A Multidimensional Neuroimaging Investigation of Posttraumatic Stress in Humans

人类创伤后应激的多维神经影像研究

• 批准号: 9467954
• 负责人: Nathaniel G Harnett
• 金额: $ 3.86万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-28 至 2018-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9467954
• 关键词: Acute; Address; Area; Award; Behavioral; Biochemical; Biochemistry; Brain; Clinical Research; Collaborations; Competence; Data Collection; Development; Diagnostic Specificity; Distress; Drops; Educational process of instructing; Emotional; Ensure; Faculty; Functional Magnetic Resonance Imaging; Goals; Human; Individual; Individual Differences; Institutes; Investigation; Manuscripts; Mediating; Mentors; Mentorship; Methods; Neurobiology; Neurology; Neurosciences Research; Phase; Post-Traumatic Stress Disorders; Predisposition; Prevention; Privatization; Procedures; Program Development; Psychiatry; Psychology; Public Health; Publications; Research; Research Personnel; Research Project Grants; Research Training; Self Efficacy; Severities; Stress; Structure; Students; Techniques; Technology; Training; Training Support; Translating; Trauma; Treatment outcome; Underrepresented Minority; United States; United States National Institutes of Health; Work; Writing; conditioned fear; effective intervention; experience; improved; innovation; insight; intervention program; member; multimodality; neuroimaging; neuroregulation; novel; post-doctoral training; post-traumatic stress; pre-doctoral; programs; skills; statistics; stress disorder; tractography; traumatic event; treatment program; underrepresented minority student; white matter

PROJECT SUMMARY/ABSTRACT Neuroscientists from underrepresents backgrounds drop out of predoctoral programs at a significantly higher rate than traditional students. This attrition has a detrimental impact on the scientific field as decreases in diversity diminish the range of techniques, perspectives, and potential for innovative collaborations necessary for scientific discovery. Therefore, the objective of the current proposal is to institute a robust individual research training plan to increase the diversity of the neuroscientific workforce. Specifically, a structured and formal training plan will supplement the applicant’s intensive dissertation research on the neurobiology of post-traumatic stress. Each year 25 million people in the United States suffer a traumatic event, however only about 30% of these individuals develop Post-Traumatic Stress Disorder (PTSD). Thus, there is individual variability in stress susceptibility, which may be due to variability in the neurobiology of post- traumatic stress. Currently, the acute effect (i.e. within a month) of post-traumatic stress on the brain is not well understood. Determining the impact of trauma-induced distress on brain structure, function, and biochemistry is critical for a thorough understanding of stress disorder that can then be translated into effective intervention and treatment programs. The applicant’s research during the F99 phase will utilize human neuroimaging technology with healthy and traumatized individuals to investigate how brain function, structure, and biochemistry vary with post-traumatic stress severity. The proposed research project will be completed in conjunction with a formal training plan. Specifically, training during the F99 phase will focus on developing competency in 1) MR methods/techniques, 2) scientific writing/presentation, and 3) mentorship skills. The applicant’s mentorship team includes established faculty members to provide formal training in these areas, as well as direct mentorship regarding particularly sensitive issues (e.g., self-efficacy, navigating professional interactions, etc.) for underrepresented minority scholars. The mentorship team is scientifically diverse drawing from faculty within the Departments of Psychology (Dr. David C. Knight – Primary Mentor), Neurology (Dr. Jerzy Szaflarski), Psychiatry and Behavioral Neurobiology (Dr. Adrienne Lahti), and Neurobiology (Dr. Farah Lubin). As part of the K00 phase, the applicant intends to translate the findings from the F99 phase into clinical research using novel neuroimaging and neuromodulatory techniques. The research direction is intended to focus on 1) prediction of stress disorder following trauma via advanced/integrated neuroimaging techniques and 2) prevention of stress disorder development through neuromodulatory techniques. Training during the K00 phase will focus on developing competency in 1) novel research approaches, 2) research program development and management, and 3) teaching skills. The current application will guide the applicant through the academic pipeline and allow him to achieve his goal of becoming an independent neuroscientist.

项目总结/摘要 来自代表性不足背景的神经科学家在一个显着的时间内退出了博士前课程 比传统的学生高。这种流失对科学领域产生了不利影响， 在多样性中，减少了技术、观点和创新合作潜力的范围 科学发现所必需的。因此，本提案的目标是建立一个强有力的 个人研究培训计划，以增加神经科学工作人员的多样性。特别是 结构化和正式的培训计划将补充申请人的密集论文研究， 创伤后压力的神经生物学美国每年有2500万人遭受创伤， 然而，只有大约30%的人发展为创伤后应激障碍（PTSD）。因此，在本发明中， 在压力敏感性方面存在个体差异，这可能是由于术后神经生物学的差异。 创伤压力目前，创伤后应激对大脑的急性影响（即在一个月内）并不好 明白确定创伤引起的痛苦对大脑结构、功能和生物化学的影响 对于彻底了解应激障碍至关重要，然后可以转化为有效的干预措施 和治疗方案。申请人在F99阶段的研究将利用人类神经成像 技术与健康和创伤的个人，以调查如何大脑功能，结构， 生化反应随创伤后应激反应的严重程度而变化。建议的研究项目将于二零零零年完成。 结合正式的培训计划。具体来说，F99阶段的培训将重点关注开发 在1）MR方法/技术，2）科学写作/演示和3）指导技能方面的能力。的 申请人的导师团队包括既定的教师，以提供这些领域的正式培训， 以及就特别敏感的问题提供直接指导（例如，自我效能感，航海专业 互动等）少数民族学者的机会导师团队是科学多样的绘图 来自心理学系的教员（大卫C。骑士-主要导师），神经病学（博士。 Jerzy Szaflarski）、精神病学和行为神经生物学（Adrienne拉赫蒂博士）和神经生物学（法拉博士 Lubin）。作为K 00阶段的一部分，申请人计划将F99阶段的结果转化为临床研究结果。 使用新的神经成像和神经调节技术进行研究。该研究方向旨在 专注于1）通过先进/综合神经影像技术预测创伤后应激障碍 和2）通过神经调节技术预防应激障碍的发展。培训期间， K 00阶段将侧重于发展1）新的研究方法，2）研究计划的能力 开发与管理; 3）教学技能。当前的应用程序将引导申请人通过 学术管道，并使他能够实现成为一名独立神经科学家的目标。