Multimodal characterization of affective visual processing in the early aftermath of trauma

创伤后早期情感视觉处理的多模态特征

• 批准号: 10590116
• 负责人: Nathaniel G Harnett
• 金额: $ 17.97万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590116
• 关键词: Acute; Acute Post Traumatic Stress Disorder; Affect; Affective; Architecture; Arousal; Association Learning; Attention; Behavior; Behavioral Model; Big Data; Big Data Methods; Boston; Brain; Chronic; Chronic Phase; Chronic Post Traumatic Stress Disorder; Clinical; Clinical assessments; Cognitive; Complement; Computer Models; Coupling; Data; Data Analyses; Data Collection; Development; Diffusion Magnetic Resonance Imaging; Dimensions; Discrimination; Early-life trauma; Emotional; Environment; Exposure to; Family; Functional Magnetic Resonance Imaging; Functional disorder; Future; Generations; Goals; Hospitals; Image; Imaging Techniques; Individual; Institution; Investigation; K-Series Research Career Programs; Magnetic Resonance Imaging; Maps; Mediating; Memory; Mentors; Methods; Modeling; National Institute of Mental Health; Negative Valence; Neurobiology; Neurosciences; Neurosciences Research; Pathway interactions; Perception; Population; Post-Traumatic Stress Disorders; Predisposition; Prevention; Prevention strategy; Procedures; Process; Psychiatry; Public Health; Reaction Time; Reproducibility; Research; Research Design; Research Domain Criteria; Research Personnel; Research Project Grants; Research Training; Resources; Rest; Risk; Risk Factors; Sensory; Site; Standardization; Statistical Data Interpretation; Stimulus; Stream; Symptoms; System; Training; Training Programs; Trauma; United States National Institutes of Health; Visual; Visual Pathways; Visual Perception; Visual System; Visual attention; Work; acute stress; adverse outcome; career; clinical training; clinical translation; cognitive neuroscience; cohort; conditioning; data fusion; data management; improved; individual variation; innovation; insight; large datasets; medical schools; multimodal data; multimodality; negative affect; neural; neural circuit; neurobiological mechanism; neuroimaging; neurophysiology; novel; predictive modeling; preventive intervention; programs; response; skills; social; stress reactivity; stress related disorder; stress symptom; trauma exposure; traumatic event; traumatic stress; visual processing; visual search; visual stimulus

PROJECT SUMMARY/ABSTRACT Understanding the neurobiology mediating susceptibility to trauma and stress-related disorders is necessary for future translational efforts to improve treatment and prevention. This Mentored Career Development Award proposal is tailored to facilitate the candidate’s training in multimodal assessment of brain and behavior, in addition to clinical assessment and computational psychiatry approaches, to elucidate the neurobiology of susceptibility to posttraumatic dysfunction. The proposed research training plan will build the candidate’s skills in multidimensional assessment of perceptual (i.e., visual) processing in the early aftermath of trauma, advanced computational modeling of behavioral processes, and ‘big-data’ modeling approaches for fusion of multimodal magnetic resonance imaging (MRI) data. This training is complemented by mentored training in clinical assessment of trauma-related dysfunction and research program management necessary for transition to an independent career as a translational neuroscientist. The completion of the K01 will facilitate the candidate’s transition to an independent investigator capable of developing new neuroscience-based predictive models and preventative strategies to lessen the burden of trauma and stress-related disorders. PTSD is typically conceptualized as a dysfunction of arousal and negative valence systems with the NIH Research Domain Criteria framework. However, new research demonstrates that neural circuitry of affective visual perceptual processing, in particular affective visual processing, may be a significant risk factor for PTSD. Limited work to date has probed affective visual circuitry in the early aftermath of trauma. The proposed research will leverage state-of-the-art MRI data collection and analysis with computational cognitive neuroscience approaches to elucidate impacts of trauma on affective visual processing. The project will thus better characterize an understudied aspect of the RDoC perceptual framework in trauma to integrate visual circuitry variability in both threat-related processes and PTSD-related dysfunction. Previous research in recently traumatized individuals has also not leveraged multimodal data approaches to establish generalizable markers of PTSD susceptibility. This project will address these limitations by focusing on perceptual circuits and by integrating pre-existing large datasets of trauma and PTSD with multimodal data fusion analytics to assess the robustness of observed neurobiological signatures of trauma-related dysfunction vulnerability. Further, the proposal seeks to use standardized, open processing pipelines to enhance reproducibility and replicability of observed findings to promote generalizability. The research training plan will occur at McLean Hospital, the leading psychiatric research hospital of Harvard Medical School. The institution, and academic culture in greater Boston provides an outstanding environment and access to resources for successful competition of this proposed Mentored Career Development Award.

项目摘要/摘要 了解神经生物学对创伤和应激相关疾病的易感性 这对于今后改进治疗和预防的转化工作是必要的。这个受过指导的职业生涯 发展奖建议是为促进候选人在多模式大脑评估方面的培训而量身定做的 和行为，除了临床评估和计算精神病学的方法，以阐明 创伤后功能障碍易感性的神经生物学。拟议的研究培训计划将建立 应聘者在早期对知觉(即视觉)处理的多维评估技能 创伤、行为过程的高级计算建模，以及针对 多模式磁共振成像(MRI)数据的融合。这一培训得到了指导人员的补充 创伤相关功能障碍的临床评估和研究项目管理方面的培训 过渡到独立的职业生涯，成为一名翻译神经学家。K01的落成将有助 候选人转变为能够开发基于神经科学的新预测的独立研究人员 减轻创伤和应激相关疾病负担的模型和预防策略。 创伤后应激障碍通常被概念化为NIH的觉醒和负价系统的功能障碍 研究领域标准框架。然而，新的研究表明，情感的神经回路 视觉知觉加工，特别是情感视觉加工，可能是创伤后应激障碍的重要危险因素。 到目前为止，对创伤早期情感视觉回路的研究有限。拟议的研究 将利用最先进的MRI数据收集和分析以及计算认知神经科学 阐明创伤对情感视觉加工的影响的方法。因此，这个项目将会更好 描述RDoC知觉框架在创伤中未被充分研究的一个方面，以整合视觉回路 威胁相关过程和创伤后应激障碍相关功能障碍的变异性。 以前对最近遭受创伤的个人进行的研究也没有利用多模式数据方法 建立创伤后应激障碍易感性的通用标记物。本项目将通过集中精力解决这些限制 通过将先前存在的创伤和创伤后应激障碍的大型数据集与多模式数据相结合 融合分析评估观察到的创伤相关功能障碍的神经生物学特征的稳健性 脆弱性。此外，该提案寻求使用标准化的、开放的加工管道来加强 观察结果的重现性和可复制性，以促进推广。研究培训计划将 发生在哈佛医学院领先的精神病学研究医院麦克莱恩医院。这个机构， 而大波士顿的学术文化为以下方面提供了卓越的环境和资源 这项建议的导师职业发展奖的成功竞争。