权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute Stroke

用于急性中风的便携式低场脑部磁共振成像 (MRI)

基本信息

批准号：
10599258
负责人：
William Taylor Kimberly
金额：
$ 70.43万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599258
关键词：
Acute Algorithms Ambulances Blood Brain Edema Brain Injuries Brain hemorrhage Cerebral hemisphere hemorrhage Cessation of life Characteristics Classification Clinical Clinical Research Collaborations Communities Computed Tomography Scanners Computer Interface Controlled Environment Critical Illness Data Data Set Decision Making Democracy Detection Development Diagnosis Diagnostic Diffusion Emergency Medicine Engineering Enrollment Environment General Hospitals Health Health system Hemorrhage Hospitals Hour Human Image Image Analysis Industry Collaboration Infarction Institution Ischemia Ischemic Stroke Liquid substance Machine Learning Magnetic Resonance Imaging Massachusetts Measurement Measures Methodology Methods Modeling Monitor Multicenter Studies Neurologic Patient Care Patients Physiologic pulse Positioning Attribute Power Sources Public Health Radiation Research Resolution Resources Rural Community Sampling Scanning Sensitivity and Specificity Serial Magnetic Resonance Imaging Source Specialist Specificity Stroke System Tablet Computer Techniques Technology Time Training Translational Research Uncertainty Weight X-Ray Computed Tomography acute stroke brain magnetic resonance imaging classification algorithm clinical care clinical translation cost cryogenics deep learning deep neural network design diagnostic accuracy diagnostic technologies disability experience health care settings image reconstruction improved individual patient industry partner innovation insight instrument instrumentation low and middle-income countries magnetic field multidisciplinary neuroimaging novel novel strategies operation point of care portability post stroke prevent prospective reconstruction standard of care stroke neurology stroke patient success technological innovation tool ultra high resolution virtual

项目摘要

Abstract Neuroimaging is a cornerstone of patient care for patients with brain injury. High field magnets and access to imaging interpretation have prevented magnetic resonance imaging (MRI) from becoming a universally available tool. Our group has demonstrated the feasibility of acquiring clinically useful images on a portable, low-field MRI. In this proposal, we will validate the use and successful deployment of a portable, mobile MRI into the acute stroke setting. In current practice, all patients, including those that are critically ill, must be transported to a centralized, controlled-access environment to obtain an MRI at a single time point, in a highly inaccessible paradigm. Our hypothesis is that a highly portable, low-field MRI can be deployed into nearly any setting on a platform that provides real-time, automated neuroimaging analysis. Development of this solution incorporates engineering and technological innovation (low field MRI), methodological innovation (imaging reconstruction techniques, machine learning approaches to automated diagnosis), and conceptual innovation (changing clinical workflow to accommodate a non-invasive method capable of point-of-care and serial MRI). Our key rationale is that we can expand already available treatments, facilitate decision making, and inform new approaches to patient care when we reposition the availability of MRI on a near-universal scale. The fundamental insight is that a low field, portable MRI solution, including advanced methods in image quality, reconstruction, and interpretation, can make imaging available to virtually any patient. We will bring MRI technology and interpretation to an individual patient's bedside and in doing so create a platform for MR imaging and analysis on an unprecedented scale. Because the instrument is inexpensive, does not have cooling requirements and operates on a standard 15A 120V electrical source, project success would democratize diagnostic MR imaging for ischemic and hemorrhagic stroke. In this proposal, we will develop, quantify, and validate the measure of certainty required for transition into clinical care. Stroke has been carefully chosen because of the substantial public health burden and existing treatment options that are available but currently limited because of the requirement for acute neuroimaging. We have developed a highly collaborative and multidisciplinary framework, with leading experts in low field MRI, machine learning, stroke, multicenter studies, clinical and translational research. Embedded as well in our team is the expertise to immediately take this exciting solution to a variety of novel settings (e.g. ambulance, low/middle income countries). Our industry partner, Hyperfine, is the first company in the world to develop a truly portable MRI solution, in collaboration with our academic team over the last three years. As we prospectively develop, troubleshoot, and fine-tune our solution at two leading institutions (Yale and MGH), we have assembled a broad scientific team to incorporate technological, clinical workflow, and health systems factors so that our solution is ready to deploy in any clinical setting to improve patient care across human health.

摘要