Ultrasenstive vesicle analysis in precancerous pancreatic neoplasm (IPMN)
癌前胰腺肿瘤 (IPMN) 的超灵敏囊泡分析
基本信息
- 批准号:10615899
- 负责人:
- 金额:$ 37.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AgeAssessment toolBiological MarkersBlindedCarcinomaClinicalClinical ManagementClinical TrialsCyst FluidCystic NeoplasmDataDetectionDiseaseDysplasiaEarly DiagnosisEmerging TechnologiesEnzyme-Linked Immunosorbent AssayEvaluationFrequenciesFutureGoalsGuidelinesHigh grade dysplasiaImageImaging technologyIncidental FindingsIndividualLaboratoriesLesionMagnetic Resonance ImagingMalignant - descriptorMalignant neoplasm of pancreasMeasurementMethodsMucinous NeoplasmPancreasPancreatic CystPancreatic cystic neoplasiaPancreatitisPapillaryPathway interactionsPatientsPeriodicalsPlasmaProteinsRecommendationResolutionRisk AssessmentSamplingScreening for cancerSourceSpecimenSurfaceTechniquesTechnologyTestingTimeTrainingUltracentrifugationValidationVesicleanticancer researchbiobankbiomarker signaturebiomarker validationcancer biomarkerscancer cellclinical practicecostdetection limitdetection methoddigitalextracellular vesicleshigh riskimprovedinnovationnew technologynovel markerpancreatic neoplasmperipheral bloodpoint of carepremalignantprospectiveprotein biomarkerstechnology validationtooltumor progression
项目摘要
The detection of intraductal papillary mucinous neoplasms (IPMN), precancerous lesions of the pancreas, is
rising due to the increasing use of high-resolution cross-sectional imaging. These cystic neoplasms have been
shown to evolve from low-grade dysplasia to high-grade dysplasia to invasive carcinoma and are believed to
account for 20-30% of all pancreatic cancers. The management of patients with some forms of IPMN remains
controversial because current technologies are unable to reliably distinguish between low and high risk IPMN.
There is therefore a need to develop better tools to facilitate the management of controversial lesions. The goal
of this proposal is to develop and test an ultra-sensitive DEST method for profiling circulating extracellular vesicles
(EV) shed by high risk IPMN. Specifically, we propose to i) develop and validate new marker sets relevant for IPMN
progression at unprecedented sensitivities (aim 1) and ii) expand and rigorously test the approach for point-of-care
analyses in prospectively collected clinical samples (aim 2). We hypothesize that highly sensitive EV analysis will
shed valuable light on biomarker composition in IPMN, a necessary prerequisite to identify high risk lesions and
early PDAC. The proposed DEST method has the potential to transform IPMN/early PDAC cancer research and
clinical practice.
胰腺导管内乳头状粘液性肿瘤(IPMN),胰腺癌前病变的检测,
由于越来越多地使用高分辨率的横截面成像,这些囊性肿瘤
显示从低度异型增生发展到高度异型增生再到浸润性癌,
占所有胰腺癌的20-30%。某些形式的IPMN患者的管理仍然是
这是有争议的,因为目前的技术无法可靠地区分低风险和高风险的IPMN。
因此,有必要开发更好的工具,以促进有争议的病变的管理。目标
该提案的一个重要目的是开发和测试一种用于分析循环细胞外囊泡的超灵敏DEST方法
(EV)高风险的IPMN。具体而言,我们建议i)开发和验证与IPMN相关的新标记集
以前所未有的敏感性取得进展(目标1),以及ii)扩大和严格测试护理点方法
对前瞻性收集的临床样本进行分析(目标2)。我们假设高灵敏度的EV分析将
揭示了IPMN中生物标志物组成的有价值的信息,这是识别高风险病变的必要先决条件,
早期PDAC所提出的DEST方法有可能改变IPMN/早期PDAC癌症研究,
临床实践
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma.
- DOI:10.1038/s41598-023-37966-5
- 发表时间:2023-07-06
- 期刊:
- 影响因子:4.6
- 作者:Yang, Katherine S.;O'Shea, Aileen;Zelga, Piotr;Liss, Andrew S.;Del Castillo, Carlos Fernandez;Weissleder, Ralph
- 通讯作者:Weissleder, Ralph
Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research.
- DOI:10.1021/acsnano.0c07581
- 发表时间:2020-11-24
- 期刊:
- 影响因子:17.1
- 作者:Chin LK;Son T;Hong JS;Liu AQ;Skog J;Castro CM;Weissleder R;Lee H;Im H
- 通讯作者:Im H
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RALPH WEISSLEDER, MD, PHD其他文献
RALPH WEISSLEDER, MD, PHD的其他文献
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{{ truncateString('RALPH WEISSLEDER, MD, PHD', 18)}}的其他基金
Bioorthogonal probe development for highly parallel in vivo imaging
用于高度并行体内成像的生物正交探针开发
- 批准号:
10596786 - 财政年份:2023
- 资助金额:
$ 37.66万 - 项目类别:
Temporal analysis of the GBM tumor microenvironment during myeloid cell activating therapy
骨髓细胞激活治疗期间 GBM 肿瘤微环境的时间分析
- 批准号:
10704328 - 财政年份:2023
- 资助金额:
$ 37.66万 - 项目类别:
Ultrasenstive vesicle analysis in precancerous pancreatic neoplasm (IPMN)
癌前胰腺肿瘤 (IPMN) 的超灵敏囊泡分析
- 批准号:
10403494 - 财政年份:2020
- 资助金额:
$ 37.66万 - 项目类别:
Single Circulating Vesicle Analysis for Early Cancer Detection
用于早期癌症检测的单循环囊泡分析
- 批准号:
9913496 - 财政年份:2019
- 资助金额:
$ 37.66万 - 项目类别:
Multiplexed analysis of exosomes in cancer nano therapy
癌症纳米疗法中外泌体的多重分析
- 批准号:
9078198 - 财政年份:2016
- 资助金额:
$ 37.66万 - 项目类别:
Multiplexed analysis of exosomes in cancer nano therapy
癌症纳米疗法中外泌体的多重分析
- 批准号:
9487955 - 财政年份:2016
- 资助金额:
$ 37.66万 - 项目类别:
Analysis of scant cancer cells in fine needle aspirates
细针抽吸物中少量癌细胞的分析
- 批准号:
9023623 - 财政年份:2016
- 资助金额:
$ 37.66万 - 项目类别:
Analysis of scant cancer cells in fine needle aspirates
细针抽吸物中少量癌细胞的分析
- 批准号:
9324962 - 财政年份:2016
- 资助金额:
$ 37.66万 - 项目类别:
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