San Diego Digestive Diseases Research Center

圣地亚哥消化疾病研究中心

• 批准号: 10617213
• 负责人: LARS ECKMANN
• 金额: $ 118.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617213
• 关键词: Acceleration; Animal Model; Area; Basic Science; Biomedical Research; California; Cell Culture Techniques; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communication; Complement; Development; Digestive System Disorders; Direct Costs; Disease; Effectiveness; Environment; Faculty; Fostering; Funding; Gastrointestinal Diseases; Gastrointestinal tract structure; Goals; Health; Human; Immune response; Immunity; Individual; Infection; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Response; Infrastructure; Institution; Investments; Laboratory Research; Link; Liver; Liver diseases; Mentors; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Patient Care; Phenotype; Pre-Clinical Model; Prevention; Productivity; R24; Research; Research Personnel; Research Support; Resources; Role; Scientist; Series; Services; Specimen; System; Technology; Translational Research; Universities; Work; base; career; cost effective; design; flexibility; functional genomics; gastrointestinal; high risk; host-microbe interactions; human tissue; improved; innovation; lectures; medical schools; member; microbiome research; mouse model; next generation; novel; patient population; preclinical study; programs; repository; research and development; symposium; web site

Summary The San Diego Digestive Diseases Research Center is founded on a research base of 33 outstanding investigators with current digestive diseases-relevant funding of $15,689,402 in total annual direct costs, of which $5,711,412 (36.4%) are from NIDDK. The overall mission of the Center is to support basic, translational and clinical research that will lead to improved treatment and prevention of inflammatory diseases of the digestive system. The primary goal of the Center is to provide services to the research laboratories of a consortium of four adjacent research institutions in the San Diego area that will foster research productivity and new research directions, and encourage productive collaborations. Another major goal of the San Diego Digestive Diseases Research Center is to enhance new digestive diseases research through Pilot/Feasibility and Enrichment programs. The Center supports three interrelated Biomedical Research Cores that are designed to enhance the research potential and productivity of the Center members. The Human Translational Core builds upon existing expertise in clinical and translational research to provide access to human specimens and leverages unique existing repositories of inflammatory bowel disease and liver diseases. The Preclinical Models Core facilitates and assists in characterizing and understanding of gastrointestinal and liver diseases using murine models. The Microbiomics and Functional Genomics Core provides cutting-edge and cost-effective access to sequencing-based technologies in microbiomics and functional genomics. Furthermore, an Administrative Core supports the Center administratively and coordinates the Pilot/Feasibility and Enrichment programs. Together, these Cores provide high-quality and state-of-the-art research resources to increase collaborative activity and effectiveness of the members, and promote the development of junior investigators. Combined with the Pilot/Feasibility and Enrichment programs, the San Diego Digestive Diseases Research Center will complement a strong cadre of scientists focused on a range of important inflammatory diseases of the gastrointestinal tract and liver. By creating a unique environment to nurture novel research ideas and interactions, the San Diego Digestive Diseases Research Center presents a unique opportunity to integrate clinical and bench research to advance the basic understanding of digestive diseases, and enhance the health and care of patients suffering from those diseases.

总结

项目成果

Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics.

• DOI: 10.3389/fmicb.2022.834008
• 发表时间: 2022
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Krakovka S;Ribacke U;Miyamoto Y;Eckmann L;Svärd S
• 通讯作者: Svärd S

The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites.

• DOI: 10.1099/mgen.0.000402
• 发表时间: 2020-08
• 期刊: Microbial genomics
• 影响因子: 3.9
• 作者: Xu F;Jiménez-González A;Einarsson E;Ástvaldsson Á;Peirasmaki D;Eckmann L;Andersson JO;Svärd SG;Jerlström-Hultqvist J
• 通讯作者: Jerlström-Hultqvist J

Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open-label, long-term extension study with up to 7.0 years of treatment.

• DOI: 10.1111/apt.16712
• 发表时间: 2022-03
• 期刊: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
• 影响因子: 7.6
• 作者: Sandborn, William J.;Lawendy, Nervin;Danese, Silvio;Su, Chinyu;Loftus, Edward V., Jr.;Hart, Ailsa;Dotan, Iris;Damiao, Aderson O. M. C.;Judd, Donna T.;Guo, Xiang;Modesto, Irene;Wang, Wenjin;Panes, Julian
• 通讯作者: Panes, Julian

A Microsimulation Model to Determine the Cost-Effectiveness of Treat-to-Target Strategies for Crohn's Disease.

• DOI: 10.14309/ajg.0000000000001263
• 发表时间: 2021-08-01
• 期刊: The American journal of gastroenterology
• 作者: Dulai PS;Jairath V;Narula N;Wong E;Kochhar GS;Colombel JF;Sandborn WJ
• 通讯作者: Sandborn WJ

Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice.

• DOI: 10.3390/ijms22073544
• 发表时间: 2021-03-29
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Lee J;Mohsen A;Banerjee A;McCullough LD;Mizuguchi K;Shimaoka M;Kiyono H;Park EJ
• 通讯作者: Park EJ