Community Developed Technology-Based Messaging to Increase SARS-CoV-2 Vaccine Uptake Among People Who Inject Drugs

社区开发了基于技术的消息传递，以增加注射毒品者对 SARS-CoV-2 疫苗的使用

• 批准号: 10615856
• 负责人: Ian David Aronson
• 金额: $ 62.87万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615856
• 关键词: 2019-nCoV; Address; African American; Age; Area; COVID-19; COVID-19 complications; COVID-19 impact; COVID-19 mortality; COVID-19 vaccination; COVID-19 vaccine; Cellular Phone; Charge; Client; Clinical Trials; Collaborations; Communities; Consult; Criminal Justice; Crowding; Data; Death Rate; Dose; Drops; Enrollment; Ensure; Ethnic Origin; Face; Feedback; Fright; Gender; HIV; HIV/HCV; Handwashing; Harm Reduction; Hepatitis A; Hepatitis B Vaccination; Homelessness; Individual; Influenza vaccination; Injecting drug user; Intervention; Interview; Language; Latino; Latino Population; Link; Location; Medical; Methods; New York; New York City; Outcome; Outcome Measure; Participant; Persons; Pharmaceutical Preparations; Phase; Population; Population Intervention; Race; Randomized; Research; Respondent; Risk; SARS-CoV-2 infection; Sampling; Series; Shelter facility; Site; Social Distance; Structure; Substance Use Disorder; Tablet Computer; Tablets; Target Populations; Technology; Testing; Text; Text Messaging; Trust; Tuberculosis; United States; Vaccinated; Vaccination; Vaccines; Virus; Water; Work; automated text message; barrier to testing; community organizations; coronavirus disease; cost; design; ethnic minority population; experience; follow-up; group intervention; health care availability; health disparity; health disparity populations; improved; infection risk; intervention refinement; maltreatment; overdose prevention; peer; primary outcome; racial minority population; randomized, clinical trials; recruit; response; secondary outcome; social stigma; substance use; treatment duration; treatment group; unvaccinated; uptake; vaccine acceptance; vaccine access; vaccine hesitancy; ventilation

Project Summary/Abstract People who inject drugs (PWID) experience disproportionate risk of being infected with SARS-CoV-2, the virus that causes COVID-19. Unfortunately, due to stigma, fear of mistreatment, and other factors, PWID are far less likely to be vaccinated compared to other populations. African American and Latino populations also face disproportionate risk of infection and far greater COVID-19 death rates compared to White populations, yet due to issues including longstanding medical mistrust are also far less likely to vaccinate. For African American and Latino PWID, COVID-related risks increase even further and vaccination becomes even more unlikely. In response, we propose to continue our collaboration with New York Harm Reduction Educators (NYHRE) a prominent New York City community based organization serving African American and Latino PWID. To increase SARS-CoV-2 vaccination among our target population, we will first assemble a community advisory board (CAB) that we will consult at all phases of the project, then conduct a series of qualitative interviews (n=20) to better understand barriers to testing and vaccination among PWID, and how we can potentially address these via technology-based messaging. We will then work with our CAB and additional PWID participants (n=30) to iteratively develop, evaluate, and refine intervention video and text message content in English and Spanish. Next, we will recruit a separate sample of PWID (n=500) via respondent driven sampling to evaluate these newly created intervention materials as part of a clinical trial. Upon enrollment, participants will be offered a free vaccination against SARS-CoV-2. To increase the rigor of our trial, we will only provide our intervention materials to participants who do not accept vaccination when offered (based on current rates of PWID vaccination against influenza we expect the overwhelming majority will decline). Those who do not initially vaccinate will be randomized into one of two intervention groups: a no video group, and a video text group. The no video group will receive weekly text messages designed to address barriers to vaccination identified in formative research. The video text group will receive the same texts, along with links to videos we develop with NYHRE staff and clients to address barriers to SARS-CoV-2 vaccination. Our intervention will track response rates in both groups. Primary outcome measures will be vaccination within the initial weeks following enrollment and the subsequent intervention period by treatment group. Additional outcomes will include vaccination rates by demographic, including race/ethnicity and primary language (i.e. do English speaking participants respond differently to specific intervention components compared to monolingual Spanish speakers). If shown successful this approach can be replicated with additional populations that experience health disparities, and in different languages across the United States.

项目总结/摘要 注射毒品的人（PWID）感染SARS-CoV-2的风险不成比例， 导致新冠肺炎的病毒不幸的是，由于耻辱，害怕虐待和其他因素，PWID 与其他人群相比，接种疫苗的可能性要小得多。非洲裔美国人和拉丁裔人口也 与白色人群相比，他们面临着不成比例的感染风险和更高的COVID-19死亡率， 由于长期存在的医疗不信任等问题，接种疫苗的可能性也大大降低。非洲裔美国 和拉丁裔PWID，COVID相关风险进一步增加，疫苗接种变得更加不可能。 作为回应，我们建议继续与纽约减少伤害教育工作者合作 （NYHRE）是一个著名的纽约市社区组织，为非洲裔美国人和拉丁裔残疾人提供服务。 为了在我们的目标人群中增加SARS-CoV-2疫苗接种，我们将首先召集社区咨询， 我们将在项目的所有阶段咨询CAB，然后进行一系列定性访谈（n=20） 更好地了解PWID中检测和疫苗接种的障碍，以及我们如何解决这些障碍 通过基于技术的消息传递。然后，我们将与CAB和其他PWID参与者（n=30）合作， 反复开发、评估和完善英语和西班牙语的干预视频和文本信息内容。 接下来，我们将通过受访者驱动抽样招募一个单独的PWID样本（n=500），以评估 这些新创建的干预材料作为临床试验的一部分。报名后，参与者将获得 免费接种SARS-CoV-2疫苗。为了增加我们审判的严谨性，我们只会提供我们的干预 向不接受疫苗接种的参与者提供材料（基于目前的PWID疫苗接种率 我们预计绝大多数人会减少）。那些最初没有接种疫苗的人将被 随机分为两个干预组：无视频组和视频文本组。无视频组 将每周收到旨在解决形成性研究中发现的疫苗接种障碍的短信。 视频文本组将收到相同的文本，沿着我们与NYHRE工作人员一起开发的视频链接， 为客户解决SARS-CoV-2疫苗接种的障碍。我们的干预将跟踪两组的反应率。 主要结局指标将是入组后最初几周内的疫苗接种和随后的 治疗组干预时间。其他结果将包括按人口统计的疫苗接种率， 包括种族/民族和主要语言（即讲英语的参与者对特定的 与单语西班牙语使用者相比，干预成分。 如果证明成功，这种方法可以复制与其他人口的经验，健康 差异，以及美国各地不同的语言。