Metabolomic analysis of acute stress hyperglycemia in ischemic stroke

缺血性脑卒中急性应激性高血糖的代谢组学分析

• 批准号: 8224628
• 负责人: William Taylor Kimberly
• 金额: $ 17.88万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8224628
• 关键词: Address; Adult; Blood Glucose; Boston; Brain; Branched-Chain Amino Acids; Caring; Cause of Death; Cerebrovascular Disorders; Clinical; Development; Development Plans; Diabetes Mellitus; Disease; Educational Curriculum; Environment; Fatigue; General Hospitals; Glucose; Goals; Human; Hyperglycemia; Institution; Insulin Resistance; Investigation; Ischemia; Ischemic Stroke; Isoleucine; Knowledge; Leucine; Mass Spectrum Analysis; Massachusetts; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Methods; Nervous System Trauma; Neurological outcome; Neurologist; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Outcome; Patients; Physiological; Play; Prevention; Process; Research; Research Personnel; Research Proposals; Resources; Rodent Model; Role; Science; Stroke; Structure; Surveys; Technology; Time; Transient Ischemic Attack; United States; Valine; acute stress; acute stroke; base; bench to bedside; career; career development; cerebrovascular; disability; glucose metabolism; impaired glucose tolerance; indexing; innovation; metabolic abnormality assessment; metabolomics; novel; novel strategies; patient oriented research; programs; response; skills; treatment strategy

DESCRIPTION (provided by applicant): Dr. W. Taylor Kimberly is a Neurocritical Care and Stroke Neurologist at Massachusetts General Hospital (MGH), whose goal is to become an independent investigator with expertise in metabolomics, insulin resistance and to define its contribution to stroke and other cerebrovascular diseases. His career development plan leverages the resources of a world-class environment by bringing together an outstanding team of investigators centered at a leading academic institution in Boston, Massachusetts General Hospital. Dr. Kimberly has already obtained preliminary results demonstrating the feasibility of research plan that uses a novel metabolomic platform that can analyze more than 300 key metabolites at the same time. Under the mentorship of Dr. Robert Gerszten, and co-Mentors Dr. Greg Sorensen and Dr. Jose Florez, Dr. Kimberly proposes: 1) To determine whether branched chain amino acids are altered in the setting of stroke, 2) To determine whether hyperglycemia of stroke influences the way branched chain amino acids (valine, isoleucine and leucine) are altered, and 3) To prospectively investigate whether glucose metabolism and branched chain amino acid alterations will predict neurological outcomes. The overall goal is to elucidate the mechanisms that underlie hyperglycemia in acute stroke and to determine how this leads to worse neurological outcomes. Bringing together cutting-edge technology and a team with relevant expertise, this project will open new avenues for treatment in stroke. This well-defined patient-oriented research proposal, in concert with mentorship and a structured didactic curriculum, will provide Dr. Kimberly with the skills that are essential for him to develop an independent career in cerebrovascular research at the cutting edge of science. PUBLIC HEALTH RELEVANCE: Despite modern advances in prevention and treatment, stroke remains the leading cause of adult disability and the second leading cause of death worldwide. Dr. Kimberly's proposed career development plan has outstanding potential to advance our knowledge of the interaction between metabolism and ischemic stroke, which is a crucial step towards the discovery of novel treatment strategies.

描述（由申请人提供）：W。Taylor Kimberly博士是马萨诸塞州综合医院（MGH）的神经关闭护理和中风神经科医生，其目标是成为具有代谢组学，胰岛素耐药性专业知识的独立研究者，并定义了其对中风和其他脑血管疾病的贡献。他的职业发展计划通过将一支杰出的调查人员团队汇集在一起​​，该团队集中在马萨诸塞州波士顿的一家领先的学术机构中，来利用世界一流的环境。金伯利博士已经获得了初步结果，证明了研究计划的可行性，该计划使用了一种新型代谢组平台，可以同时分析300多个关键代谢物。在罗伯特·格斯茨（Robert Gerszten）博士的指导下，金伯利（Kimberly）博士格雷格·索伦森（Greg Sorensen）和何塞·弗洛雷斯（Jose Florez）博士，金伯利（Kimberly代谢和分支链氨基酸的改变将预测神经系统结果。总体目标是阐明急性中风高血糖基础的机制，并确定这如何导致神经系统效果较差。将尖端技术和具有相关专业知识的团队汇总在一起，该项目将开辟新的中风治疗途径。这项定义明确的以患者为导向的研究提案与指导和结构化的教学课程一致，将为金伯利博士提供对他在科学尖端领域发展独立职业至关重要的技能。 公共卫生相关性：尽管预防和治疗方面取得了现代的进步，但中风仍然是成人残疾的主要原因和全球第二大死亡原因。金伯利博士提出的职业发展计划具有杰出的潜力，可以促进我们对新陈代谢和缺血性中风之间相互作用的了解，这是迈向发现新型治疗策略的关键一步。