Developmental Core

发展核心

• 批准号: 10598775
• 负责人: John T West
• 金额: $ 7.1万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598775
• 关键词: AIDS related cancer; Academic Training; Address; Affect; Africa; Africa South of the Sahara; African; Area; Authorship; Autopsy; Basic Science; Bioinformatics; Biological Markers; Biomedical Research; Biometry; Cancer Center; Cancer Research Infrastructure; Caring; Clinical; Clinical Medicine; Clinical Sciences; Collaborations; Communicable Diseases; Country; Coupled; Database Management Systems; Databases; Development; Diagnosis; Diagnostic; Disease; Educational workshop; Etiology; Faculty; Fostering; Funding; Genetic; Goals; HIV; HIV-1; HIV/AIDS; Health; Health Sciences; Histopathology; Hospitals; Human Herpesvirus 8; Human Resources; Immunologics; Immunology; Incentives; Incidence; Institution; Internet; Kaposi Sarcoma; Louisiana; Malignant Neoplasms; Medical; Mentors; National Institute of General Medical Sciences; Oceans; Oncology; Outcome; Persons; Pilot Projects; Prevention; Productivity; Program Development; Program Research Project Grants; Public Health; Public Health Schools; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Tanzania; Targeted Research; Teaching Hospitals; Tissues; Training; Training Activity; Training Programs; United States; Universities; Viral; Viral reservoir; Virus Latency; Zambia; anticancer research; antiretroviral therapy; career; career development; comparative; design; experience; global health; implementation science; improved; inter-institutional; interest; leadership development; low and middle-income countries; metabolomics; neoplastic; next generation; peer; peer coaching; peer networks; programs; radiological imaging; research and development; skill acquisition; skills; success; training opportunity; virus related cancer

ABSTRACT Human resource capacity building and training are urgently needed to establish a sustainable research enterprise that will improve prevention, diagnosis, connection to care, basic mechanistic understanding, and treatment of neoplastic diseases, like Kaposi sarcoma (KS) that continue to affect people living with HIV (PLWH), despite effective antiretroviral therapy (ART). The combined expertise of our team, coupled with our ongoing D43 cancer research and training programs with CDH/UTH and ORCI, will bolster the continued development of CDH/UTH and ORCI research on KS and other HIV associated malignancies, while promoting inter-African research networking. It will also provide opportunities for U.S. oncology, infectious disease, and public health fellows interested in a research career in global health to gain essential experience in the LMIC setting and develop research collaborations. To further enhance cancer research infrastructure in Tanzania and Zambia, and specifically focus on KS, the “KS in the Era of ART in Africa Program (KEAAP)” proposes to establish a network comprised of LSUHSC-NO, CDH/UTH, and ORCI that is focused on implementation science, immunology, and histopathology of KS in PLWH. The goal of the Career Developmental Core is to provide mentoring and training activities that will support the research, career, and leadership development of promising investigators at ORCI and CDH/UTH as well as early-career clinical researchers from the United States. This goal will be achieved by 1) implementing a mentored pilot research project program to support scientifically meritorious projects led by junior investigators in Tanzania, Zambia, and the United States; 2) expanding peer-to-peer mentoring and career development programs between CDH/UTH, ORCI, and LSUHSC-NO; and 3) providing in-country courses, workshops, and cross-training between UTH and ORCI, focused on targeted research skills and professional development needs of early-stage investigators. Through these research and capacity building activities, KEAAP will foster an integrated mentoring approach, utilizing faculty from all involved institutions to serve as a resource for consortium trainees. KEAAP will encourage peer-peer networking among researchers through in-person and web-hosted training. KEAAP will develop a next-generation of researchers, mentors, and trainers who are anticipated to collaborate in, develop and cross- pollinate other’s research and training efforts that promote the development of increasingly more effective research networks for Sub-Saharan Africa/US collaborations focused on improving health outcomes for PLWH.

摘要 迫切需要人力资源能力建设和培训，以建立可持续的研究 企业，将改善预防，诊断，连接到护理，基本机制的理解， 治疗肿瘤性疾病，如卡波西肉瘤（KS），继续影响艾滋病毒感染者 （PLWH），尽管有效的抗逆转录病毒治疗（ART）。我们团队的综合专业知识，加上我们的 正在进行的D43癌症研究和培训计划与CDH/UTH和ORCI，将支持继续 发展CDH/UTH和ORCI对KS和其他HIV相关恶性肿瘤的研究，同时促进 非洲研究网络。它还将为美国的肿瘤学、传染病和 对全球卫生研究事业感兴趣的公共卫生研究员，以获得LMIC的基本经验 建立和发展研究合作。进一步加强坦桑尼亚的癌症研究基础设施 非洲抗逆转录病毒疗法时代的知识共享计划（KEAAP）提出， 建立一个由LSUHSC-NO、CDH/UTH和ORCI组成的网络，重点是实施 PLWH中KS的科学、免疫学和组织病理学。职业发展核心的目标是 提供指导和培训活动，以支持研究，职业生涯和领导力发展， ORCI和CDH/UTH的有前途的研究人员以及来自美国的早期职业临床研究人员 States.这一目标将通过以下方式实现：1）实施一项指导性试点研究项目计划， 由坦桑尼亚、赞比亚和美国的初级研究人员领导的科学上有价值的项目; 2） 扩大CDH/UTH、ORCI和 LSUHSC-NO;以及3）提供国内课程、讲习班和UTH与ORCI之间的交叉培训， 侧重于有针对性的研究技能和早期研究人员的专业发展需求。通过 这些研究和能力建设活动，KEAAP将促进综合辅导方法，利用 所有有关机构的教员作为联合会学员的资源。KEAAP将鼓励 通过面对面培训和网络托管培训，在研究人员之间建立同行网络。KEAAP将开发一个 下一代的研究人员，导师和培训师谁预计将合作，发展和交叉， 传播他人的研究和培训努力，促进日益有效的发展 撒哈拉以南非洲/美国合作的研究网络侧重于改善艾滋病毒携带者的健康结果。