Dye-free, on-demand visualization of blood flow during cerebrovascular surgery
脑血管手术期间血流的无染料、按需可视化
基本信息
- 批准号:10598593
- 负责人:
- 金额:$ 88.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:Anastomosis - actionAneurysmAngiographyAnimal ModelAnimalsArteriovenous malformationBloodBlood Flow VelocityBlood VesselsBlood flowBrainBrain AneurysmsBrain regionBypassCauterizeCerebrovascular systemCirculationClinicalClipCompensationComplexComputer softwareContrast MediaDataDecision MakingDedicationsDiameterDyesEquipmentEvaluationExcisionExtravasationFeedbackGoalsHemorrhageImageImaging technologyIndocyanine GreenInterventionIntravenousLaser Speckle ImagingLegal patentLettersLicensingLogisticsManufacturerMarketingMeasurementMethodsMicroscopeMonitorMoyamoya DiseaseNeurosurgeonOperating RoomsOperative Surgical ProceduresOpticsOryctolagus cuniculusPerformancePerfusionPhasePostoperative PeriodProceduresPublic HealthRattusReadinessReperfusion TherapyResolutionSafetySheepSpecific qualifier valueSterilizationSurgeonSurgical ClipsSurgical ModelsSystemTechniquesTechnologyTestingTimeTissue ViabilityTissuesValidationVariantVascular blood supplyVascularizationVisual FieldsVisualizationanterior cerebral arteryblood flow measurementblood perfusionbrain surgerycerebrovascularcerebrovascular surgeryclinical imagingcommercializationcraniumdata visualizationfirst-in-humanimaging systeminterestmiddle cerebral arterymultiple datasetsneurosurgerynoveloptical imagingpost interventionpreclinical imagingpreservationpreventprototyperevascularization surgerysuccessusability
项目摘要
ABSTRACT
Cerebrovascular surgeons performing delicate surgeries such as aneurysm clipping, arteriovenous malformation
resections, or revascularization procedures could benefit if quantitative information pertaining to the blood flow
status of vessels in their surgical field was made available to them. Current technologies that can monitor blood
flow at high resolution either use complex dedicated equipment or rely on administration of contrast agents, both
of which are disruptive to the surgical procedure and hence, undesired. Dye-based techniques like ICG video-
angiography may not be used frequently and often used only for post-surgical confirmation of surgical success.
We propose a novel method that can noninvasively provide real-time information about blood flow in the
neurosurgeon’s field of view at the spatial scale of microvessels. This modular optical imaging system (called
the CVSurgeONTM) will integrate with existing neurosurgical microscopes in operating rooms providing the
neurosurgeon-user an on-demand video feed of blood flow information to assist in surgical decision-making.
This complementary blood flow information will be obtained using proprietary and licensed laser speckle contrast
imaging technology, and optionally presented to the neurosurgeon in his/her visual field overlaid on the region
of interest. We have previously built a prototype of the system and validated its function in small and large animal
models of reversible and irreversible occlusion of vessels in the brain. Our proposed Phase II project aims to
adapt our technology for clinical use in neurosurgery and then conduct first-in-human studies to validate the
system performance and usefulness in three important types of cerebrovascular surgeries – aneurysm clipping,
cauterization of arteriovenous malformations, and cerebrovascular bypass surgery for moyamoya disease.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Abhishek Rege其他文献
Abhishek Rege的其他文献
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{{ truncateString('Abhishek Rege', 18)}}的其他基金
Ocular Blood Flow Imaging for Glaucoma Assessment
用于青光眼评估的眼血流成像
- 批准号:
10483638 - 财政年份:2022
- 资助金额:
$ 88.3万 - 项目类别:
Ocular Blood Flow Imaging for Glaucoma Assessment
用于青光眼评估的眼血流成像
- 批准号:
10617379 - 财政年份:2022
- 资助金额:
$ 88.3万 - 项目类别:
Ocular Blood Flow Imaging for Glaucoma Assessment
用于青光眼评估的眼血流成像
- 批准号:
10867973 - 财政年份:2022
- 资助金额:
$ 88.3万 - 项目类别:
Dye-free, on-demand visualization of blood flow during cerebrovascular surgery
脑血管手术期间血流的无染料、按需可视化
- 批准号:
10483677 - 财政年份:2022
- 资助金额:
$ 88.3万 - 项目类别:
Assessment of episcleral vasculature for glaucoma management
青光眼治疗中巩膜外层血管系统的评估
- 批准号:
10324938 - 财政年份:2021
- 资助金额:
$ 88.3万 - 项目类别:
Development of Flow Based Biomarkers for Retinopathy of Prematurity - Supplemental Aim
基于流的早产儿视网膜病变生物标志物的开发 - 补充目标
- 批准号:
10098795 - 财政年份:2019
- 资助金额:
$ 88.3万 - 项目类别:
Laser Speckle Imaging Chip for Telehealth Applications
用于远程医疗应用的激光散斑成像芯片
- 批准号:
9466379 - 财政年份:2014
- 资助金额:
$ 88.3万 - 项目类别:
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