Postdoctoral Training, Neurobiology of Aging and Alzheimer's Disease

项目总结/摘要 提交了题为“衰老和阿尔茨海默病的神经生物学”的博士后培训补助金 通过亚利桑那大学代表亚利桑那州阿尔茨海默氏症联盟。选择的培训教师 由高度互动的研究人员组成，他们的科学兴趣包括衰老， 阿尔茨海默病（AD）和AD相关性痴呆（ADRD），跨越果蝇、啮齿动物和非人灵长类动物 老化模型，以及在正常和病理老化条件下的人类研究。六个机构 在联盟内，为该培训计划贡献主要导师（Preceptors）和附属教师， 包括：亚利桑那大学、亚利桑那州立大学、巴罗神经学研究所、班纳太阳 健康研究所，翻译基因组学研究所和班纳阿尔茨海默氏症研究所。 教师在脑成像，计算机科学，基因组学，分子生物学，基础 系统，行为和认知神经科学，实验治疗学，计算和统计 复杂数据集和临床神经病理学方法的分析。该研究旨在促进 科学认识脑老化，早期发现AD和ADRD，制定有效的 治疗和预防疗法。研究员受益于4人专业发展委员会 (PDC)其目的是为制定合作实验培训计划提供指导， 促进跨机构工作、学习和生产的机会。主要研究导师，在其 实验室的研究员是基于，是从导师名单中选择，因为是次要的研究导师，但他们 可以来自财团中的任何机构。二级导师在以下方面发挥积极作用： 研究员进行的研究，这超出了提供设施。一个三级导师是 根据实验或教学专业知识进行选择，并选择PDC的第四名成员 从6人的领导团队中选出一名成员，以提供额外的监督。接触独特的 亚利桑那州的合作和协作的传统，不知道任何机构的边界， 在培训期间丰富了我们研究员的技能和专业发展。除了 多实验室研究接触，另一个独特的方案方面采取了三个研讨会的形式 每年举行一次为期1-3天的会议，所有研究员都参加。其中包括全州范围内的活动， 教师参加（年度亚利桑那州阿尔茨海默氏症协会务虚会），或教师，研究生和 博士后参加（阿尔茨海默氏症联盟年度科学会议），以及更广泛的参与， 国家和国际专业活动（例如，神经科学学会（Society for Neuroscience）我们的目标是让 研究员，从整个财团的设施和专业知识中广泛借鉴的自由暴露了我们的 学员的协作，跨学科的互动，可以促进发展的强大的力量 实验设计，以测试重要的问题，为生产性的未来工作提供基础。

Project Summary/Abstract The postdoctoral training grant entitled “The Neurobiology of Aging and Alzheimer's Disease” is submitted through the University of Arizona on behalf of the Arizona Alzheimer's Consortium. The training faculty chosen from the Consortium consist of highly interactive investigators whose scientific interests include aging, Alzheimer's disease (AD) and AD-related dementias (ADRD) and spans fly, rodent, and nonhuman primate models of aging, as well as human studies in normative and pathological conditions of aging. Six institutions within the Consortium contribute Primary Mentors (Preceptors) and Affiliate Faculty to this Training Program, including: The University of Arizona, Arizona State University, Barrow Neurological Institute, Banner Sun Health Research Institute, The Translational Genomics Research Institute, and Banner Alzheimer's Institute. Faculty have complementary strengths in brain imaging, computer science, genomics, molecular biology, basic systems, behavioral and cognitive neuroscience, experimental therapeutics, computational and statistical analyses of complex datasets and clinical neuropathological approaches. The research is aimed at promoting the scientific understanding of the aging brain, early detection of AD and ADRD and developing effective treatment and prevention therapies. Fellows benefit from a 4 person Professional Development Committee (PDC) whose purpose is to provide guidance on the creation of a collaborative experimental training plan that fosters opportunities to work, learn and produce across institutions. The primary research Mentor, in whose laboratory the Fellow is based, is chosen from the Preceptor list, as is the secondary research Mentor, but they can be from any institution amongst the consortium. The secondary Mentor plays an active role in the research undertaken by the Fellow, which goes beyond making facilities available. A tertiary Mentor is selected on the basis of experimental or pedagogical expertise, and a fourth member of the PDC is chosen from amongst the 6-person leadership team to provide an additional level of oversight. Exposure to the unique Arizona tradition of cooperation and collaboration that knows no institutional boundaries has significantly enriched the skill sets and professional development of our Fellows during the training period. In addition to multi-laboratory research exposure, another unique programmatic aspect takes the form of three workshops per year, varying from 1-3 days, in which all Fellows participate. These include statewide events that Training Faculty attend (Annual Arizona Alzheimer's Consortium Retreat), or that faculty, graduate students and postdocs attend (Alzheimer's Consortium Annual Scientific Conference), as well as broader participation in national and international professional events (e.g., Society for Neuroscience meeting). Our goal to give the Fellow the freedom to draw broadly from facilities and expertise across the Consortium has exposed our Trainees to the power of collaborative, interdisciplinary interactions that can facilitate development of strong experimental designs to test important questions, providing the foundation for productive future work.