Multimodal characterization of affective visual processing in the early aftermath of trauma
创伤后早期情感视觉处理的多模态特征
基本信息
- 批准号:10590116
- 负责人:
- 金额:$ 17.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-15 至 2026-11-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAcute Post Traumatic Stress DisorderAffectAffectiveArchitectureArousalAssociation LearningAttentionBehaviorBehavioral ModelBig DataBig Data MethodsBostonBrainChronicChronic PhaseChronic Post Traumatic Stress DisorderClinicalClinical assessmentsCognitiveComplementComputer ModelsCouplingDataData AnalysesData CollectionDevelopmentDiffusion Magnetic Resonance ImagingDimensionsDiscriminationEarly-life traumaEmotionalEnvironmentExposure toFamilyFunctional Magnetic Resonance ImagingFunctional disorderFutureGenerationsGoalsHospitalsImageImaging TechniquesIndividualInstitutionInvestigationK-Series Research Career ProgramsMagnetic Resonance ImagingMapsMediatingMemoryMentorsMethodsModelingNational Institute of Mental HealthNegative ValenceNeurobiologyNeurosciencesNeurosciences ResearchPathway interactionsPerceptionPopulationPost-Traumatic Stress DisordersPredispositionPreventionPrevention strategyProceduresProcessPsychiatryPublic HealthReaction TimeReproducibilityResearchResearch DesignResearch Domain CriteriaResearch PersonnelResearch Project GrantsResearch TrainingResourcesRestRiskRisk FactorsSensorySiteStandardizationStatistical Data InterpretationStimulusStreamSymptomsSystemTrainingTraining ProgramsTraumaUnited States National Institutes of HealthVisualVisual PathwaysVisual PerceptionVisual SystemVisual attentionWorkacute stressadverse outcomecareerclinical trainingclinical translationcognitive neurosciencecohortconditioningdata fusiondata managementimprovedindividual variationinnovationinsightlarge datasetsmedical schoolsmultimodal datamultimodalitynegative affectneuralneural circuitneurobiological mechanismneuroimagingneurophysiologynovelpredictive modelingpreventive interventionprogramsresponseskillssocialstress reactivitystress related disorderstress symptomtrauma exposuretraumatic eventtraumatic stressvisual processingvisual searchvisual stimulus
项目摘要
PROJECT SUMMARY/ABSTRACT
Understanding the neurobiology mediating susceptibility to trauma and stress-related disorders is
necessary for future translational efforts to improve treatment and prevention. This Mentored Career
Development Award proposal is tailored to facilitate the candidate’s training in multimodal assessment of brain
and behavior, in addition to clinical assessment and computational psychiatry approaches, to elucidate the
neurobiology of susceptibility to posttraumatic dysfunction. The proposed research training plan will build the
candidate’s skills in multidimensional assessment of perceptual (i.e., visual) processing in the early aftermath of
trauma, advanced computational modeling of behavioral processes, and ‘big-data’ modeling approaches for
fusion of multimodal magnetic resonance imaging (MRI) data. This training is complemented by mentored
training in clinical assessment of trauma-related dysfunction and research program management necessary for
transition to an independent career as a translational neuroscientist. The completion of the K01 will facilitate the
candidate’s transition to an independent investigator capable of developing new neuroscience-based predictive
models and preventative strategies to lessen the burden of trauma and stress-related disorders.
PTSD is typically conceptualized as a dysfunction of arousal and negative valence systems with the NIH
Research Domain Criteria framework. However, new research demonstrates that neural circuitry of affective
visual perceptual processing, in particular affective visual processing, may be a significant risk factor for PTSD.
Limited work to date has probed affective visual circuitry in the early aftermath of trauma. The proposed research
will leverage state-of-the-art MRI data collection and analysis with computational cognitive neuroscience
approaches to elucidate impacts of trauma on affective visual processing. The project will thus better
characterize an understudied aspect of the RDoC perceptual framework in trauma to integrate visual circuitry
variability in both threat-related processes and PTSD-related dysfunction.
Previous research in recently traumatized individuals has also not leveraged multimodal data approaches
to establish generalizable markers of PTSD susceptibility. This project will address these limitations by focusing
on perceptual circuits and by integrating pre-existing large datasets of trauma and PTSD with multimodal data
fusion analytics to assess the robustness of observed neurobiological signatures of trauma-related dysfunction
vulnerability. Further, the proposal seeks to use standardized, open processing pipelines to enhance
reproducibility and replicability of observed findings to promote generalizability. The research training plan will
occur at McLean Hospital, the leading psychiatric research hospital of Harvard Medical School. The institution,
and academic culture in greater Boston provides an outstanding environment and access to resources for
successful competition of this proposed Mentored Career Development Award.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nathaniel G Harnett其他文献
Nathaniel G Harnett的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nathaniel G Harnett', 18)}}的其他基金
A Multidimensional Neuroimaging Investigation of Posttraumatic Stress in Humans
人类创伤后应激的多维神经影像研究
- 批准号:
10221466 - 财政年份:2018
- 资助金额:
$ 17.97万 - 项目类别:
A Multidimensional Neuroimaging Investigation of Posttraumatic Stress in Humans
人类创伤后应激的多维神经影像研究
- 批准号:
10012946 - 财政年份:2018
- 资助金额:
$ 17.97万 - 项目类别:
A Multidimensional Neuroimaging Investigation of Posttraumatic Stress in Humans
人类创伤后应激的多维神经影像研究
- 批准号:
9467954 - 财政年份:2017
- 资助金额:
$ 17.97万 - 项目类别:














{{item.name}}会员




