Neuropathology Core

神经病理学核心

• 批准号: 10590704
• 负责人: Julia K Kofler
• 金额: $ 49.5万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590704
• 关键词: Access to Information; Aging; Algorithms; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Area; Autopsy; Biological Markers; Brain; Classification; Clinical; Cognitive; Collaborations; Communities; Consensus; Data; Databases; Detection; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Evaluation; Family; Feedback; Fibroblasts; Frontotemporal Lobar Degenerations; Genetic; Genetic Polymorphism; Harvest; Image; Image Analysis; Imaging technology; Joints; Knowledge; Laboratories; Liquid substance; MRI Scans; Measures; Medical Students; Mentors; Microscopy; Mission; Molecular; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Participant; Pathologic; Pathology; Phenotype; Positron-Emission Tomography; Process; Protocols documentation; Psychoses; Recommendation; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Role; Scanning; Secure; Slice; Systems Analysis; Technical Expertise; Technology; Time; Tissue Banks; Tissue Sample; Tissues; Triage; United States National Institutes of Health; Universities; Update; Variant; Vascular Diseases; alpha synuclein; amyloid imaging; brain tissue; clinical diagnosis; clinical phenotype; cohort; comorbidity; computational pipelines; data management; data sharing; diagnostic criteria; digital; digital imaging; education research; endophenotype; histological image; human tissue; imaging agent; imaging approach; imaging biomarker; imaging study; improved; in vivo; instrumentation; interest; mild cognitive impairment; neuroimaging; neuroinflammation; neuropathology; novel; personalized diagnostics; protein TDP-43; psychiatric comorbidity; repository; research study; resilience; skills; statistics; tau Proteins; therapeutic target; tool; treatment response; web app; whole slide imaging

Core D: Neuropathology Core. Summary/Abstract: The Neuropathology (NP) Core fulfills several important roles within the University of Pittsburgh ADRC (PITT-ADRC). Postmortem neuropathological confirmation of the clinical diagnosis of Alzheimer’s disease (AD) and related disorders and the assessment of co-existing neurodegenerative and vascular disease processes is essential to promote progress in diagnosis, treatment and prevention of AD. Since its inception, the NP Core has collected and characterized >739 brains from PITT-ADRC subjects at various disease stages. This resource has been extensively utilized for teaching purposes and for research studies by local and national investigators to develop amyloid PET imaging agents and correlate in vivo amyloid imaging results with postmortem findings, improve our understanding of genetic factors contributing to AD risk and advance our knowledge regarding the neurobiology of psychiatric comorbidities and neuroinflammatory processes. Our proposed approach to fulfill the diagnostic, tissue banking, research and educational roles of the NP Core is outlined in five specific aims: 1) The NP Core will continue to maintain and expand a well-catalogued bank of brain tissue samples and fibroblasts of ADRC participants and subjects from affiliated cohorts. A special emphasis will be placed on harvesting brains from subjects with premortem PiB and tau PET imaging studies. 2) All banked cases will undergo detailed diagnostic evaluation using the latest consensus criteria and detailed characterization of comorbid and aging-related pathologies. Results will be shared with ADRC clinical staff, families and uploaded to local and national databases (NACC). 3) The NP Core will provide neuropathological skills and expertise to researchers and will expand its efforts to utilize digital microscopy technologies and image analysis tools for identification and quantification of neurodegenerative pathologies. The generated pathology endophenotypes will be made available for association studies with genetic polymorphisms and clinical phenotypes such as the presence of psychiatric comorbidities, a major area of research at the PITT-ADRC. 4) The NP Core will continue to participate in local and national research efforts by providing brain bank tissue materials and neuropathology data from diagnostic evaluations. The NP core will closely collaborate with other PITT-ADRC cores and projects in joint research studies and will engage in NP Core-driven research projects. 5) In collaboration with the Research Education Component, the NP core will leverage brain bank materials and expertise to educate neuropathology fellows, residents, medical students and investigators about the neuropathologic features of neurodegenerative diseases. Through these aims, the NP core will provide precise diagnostic classifications of ADRC research participants, enable studies of phenotype variations and broadly support efforts to improve our understanding of the underlying disease processes.

核心D：神经病理学核心。摘要/摘要： 神经病理学(NP)的核心实现了几个 在匹兹堡大学ADRC(匹兹堡-ADRC)内担任重要角色。死后神经病理学 确认阿尔茨海默病(AD)及相关疾病的临床诊断和评估 共存的神经退行性疾病和血管疾病过程对于促进诊断的进步是必不可少的， 治疗和预防阿尔茨海默病。自成立以来，NP Core已经收集并表征了&gt；739个大脑 来自不同疾病阶段的PITT-ADRC受试者。这一资源已被广泛用于教学 目的以及地方和国家研究人员开发淀粉样蛋白PET显像剂的研究 并将体内淀粉样蛋白成像结果与尸检结果相关联，提高我们对基因的理解 AD风险的因素和提高我们对精神疾病的神经生物学的认识 合并症和神经炎性过程。 我们建议的方法来履行NP的诊断、组织银行、研究和教育角色 核心在五个具体目标中概述：1)国家警察核心将继续维持和扩大编目良好的 ADRC参与者和附属队列受试者的脑组织样本库和成纤维细胞库。一个 将特别强调从死前进行PIB和tau PET成像的受试者中获取大脑 学习。2)所有储存的病例将使用最新的共识标准进行详细的诊断评估，并 合并症和衰老相关病理的详细特征。结果将与ADRC临床共享 工作人员、家属，并上传到地方和国家数据库(NACC)。3)NP核心将提供 为研究人员提供神经病理学技能和专业知识，并将扩大其利用数字显微镜的努力 识别和量化神经退行性病变的技术和图像分析工具。 所产生的病理内表型将用于与遗传相关的研究 多态和临床表型，如精神合并症的存在，一个主要的领域 皮特-ADRC的研究。4)NP核心将继续参与地方和国家的研究工作 通过提供来自诊断评估的脑库组织材料和神经病理学数据。NP核心 将在联合研究研究方面与PIT-ADRC的其他核心和项目密切合作，并将参与 NP核心驱动的研究项目。5)与研究教育部门、国家方案核心部门合作 将利用脑库材料和专业知识来教育神经病理研究员、住院医生、医疗人员 学生和研究人员了解神经退行性疾病的神经病理特征。 通过这些目标，NP核心将为ADRC研究提供精确的诊断分类 参与者，使表型变异的研究成为可能，并广泛支持提高我们理解的努力 潜在的疾病过程。