Association between Asthma and Suicidality in 9-12-Year-Old Youths.
Association between Asthma and Suicidality in 9-12-Year-Old Youths.
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DOI：
10.3390/brainsci12121602
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发表时间：
2022-11-23
期刊：
影响因子：
3.3
通讯作者：
Barzilay, Ran
中科院分区：
文献类型：
--
作者：
Hoffman, Kevin W.;Visoki, Elina;Argabright, Stirling T.;Schultz, Laura M.;Didomenico, Grace E.;Tran, Kate T.;Gordon, Joshua H.;Chaiyachati, Barbara H.;Moore, Tyler M.;Almasy, Laura;Barzilay, Ran
目的：青年中的自杀念头和自杀企图是一个日益严重的健康问题，需要更多关于其生物学基础的数据。哮喘是一种常见的青少年慢性炎症性疾病，在青少年和成人人群中与自杀念头和自杀企图有关，但缺乏年幼儿童和早期青少年的数据。我们希望研究哮喘与儿童自杀的关系，考虑到哮喘作为儿童慢性免疫失调的临床相关模型的潜力。方法：利用青少年脑认知发育研究(ABCD)的数据(n=11,876，47.8%女性，基线评估时平均年龄9.9岁，两年随访时平均年龄12.0岁)，我们评估了哮喘与自杀意念和试图通过基线到两年随访的相关性。结果：父母报告定义的哮喘史(n=2282，占研究人群的19.2%)与自杀企图(SA)相关(优势比(OR)=1.44，P=0.01)，即使控制了人口统计学、社会经济因素和环境因素(OR=1.46，P=0.028)，这种相关性仍然显著。控制人口学、社会经济因素和环境因素后，哮喘发作史与自杀意念(SI)和自杀意念(SA)有关(OR=1.27，p=0.042；OR=1.83，p=0.004)。在控制了自我报告的精神病理因素后，哮喘发作与SA的相关性仍然显著(OR=1.92，p=0.004)。哮喘发作总数与SI和SA有关(OR=1.0 3，p=0.043；OR=1.0 6，p=0.0 5)。结论：研究结果表明哮喘与青春期早期的自杀倾向之间存在关联。需要进一步的研究来研究这种关系背后的机制。
Purpose: Suicidal ideation and attempts in youth are a growing health concern, and more data are needed regarding their biological underpinnings. Asthma is a common chronic inflammatory disorder in youth and has been associated with suicidal ideation and attempts in adolescent and adult populations, but data in younger children and early adolescents are lacking. We wished to study associations of asthma with childhood suicidality considering asthma’s potential as a clinically relevant model for childhood chronic immune dysregulation. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD) Study (n = 11,876, 47.8% female, mean age 9.9 years at baseline assessment and 12.0 years at two-year follow-up), we assessed associations between asthma and suicidal ideation and attempts through baseline to two-year follow-up. Results: Asthma history as defined by parent report (n = 2282, 19.2% of study population) was associated with suicide attempts (SA) (odds ratio (OR) = 1.44, p = 0.01), and this association remained significant even when controlling for demographics, socioeconomic factors, and environmental factors (OR = 1.46, p = 0.028). History of asthma attacks was associated with both suicidal ideation (SI) and SA when controlling for demographics, socioeconomic factors, and environmental factors (OR = 1.27, p = 0.042; OR = 1.83, p = 0.004, respectively). The association of asthma attack with SA remained significant when controlling for self-reported psychopathology (OR = 1.92, p = 0.004). The total number of asthma attacks was associated with both SI and SA (OR = 1.03, p = 0.043; OR = 1.06, p = 0.05, respectively). Conclusions: Findings suggest an association between asthma and suicidality in early adolescence. Further research is needed to investigate mechanisms underlying this relationship.
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影响因子：
3.7
作者：
Ganança L;Oquendo MA;Tyrka AR;Cisneros-Trujillo S;Mann JJ;Sublette ME
通讯作者：
Sublette ME
影响因子：
5
作者：
Barzilay R;Moore TM;Calkins ME;Maliackel L;Jones JD;Boyd RC;Warrier V;Benton TD;Oquendo MA;Gur RC;Gur RE
通讯作者：
Gur RE
影响因子：
5.1
作者：
Carbone, Jason T.;Holzer, Katherine J.;Vaughn, Michael G.
通讯作者：
Vaughn, Michael G.
影响因子：
5.6
作者：
Geller RJ;Espinola JA;Fabiano Filho RC;Hasegawa K;Mansbach JM;Sullivan AF;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
4.7
作者：
Barch DM;Albaugh MD;Avenevoli S;Chang L;Clark DB;Glantz MD;Hudziak JJ;Jernigan TL;Tapert SF;Yurgelun-Todd D;Alia-Klein N;Potter AS;Paulus MP;Prouty D;Zucker RA;Sher KJ
通讯作者：
Sher KJ