Improving measurement of alcohol consumption among HIV-affected youth in sub-Saharan Africa: evaluation and implementation of biomarkers
改进对撒哈拉以南非洲受艾滋病毒影响的青少年饮酒量的测量:生物标志物的评估和实施
基本信息
- 批准号:10616727
- 负责人:
- 金额:$ 17.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAchievementAddressAdherenceAdolescentAdolescent and Young AdultAdoptionAffectAfrica South of the SaharaAgeAlcohol abuseAlcohol consumptionAlcoholsBackBiological AssayBiological MarkersBody mass indexCaringCessation of lifeCharacteristicsClinicClinical ResearchCollaborationsConsumptionCounselingCountryData CollectionDedicationsDetectionDevelopmentDevelopment PlansDiagnosisDissemination and ImplementationEcological momentary assessmentEffectiveness of InterventionsEpidemicEvaluationEvidence based practiceFeedbackFocus GroupsFollow-Up StudiesFundingGenderGlucuronidesGoalsHIVHIV InfectionsHIV/AIDSHomeIncidenceIncomeInfectious Diseases ResearchInterviewKnowledgeLeadLinkMeasurementMeasuresMentorsMentorshipMethodsMinorityNational Institute on Alcohol Abuse and AlcoholismOutcomePatient Self-ReportPolicy MakerPopulationPredispositionPrevalenceProceduresProcessProfessional counselorProtocols documentationPsychiatric epidemiologyPublic HealthQuality of CareReligionReportingResearchResearch ActivityResearch PersonnelResearch TrainingResource AllocationRiskRoleScientistScreening ResultServicesSocial DesirabilitySocietiesStrategic PlanningTest ResultTestingTrainingTreatment EfficacyTreatment outcomeUnderserved PopulationUnited States National Institutes of HealthUniversitiesUrineViralVisitWorkYouthZambiaalcohol abuse therapyalcohol epidemiologyalcohol interventionalcohol measurementalcohol misusealcohol riskalcohol screeningalcohol servicesalcohol testingbrief interventioncareercareer developmentcatalystclinical practicecostdesigndiagnostic tooleffectiveness evaluationefficacy studyevidence baseexperiencefeasibility testingfollow-upformative assessmentfuture implementationhealth disparityhigh risk sexual behaviorimplementation determinantsimplementation researchimplementation scienceimplementation strategyimplementation/effectivenessimprovedinnovationlaboratory experiencemultidisciplinarynovelphosphatidylethanolpoint-of-care diagnosticspopulation basedprevention serviceprogramsrandomized trialreduced alcohol usescreeningscreening and brief interventionsocial stigmastressortimelinetransmission processtreatment servicesunderage drinkinguptake
项目摘要
HIV-affected adolescents and young adults (AYA) in sub-Saharan Africa (SSA) experience stressors that
increase their risk for problematic alcohol use, which in turn can lead to HIV infection or transmission and poor
HIV outcomes, including linkage to care and ART adherence. Efforts to address the HIV epidemic among
adolescents and young adults in SSA have therefore focused, in part, on treating risky alcohol use. Yet, the
vast majority of HIV-affected AYA in SSA who need alcohol services do not receive them, resulting in a
substantial treatment gap. A critical barrier to the accurate screening for risky alcohol use among AYA and
provision of appropriate treatment is a lack of objective measures for alcohol consumption in HIV care settings,
which rely primarily on self-report alone. This K01 mentored research scientist development proposal aims to
examine the role of biomarkers in improving alcohol screening and treatment referral among AYA in HIV
prevention and treatment clinics. Specifically, the proposal will investigate a urine-based biomarker, ethyl
glucuronide (UEtG), which has displayed potential as a point-of-care diagnostic tool among clinic-based
populations in the U.S. but has not been investigated as a valid and feasible method within HIV care settings
among AYA. Research activities for this proposal will take place in Zambia, a country with one of the highest
HIV prevalence estimates in the world. The research will leverage over a decade of HIV research in Zambia by
Johns Hopkins University and a longstanding collaboration with Centre for Infectious Disease Research in
Zambia (CIDRZ), the local implementing partner. Specific aims of the proposal are to: 1) assess the test
characteristics of UEtG among HIV-affected AYA in Zambia; 2) develop a protocol for the use of rapid UEtG
dip card testing embedded within AYA HIV prevention and treatment; and 3) pilot the UEtG protocol developed
in Aim 2 and refine procedures with a formative evaluation process. Findings will inform implementation
strategies that can be tested in a follow-up study. The research is designed to be an integral component of a
rigorous training and career development plan focused on HIV/AIDS, alcohol biomarkers, and implementation
science. Training will take the form of coursework, lab training, and one-on-one mentorship with an
experienced and dedicated team of multidisciplinary mentors and consultants who are widely considered to be
experts in their respective fields. The goal of the professional development plan is to facilitate the candidate's
transition into an independent investigator in alcohol epidemiology and implementation science with specific
expertise in HIV and biomarkers. The proposal is directly in line with Goal 2 (“improve diagnosis and tracking of
alcohol misuse”) and Objective 5c (“facilitating dissemination and implementation of evidence-based practices
for diagnosing alcohol misuse”) of the NIAAA Strategic plan 2017-2021. The proposal is consistent with NIH
high priority HIV research in addressing “health disparities in the incidence of new HIV infections” and
“research training of the workforce required to conduct high priority HIV/AIDS or HIV/AIDS-related research.”
