Multimodal characterization of affective visual processing in the early aftermath of trauma

创伤后早期情感视觉处理的多模态特征

• 批准号: 10590116
• 负责人: Nathaniel G Harnett
• 金额: $ 17.97万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590116
• 关键词: Acute; Acute Post Traumatic Stress Disorder; Affect; Affective; Architecture; Arousal; Association Learning; Attention; Behavior; Behavioral Model; Big Data; Big Data Methods; Boston; Brain; Chronic; Chronic Phase; Chronic Post Traumatic Stress Disorder; Clinical; Clinical assessments; Cognitive; Complement; Computer Models; Coupling; Data; Data Analyses; Data Collection; Development; Diffusion Magnetic Resonance Imaging; Dimensions; Discrimination; Early-life trauma; Emotional; Environment; Exposure to; Family; Functional Magnetic Resonance Imaging; Functional disorder; Future; Generations; Goals; Hospitals; Image; Imaging Techniques; Individual; Institution; Investigation; K-Series Research Career Programs; Magnetic Resonance Imaging; Maps; Mediating; Memory; Mentors; Methods; Modeling; National Institute of Mental Health; Negative Valence; Neurobiology; Neurosciences; Neurosciences Research; Pathway interactions; Perception; Population; Post-Traumatic Stress Disorders; Predisposition; Prevention; Prevention strategy; Procedures; Process; Psychiatry; Public Health; Reaction Time; Reproducibility; Research; Research Design; Research Domain Criteria; Research Personnel; Research Project Grants; Research Training; Resources; Rest; Risk; Risk Factors; Sensory; Site; Standardization; Statistical Data Interpretation; Stimulus; Stream; Symptoms; System; Training; Training Programs; Trauma; United States National Institutes of Health; Visual; Visual Pathways; Visual Perception; Visual System; Visual attention; Work; acute stress; adverse outcome; career; clinical training; clinical translation; cognitive neuroscience; cohort; conditioning; data fusion; data management; improved; individual variation; innovation; insight; large datasets; medical schools; multimodal data; multimodality; negative affect; neural; neural circuit; neurobiological mechanism; neuroimaging; neurophysiology; novel; predictive modeling; preventive intervention; programs; response; skills; social; stress reactivity; stress related disorder; stress symptom; trauma exposure; traumatic event; traumatic stress; visual processing; visual search; visual stimulus

PROJECT SUMMARY/ABSTRACT Understanding the neurobiology mediating susceptibility to trauma and stress-related disorders is necessary for future translational efforts to improve treatment and prevention. This Mentored Career Development Award proposal is tailored to facilitate the candidate’s training in multimodal assessment of brain and behavior, in addition to clinical assessment and computational psychiatry approaches, to elucidate the neurobiology of susceptibility to posttraumatic dysfunction. The proposed research training plan will build the candidate’s skills in multidimensional assessment of perceptual (i.e., visual) processing in the early aftermath of trauma, advanced computational modeling of behavioral processes, and ‘big-data’ modeling approaches for fusion of multimodal magnetic resonance imaging (MRI) data. This training is complemented by mentored training in clinical assessment of trauma-related dysfunction and research program management necessary for transition to an independent career as a translational neuroscientist. The completion of the K01 will facilitate the candidate’s transition to an independent investigator capable of developing new neuroscience-based predictive models and preventative strategies to lessen the burden of trauma and stress-related disorders. PTSD is typically conceptualized as a dysfunction of arousal and negative valence systems with the NIH Research Domain Criteria framework. However, new research demonstrates that neural circuitry of affective visual perceptual processing, in particular affective visual processing, may be a significant risk factor for PTSD. Limited work to date has probed affective visual circuitry in the early aftermath of trauma. The proposed research will leverage state-of-the-art MRI data collection and analysis with computational cognitive neuroscience approaches to elucidate impacts of trauma on affective visual processing. The project will thus better characterize an understudied aspect of the RDoC perceptual framework in trauma to integrate visual circuitry variability in both threat-related processes and PTSD-related dysfunction. Previous research in recently traumatized individuals has also not leveraged multimodal data approaches to establish generalizable markers of PTSD susceptibility. This project will address these limitations by focusing on perceptual circuits and by integrating pre-existing large datasets of trauma and PTSD with multimodal data fusion analytics to assess the robustness of observed neurobiological signatures of trauma-related dysfunction vulnerability. Further, the proposal seeks to use standardized, open processing pipelines to enhance reproducibility and replicability of observed findings to promote generalizability. The research training plan will occur at McLean Hospital, the leading psychiatric research hospital of Harvard Medical School. The institution, and academic culture in greater Boston provides an outstanding environment and access to resources for successful competition of this proposed Mentored Career Development Award.

项目总结/摘要 了解神经生物学介导的创伤和压力相关疾病的易感性， 对于未来改善治疗和预防的转化努力是必要的。这一指导的职业生涯 发展奖的建议是专为促进候选人的培训，在多模式评估大脑 和行为，除了临床评估和计算精神病学方法，以阐明 创伤后功能障碍易感性的神经生物学。拟议的研究培训计划将建立 候选人在感知的多维评估中的技能（即，视觉）处理的早期后果 创伤、行为过程的高级计算建模以及“大数据”建模方法 多模态磁共振成像（MRI）数据的融合。这种培训得到了指导， 创伤相关功能障碍的临床评估和研究项目管理方面的培训， 过渡到一个独立的职业生涯作为一个翻译神经科学家。K 01的完成将促进 候选人过渡到能够开发新的基于神经科学的预测的独立研究者 模式和预防战略，以减轻创伤和压力相关疾病的负担。 创伤后应激障碍通常被NIH定义为唤醒和负价系统的功能障碍 研究领域标准框架。然而，新的研究表明， 视觉感知加工，特别是情感视觉加工，可能是PTSD的重要危险因素。 迄今为止，有限的工作探讨了创伤后早期的情感视觉回路。拟议研究 将利用最先进的MRI数据收集和分析与计算认知神经科学 方法来阐明创伤对情感性视觉加工的影响。该项目将更好地 表征创伤中RDoC感知框架的未充分研究的方面，以整合视觉回路 威胁相关过程和PTSD相关功能障碍的变异性。 以前对最近遭受创伤的个人的研究也没有利用多模态数据方法 建立创伤后应激障碍易感性的普遍标记。本项目将通过关注 通过整合现有的创伤和PTSD的大型数据集与多模态数据， 融合分析，以评估观察到的创伤相关功能障碍的神经生物学特征的稳健性 易损性.此外，该提案寻求使用标准化、开放的处理管道， 观察结果的可重复性和可复制性，以促进普遍性。研究培训计划将 发生在姆克林医院，哈佛医学院领先的精神病研究医院。该机构， 和学术文化在大波士顿提供了一个优秀的环境和获得资源， 成功竞争这一拟议的指导职业发展奖。