Mentored Patient-Oriented Research for Preventing ASCVD Events

项目摘要/摘要莫拉博士是一位接受过流行病学交叉培训的心脏病专家，她的职业生涯致力于心血管疾病预防中以患者为导向的研究（POR），专注于心脏代谢疾病风险的脂质生物标志物的发现和转化应用，并开发预防心脏代谢疾病的创新方法和疗法。她的POR研究影响了国家和国际临床实践指南，在第一个K24周期，她指导了超过15名与脂质，他汀类药物和心血管风险相关的POR项目的博士前和博士后学员。近年来，她的学员在国内和国际上展示其工作所取得的成就凸显了这一点，K24更新奖将使她能够扩展她成功的辅导计划。该K24奖项的总体目标是：1）通过将高通量代谢组学的技术进步与临床和健康记录数据相结合，为下一代心血管研究人员提供预防精确POR的机会，从而发展和扩大她的POR计划，作为改善心血管结局的策略; 2）通过扩大POR项目来检查导致过早心血管事件的心脏代谢风险因素，从而加强和建立她在全球心血管健康方面的指导计划。心血管疾病仍然是全球头号死亡原因，超过70%的病例可归因于心脏代谢风险因素。具有不受控制的心脏代谢风险因素的患者具有患早发性和复发性心血管事件的高风险。候选人正在进行的POR项目，卓越的机构资源，以及具有成本效益的本地和国际合作，为POR心血管研究的初级研究人员的培训和职业发展提供了良好的环境。该奖项提出的新研究目标将研究一组具有不同患者人群心血管疾病风险的靶向代谢组学，以更好地了解如何将心脏代谢风险因素作为精确预防诊断和治疗目标。该研究计划将为初级研究人员和学员提供极好的POR机会，以便在临床，流行病学和分子研究的全方位进行指导。这项指导性POR计划的结果将指导未来针对心血管筛查、风险分层和可能更有针对性的精准医学干预措施的努力，以改善心血管健康。为此，这个K24奖项将促进莫拉博士的学员成为下一代以患者为导向的独立心血管研究人员。

Project Summary/Abstract Dr, Mora is a cardiologist cross-trained in epidemiology who has devoted her career to patient-oriented research (POR) in cardiovascular prevention, focusing on the discovery and translational applications of lipid biomarkers of cardiometabolic disease risk, and developing innovative approaches and therapies for preventing cardiometabolic disease. Her POR research has impacted national and international guidelines for clinical practice, In the first K24 cycle, she has mentored more than fifteen preand postdoctoral trainees in POR projects related to lipids, statins, and cardiovascular risk. This has been highlighted in recent years by the achievements of her mentees in presenting their work nationally and internationally, The K24 renewal award will allow her to extend her successful mentoring program. The overall goals of this K24 award are to 1) grow and expand her POR program by providing the next-generation of cardiovascular investigators with opportunities for precision POR in prevention by incorporating technologic advances in high-throughput metabolomics with clinical and health record data as a strategy to improve cardiovascular outcomes; and 2) strengthen and build upon her mentoring program in global cardiovascular health by expanding her POR program to examine cardiometabolic risk factors contributing to premature cardiovascular events. Cardiovascular disease remains the number one cause of death globally, and > 70% of cases can be attributed to cardiometabolic risk factors. Patients with uncontrolled cardiometabolic risk factors are at high risk of suffering from premature and recurrent cardiovascular events. The candidate's ongoing POR projects, exceptional institutional resources, and cost-effective local and international collaborations provide a nurturing environment for the training and career development of junior investigators in POR cardiovascular research. The new research aims proposed in this award will examine a panel of targeted metabolomics with risk of cardiovascular disease from diverse patient populations to better understand how cardiometabolic risk factors could be targeted for precision preventative diagnostic and therapeutic targets. This research program will provide excellent POR opportunities for junior investigators and trainees to be mentored across the full spectrum of clinical, epidemiological, and molecular studies. Results from this mentored POR program will guide future efforts directed at cardiovascular screening, risk stratification, and potentially more targeted precision medicine interventions to improve cardiovascular health. Towards that end, this K24 award will facilitate the progress of Dr, Mora's mentees into the next generation of patient-oriented independent cardiovascular researchers.