ENIGMA Bipolar Initiative: A Global Study of Imaging Genomics & Clinical Outcomes

ENIGMA 双极倡议:影像基因组学的全球研究

基本信息

  • 批准号:
    10598611
  • 负责人:
  • 金额:
    $ 58.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Bipolar disorder (BD) is a devastating and poorly understood illness. Its burden exceeds $202 billion a year in direct treatment, societal and family costs. With no known cure and limited therapeutic options, 50% of patients attempt suicide at least once; up to 30% of patients do not respond to first-line treatment - even with the latest medications and psychosocial therapy - yet bipolar disorder has only received a small fraction of the amount of research attention that goes into serious non-psychiatric illness. Differentiating BD from major depression is crucial for understanding BD pathophysiology. Advances in imaging are beginning to offer the first detailed, reproducible, and reliable data on brain changes in BD and how they progress, but the lack of global initiatives in bipolar disorder has stalled research. The high cost of data collection - few studies scan more than a hundred patients - has led to underpowered studies whose findings often fail to replicate, cannot adequately model confounds, and often lack power to identify factors that modulate disease progression or recovery. Our ENIGMA Bipolar Initiative offers a new, cost-effective, innovative global approach - a new source of power to unblock this logjam by merging resources, capital infrastructure and talents of leading BD centers including data from 48 cohorts across the world. ENIGMA’s Global Alliance for Worldwide Imaging Genomics in Bipolar Disorder - builds on our thriving ENIGMA Consortium. ENIGMA’s approach merges data from tens of thousands of individuals and “gives us a power we have not had”, and is “breaking the logjam in neuroscience” (New York Times). The Lancet hailed ENIGMA as “Crowdsourcing meets Neuroscience”. In designing the ENIGMA-Bipolar initiative, we identified the most productive activities in the ENIGMA Bipolar working group, and organized them into 3 themes - imaging, genomics, and cross-disorder comparisons. This global initiative tackles key questions in BD: how does the illness affect the brain? What imaging and genomic biomarkers assist diagnosis, monitor treatment, and predict outcomes? How do BD genetic susceptibility loci affect the brain? With global data and expert teams from 15 countries (see Support Letters), we tackle imaging, genomic, and predictive questions about BD with unprecedented power. Across Brazil, Japan, the US, Canada, Norway, The Netherlands, Germany, France, Australia, and South Africa - what brain differences do we reproducibly detect in BD (with structural/diffusion MRI, connectomics and resting state fMRI)? How do they vary across life, with illness duration, by demographics, in women versus men, by age of onset, subtype and treatment? Using ENIGMA’s harmonized protocols, we will analyze the largest collection of multisite neuroimaging data in BD - diverse in age, ethnicity, treatment response - to track disease worldwide. In a new Cross-Disorder partnership of ENIGMA-BD and MDD, we use ENIGMA’s data-driven models to detect imaging and genomic biomarkers to distinguish the 2 disorders and identify subtypes. After harmonizing data elements across disorders, we will create a ranked list of actionable factors that affect prognosis in BD.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Ole A Andreassen其他文献

Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation
按时间表达模式对精神分裂症基因进行聚类有助于功能解释
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    6.6
  • 作者:
    D. van der Meer;W. Cheng;J. Rokicki;Sara Fernandez;Alexey Shadrin;O. Smeland;Friederike Ehrhart;Sinan Gülöksüz;L. Pries;Bochao Lin;Bart P F Rutten;J. van os;M. O’Donovan;A. Richards;N. Steen;S. Djurovic;L. Westlye;Ole A Andreassen;T. Kaufmann
  • 通讯作者:
    T. Kaufmann
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
全基因组分析揭示了 MAPT、MOBP 和 APOE 位点在散发性额颞叶痴呆中的潜在作用。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Claudia Manzoni;D. Kia;Raffaele Ferrari;G. Leonenko;Beatrice Costa;Valentina Saba;Edwin Jabbari;M. Tan;D. Albani;V. Álvarez;Ignacio Alvarez;Ole A Andreassen;Antonella Angiolillo;A. Arighi;Matt Baker;L. Benussi;V. Bessi;G. Binetti;Daniel J. Blackburn;Mercè Boada;B. Boeve;S. Borrego;B. Borroni;G. Bråthen;W. Brooks;A. C. Bruni;P. Caroppo;S. Bandres;J. Clarimón;R. Colao;C. Cruchaga;Adrian Danek;Sterre C. M. de Boer;I. de Rojas;A. Di Costanzo;Dennis W. Dickson;J. Diehl‐Schmid;Carol Dobson;O. Dols;Aldo Donizetti;E. Dopper;Elisabetta Durante;C. Ferrari;G. Forloni;F. Frangipane;Laura Fratiglioni;M. Kramberger;Daniela Galimberti;Maurizio Gallucci;P. García;R. Ghidoni;G. Giaccone;Caroline Graff;N. Graff;Jordan Grafman;Glenda M Halliday;Dena G. Hernandez;L. Hjermind;John R. Hodges;G. Holloway;E. Huey;I. Illán;K. Josephs;D. Knopman;M. Kristiansen;John B. Kwok;I. Leber;H. Leonard;Ilenia Libri;A. Lleó;Ian R. A. Mackenzie;G. Madhan;R. Maletta;M. Marquié;A. Maver;M. Menéndez;Graziella Milan;Bruce L. Miller;Christopher M. Morris;Huw R. Morris;B. Nacmias;J. Newton;Jørgen E. Nielsen;Christer Nilsson;V. Novelli;Alessandro Padovani;S. Pal;F. Pasquier;P. Pástor;Robert Perneczky;B. Peterlin;R. C. Petersen;Olivier Piguet;Y. Pijnenburg;A. Puca;R. Rademakers;I. Rainero;L. Reus;A. Richardson;Matthias Riemenschneider;E. Rogaeva;Boris Rogelj;S. Rollinson;H. Rosen;G. Rossi;James B. Rowe;E. Rubino;Agustin Ruiz;Erika Salvi;R. Sánchez;S. Sando;A. Santillo;Jennifer A. Saxon;Johannes CM. Schlachetzki;S. Scholz;H. Seelaar;W. Seeley;M. Serpente;S. Sorbi;S. Sordon;Peter St. George;Jennifer C. Thompson;C. van Broeckhoven;V. V. Van Deerlin;S. J. van der Lee;J. V. van Swieten;Fabrizio Tagliavini;J. van der Zee;Arianna Veronesi;Emilia Vitale;M. L. Waldo;Jennifer S. Yokoyama;Mike A Nalls;P. Momeni;Andy Singleton;John Hardy;Valentina Escott
  • 通讯作者:
    Valentina Escott
Improved functional mapping with GSA-MiXeR implicates biologically specific gene-sets and estimates enrichment magnitude
使用 GSA-MiXeR 改进功能图谱,揭示生物特异性基因集并估计富集程度
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    O. Frei;G. Hindley;A. Shadrin;D. