Neuropathology Core

神经病理学核心

• 批准号: 10590704
• 负责人: Julia K Kofler
• 金额: $ 49.5万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590704
• 关键词: Access to Information; Aging; Algorithms; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Area; Autopsy; Biological Markers; Brain; Classification; Clinical; Cognitive; Collaborations; Communities; Consensus; Data; Databases; Detection; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Evaluation; Family; Feedback; Fibroblasts; Frontotemporal Lobar Degenerations; Genetic; Genetic Polymorphism; Harvest; Image; Image Analysis; Imaging technology; Joints; Knowledge; Laboratories; Liquid substance; MRI Scans; Measures; Medical Students; Mentors; Microscopy; Mission; Molecular; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Participant; Pathologic; Pathology; Phenotype; Positron-Emission Tomography; Process; Protocols documentation; Psychoses; Recommendation; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Role; Scanning; Secure; Slice; Systems Analysis; Technical Expertise; Technology; Time; Tissue Banks; Tissue Sample; Tissues; Triage; United States National Institutes of Health; Universities; Update; Variant; Vascular Diseases; alpha synuclein; amyloid imaging; brain tissue; clinical diagnosis; clinical phenotype; cohort; comorbidity; computational pipelines; data management; data sharing; diagnostic criteria; digital; digital imaging; education research; endophenotype; histological image; human tissue; imaging agent; imaging approach; imaging biomarker; imaging study; improved; in vivo; instrumentation; interest; mild cognitive impairment; neuroimaging; neuroinflammation; neuropathology; novel; personalized diagnostics; protein TDP-43; psychiatric comorbidity; repository; research study; resilience; skills; statistics; tau Proteins; therapeutic target; tool; treatment response; web app; whole slide imaging

Core D: Neuropathology Core. Summary/Abstract: The Neuropathology (NP) Core fulfills several important roles within the University of Pittsburgh ADRC (PITT-ADRC). Postmortem neuropathological confirmation of the clinical diagnosis of Alzheimer’s disease (AD) and related disorders and the assessment of co-existing neurodegenerative and vascular disease processes is essential to promote progress in diagnosis, treatment and prevention of AD. Since its inception, the NP Core has collected and characterized >739 brains from PITT-ADRC subjects at various disease stages. This resource has been extensively utilized for teaching purposes and for research studies by local and national investigators to develop amyloid PET imaging agents and correlate in vivo amyloid imaging results with postmortem findings, improve our understanding of genetic factors contributing to AD risk and advance our knowledge regarding the neurobiology of psychiatric comorbidities and neuroinflammatory processes. Our proposed approach to fulfill the diagnostic, tissue banking, research and educational roles of the NP Core is outlined in five specific aims: 1) The NP Core will continue to maintain and expand a well-catalogued bank of brain tissue samples and fibroblasts of ADRC participants and subjects from affiliated cohorts. A special emphasis will be placed on harvesting brains from subjects with premortem PiB and tau PET imaging studies. 2) All banked cases will undergo detailed diagnostic evaluation using the latest consensus criteria and detailed characterization of comorbid and aging-related pathologies. Results will be shared with ADRC clinical staff, families and uploaded to local and national databases (NACC). 3) The NP Core will provide neuropathological skills and expertise to researchers and will expand its efforts to utilize digital microscopy technologies and image analysis tools for identification and quantification of neurodegenerative pathologies. The generated pathology endophenotypes will be made available for association studies with genetic polymorphisms and clinical phenotypes such as the presence of psychiatric comorbidities, a major area of research at the PITT-ADRC. 4) The NP Core will continue to participate in local and national research efforts by providing brain bank tissue materials and neuropathology data from diagnostic evaluations. The NP core will closely collaborate with other PITT-ADRC cores and projects in joint research studies and will engage in NP Core-driven research projects. 5) In collaboration with the Research Education Component, the NP core will leverage brain bank materials and expertise to educate neuropathology fellows, residents, medical students and investigators about the neuropathologic features of neurodegenerative diseases. Through these aims, the NP core will provide precise diagnostic classifications of ADRC research participants, enable studies of phenotype variations and broadly support efforts to improve our understanding of the underlying disease processes.

核心D：神经病理学核心。总结/摘要： 神经病理学（NP）核心实现了几个 匹兹堡大学ADRC（PITT-ADRC）。死后神经病理学 阿尔茨海默病（AD）和相关病症的临床诊断的确认和 共存的神经变性和血管疾病过程对于促进诊断进展是必不可少的， AD的治疗和预防。自成立以来，NP Core已经收集和表征了超过739个大脑 来自不同疾病阶段的PITT-ADRC受试者。这一资源已被广泛用于教学 目的，并由当地和国家研究者进行研究，以开发淀粉样蛋白PET成像剂 并将体内淀粉样蛋白成像结果与死后发现相关联， 有助于AD风险的因素，并推进我们对精神疾病神经生物学的认识。 合并症和神经炎症过程。 我们提出的方法，以履行诊断，组织库，研究和教育的作用，核武器 核心概述了五个具体目标：1）NP核心将继续保持和扩大一个良好的编目 ADRC参与者和附属队列受试者的脑组织样本和成纤维细胞库。一 特别强调的是，从受试者中采集大脑，进行死前PiB和tau PET成像 问题研究2)所有库存病例将使用最新的共识标准进行详细的诊断评估， 共病和衰老相关病理的详细表征。结果将与ADRC临床共享 工作人员、家属和上传到地方和国家数据库（NACC）。3)NP Core将提供 神经病理学技能和专业知识的研究人员，并将扩大其努力，利用数字显微镜 用于识别和量化神经退行性病变的技术和图像分析工具。 所生成的病理学内表型将可用于与遗传相关性研究。 多态性和临床表型，如精神共病的存在，一个主要的领域， PITT-ADRC的研究。4)NP核心将继续参与地方和国家的研究工作 通过提供脑库组织材料和来自诊断评估的神经病理学数据。NP核心 将与其他PITT-ADRC核心和项目密切合作，进行联合研究，并将参与 NP核心驱动的研究项目。5)与研究教育组成部分合作，NP核心 将利用脑库的材料和专业知识，教育神经病理学研究员，居民，医疗 学生和研究人员关于神经退行性疾病的神经病理学特征。 通过这些目标，NP核心将提供ADRC研究的精确诊断分类 参与者，使表型变异的研究和广泛支持的努力，以提高我们的理解 潜在的疾病过程。