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Comorbidity: Substance Use Disorders and Other Psychiatric Conditions

合并症：药物使用障碍和其他精神疾病

基本信息

批准号：
10617224
负责人：
MATT G KUSHNER
金额：
$ 32.99万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10617224
关键词：
Substance Use Disorder comorbidity

项目摘要

Abstract Introduction: This is a renewal application for T32 institutional training grant application – Comorbidity: Substance Use Disorders and Other Psychiatric Conditions (NIDA DA037183) -- following the completion of its first five-year funding cycle. Among the current portfolio of NIDA funded training grants, only one program other than ours (Dartmouth) has comorbidity as a primary focus. This is striking given co-occurrence prevalence of Substance Use Disorders (SUD) with other psychiatric conditions and health conditions (e.g. diabetes), and the extent to which either SUD or the comorbid disorder can go under- or untreated in conventional treatment settings. The goals, elements and resources of the renewal program retains critical and effective elements of the initial funding period while incorporating important lessons learned. Long term goals: The proposed program will develop a cadre of scientists with research expertise in comorbidity mechanisms, antecedents and correlates, diagnostics, and psychosocial and pharmacological interventions. Component objectives are to provide each trainee with a working knowledge of comorbidity research including: (a) translational science from Early Phase Clinical Trials to Community Based Participatory Research perspectives; (b) effective research strategies for comorbid conditions across populations and ethnic and cultural groups (e.g. American Indian, Hmong, Somali). Accomplishing programmatic features will capitalize on (a) the spectrum of faculty expertise providing mentoring across multiple areas, and (b) integration across training programs and departments. Key Elements: (1) Involvement of scientists and clinicians with diverse expertise and a core internal advisory group. Primary sites (4 postdoctoral trainees, 2 yrs each) are the Departments of Psychiatry and Psychology (UMN Twin Cities) and Family Medicine and Biobehavioral Health (UMN Duluth); (2) Recruitment, including under represented group outreach, of rigorously screened PhD and MD candidates with SUD and comorbidity as primary career focus; (3) Training with an interdisciplinary mentoring team (primary & 2 secondary mentors) with complementary expertise; (4) Formal training plans with clear milestones including trainee development of an NIH application initiated in Year 1; (5) Active research, seminars, didactic course work, workshops, and development of management, ethics, and regulatory expertise; (6) Dynamic program administration entailing monitoring with enhancements and problem resolution along with continued contact with trainees after completion and; (7) Annually convened external advisory group. Resources: Mentor funding sources include NIH Institutes, NSF, Minnesota Medical Foundation, and pharmaceutical industry. Key Personnel and Primary Mentors are directors of clinics, centers, or departments with significant resources.

摘要

项目成果

期刊论文数量（43）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Contribution of Antibody-Mediated Effector Functions to the Mechanism of Efficacy of Vaccines for Opioid Use Disorders.

DOI：
10.4049/jimmunol.2100204
发表时间：
2021-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
0
作者：
Huseby Kelcher AM;Baehr CA;Hamid FA;Hart GT;Pravetoni M
通讯作者：
Pravetoni M

Global disruption in excitation-inhibition balance can cause localized network dysfunction and Schizophrenia-like context-integration deficits.

DOI：
10.1371/journal.pcbi.1008985
发表时间：
2021-05
期刊：
PLoS computational biology
影响因子：
4.3
作者：
Calvin OL;Redish AD
通讯作者：
Redish AD

Conjoint adolescent developmental trajectories of alcohol and marijuana use and early adult outcomes among North American Indigenous people.

DOI：
10.1016/j.addbeh.2020.106758
发表时间：
2021-03
期刊：
Addictive behaviors
影响因子：
4.4
作者：
Sittner KJ;Hautala DS;Walls ML
通讯作者：
Walls ML

Using a co-twin control design to evaluate alternative trait measures as indices of liability for substance use disorders.

DOI：
10.1016/j.ijpsycho.2019.11.012
发表时间：
2020-02
期刊：
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
影响因子：
3
作者：
Joyner, Keanan J.;Yancey, James R.;Venables, Noah C.;Burwell, Scott J.;Iacono, William G.;Patrick, Christopher J.
通讯作者：
Patrick, Christopher J.

Longitudinal Mechanisms Linking Perceived Racial Discrimination to Aggressive Delinquency among North American Indigenous Youth