12121602
• 发表时间: 2022-11-23
• 期刊: BRAIN SCIENCES
• 影响因子: 3.3
• 作者: Hoffman, Kevin W.;Visoki, Elina;Argabright, Stirling T.;Schultz, Laura M.;Didomenico, Grace E.;Tran, Kate T.;Gordon, Joshua H.;Chaiyachati, Barbara H.;Moore, Tyler M.;Almasy, Laura;Barzilay, Ran
• 通讯作者: Barzilay, Ran

Child Welfare System-Level Factors Associated with All-Cause Mortality Among Children in Foster Care in the United States, 2009-2018.

与美国寄养儿童全因死亡率相关的儿童福利系统层面的因素，2009-2018 年。

• DOI: 10.1177/10775595231177313
• 发表时间: 2023
• 期刊: Child maltreatment
• 影响因子: 5.1
• 作者: Lee,JoyceY;Steelesmith,DanielleL;Chaiyachati,BarbaraH;Kirsch,Jaclyn;Rao,Smitha;Fontanella,CynthiaA
• 通讯作者: Fontanella,CynthiaA