撒哈拉以南非洲(SSA)受艾滋病毒影响的青少年和青壮年(AYA)面临的压力是
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Two-year treatment effects of the common elements treatment approach (CETA) for reducing intimate partner violence and unhealthy alcohol use in Zambia.
共同元素治疗方法(CETA)的两年治疗效果减少赞比亚的亲密伴侣暴力和不健康的饮酒。
- DOI:10.1017/gmh.2021.2
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Kane JC;Glass N;Bolton PA;Mayeya J;Paul R;Mwenge M;Murray LK
- 通讯作者:Murray LK
Alcohol-focused and transdiagnostic treatments for unhealthy alcohol use among adults with HIV in Zambia: A 3-arm randomized controlled trial.
- DOI:10.1016/j.cct.2023.107116
- 发表时间:2023-04
- 期刊:
- 影响因子:2.2
- 作者:Vinikoor, Michael J.;Sharma, Anjali;Murray, Laura K.;Figge, Caleb J.;Bosomprah, Samuel;Chitambi, Chipo;Paul, Ravi;Kanguya, Tukiya;Sivile, Suilanji;Nghiem, Van;Cropsey, Karen;Kane, Jeremy C.
- 通讯作者:Kane, Jeremy C.
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Jeremy Calvin Kane其他文献
Jeremy Calvin Kane的其他文献
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{{ truncateString('Jeremy Calvin Kane', 18)}}的其他基金
Improving measurement of alcohol consumption among HIV-affected youth in sub-Saharan Africa: evaluation and implementation of biomarkers
改进对撒哈拉以南非洲受艾滋病毒影响的青少年饮酒量的测量:生物标志物的评估和实施
- 批准号:
10400760 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
Improving measurement of alcohol consumption among HIV-affected youth in sub-Saharan Africa: evaluation and implementation of biomarkers
改进对撒哈拉以南非洲受艾滋病毒影响的青少年饮酒量的测量:生物标志物的评估和实施
- 批准号:
10158010 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
FEASIBILITY AND PRELIMINARY EFFECTIVENESS OF A TRANSDIAGNOSTIC COGNITIVE BEHAVIORAL THERAPY TREATMENT APPROACH FOR ALCOHOL MISUSE INTEGRATED WITHIN HIV CARE IN ZAMBIA
赞比亚将酒精滥用跨诊断认知行为疗法纳入艾滋病毒护理的可行性和初步有效性
- 批准号:
10121170 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
Improving measurement of alcohol consumption among HIV-affected youth in sub-Saharan Africa: evaluation and implementation of biomarkers
改进对撒哈拉以南非洲受艾滋病毒影响的青少年饮酒量的测量:生物标志物的评估和实施
- 批准号:
9623507 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
Feasibility and preliminary effectiveness of a transdiagnostic cognitive behavioral therapy treatment approach for alcohol misuse integrated within HIV care in Zambia
赞比亚艾滋病毒护理中针对酒精滥用的跨诊断认知行为疗法的可行性和初步有效性
- 批准号:
9755276 - 财政年份:2018
- 资助金额:
$ 17.54万 - 项目类别:
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