Developmental Core

摘要 迫切需要人力资源能力建设和培训，以建立可持续的研究 企业将改善预防、诊断、与护理的连接、基本机制理解，以及 治疗继续影响艾滋病毒携带者的肿瘤疾病，如卡波西肉瘤(KS) (PLWH)，尽管有效的抗逆转录病毒治疗(ART)。我们团队的专业知识，加上我们的 正在进行的D43癌症研究和与CDH/UTH和ORCI的培训计划将支持继续 CDH/UTH和ORCI对KS和其他艾滋病毒相关恶性肿瘤的研究进展，同时促进 非洲间研究网络。它还将为美国肿瘤学、传染病和 对全球卫生研究事业感兴趣的公共卫生研究员，以获得LMIC的基本经验 建立和发展研究合作。进一步加强坦桑尼亚的癌症研究基础设施 和赞比亚，并特别关注KS，“非洲艺术时代的KS方案(KEAAP)”建议 建立由LSUHSC-NO、CDH/UTH和ORCI组成的专注于实施的网络 PLWH中KS的科学、免疫学和组织病理学。职业发展核心的目标是 提供指导和培训活动，支持以下领域的研究、职业生涯和领导力发展 Orci和CDH/UTH的有前途的研究人员以及来自美国的职业生涯早期临床研究人员 各州。这一目标将通过1)实施有指导的试点研究项目计划来实现，以支持 由坦桑尼亚、赞比亚和美国的初级调查人员领导的具有科学价值的项目；2) 扩展CDH/UTH、ORCI和CDH/UTH、ORCI和 LSUHSC-NO；以及3)提供国内课程、讲习班，以及UTH和ORCI之间的交叉培训， 重点关注早期调查人员的有针对性的研究技能和专业发展需求。穿过 这些研究和能力建设活动，KEAAP将促进一种综合的指导方法，利用 来自所有相关机构的教师作为财团学员的资源。KEAAP将鼓励 通过面对面和网络托管的培训，在研究人员之间建立对等网络。KEAAP将开发一种 下一代研究人员、导师和培训师，他们有望在以下方面进行合作、开发和交叉 授粉他人的研究和培训努力，促进发展日益有效 撒哈拉以南非洲/美国合作研究网络的重点是改善公共卫生部门的健康结果。

ABSTRACT Human resource capacity building and training are urgently needed to establish a sustainable research enterprise that will improve prevention, diagnosis, connection to care, basic mechanistic understanding, and treatment of neoplastic diseases, like Kaposi sarcoma (KS) that continue to affect people living with HIV (PLWH), despite effective antiretroviral therapy (ART). The combined expertise of our team, coupled with our ongoing D43 cancer research and training programs with CDH/UTH and ORCI, will bolster the continued development of CDH/UTH and ORCI research on KS and other HIV associated malignancies, while promoting inter-African research networking. It will also provide opportunities for U.S. oncology, infectious disease, and public health fellows interested in a research career in global health to gain essential experience in the LMIC setting and develop research collaborations. To further enhance cancer research infrastructure in Tanzania and Zambia, and specifically focus on KS, the “KS in the Era of ART in Africa Program (KEAAP)” proposes to establish a network comprised of LSUHSC-NO, CDH/UTH, and ORCI that is focused on implementation science, immunology, and histopathology of KS in PLWH. The goal of the Career Developmental Core is to provide mentoring and training activities that will support the research, career, and leadership development of promising investigators at ORCI and CDH/UTH as well as early-career clinical researchers from the United States. This goal will be achieved by 1) implementing a mentored pilot research project program to support scientifically meritorious projects led by junior investigators in Tanzania, Zambia, and the United States; 2) expanding peer-to-peer mentoring and career development programs between CDH/UTH, ORCI, and LSUHSC-NO; and 3) providing in-country courses, workshops, and cross-training between UTH and ORCI, focused on targeted research skills and professional development needs of early-stage investigators. Through these research and capacity building activities, KEAAP will foster an integrated mentoring approach, utilizing faculty from all involved institutions to serve as a resource for consortium trainees. KEAAP will encourage peer-peer networking among researchers through in-person and web-hosted training. KEAAP will develop a next-generation of researchers, mentors, and trainers who are anticipated to collaborate in, develop and cross- pollinate other’s research and training efforts that promote the development of increasingly more effective research networks for Sub-Saharan Africa/US collaborations focused on improving health outcomes for PLWH.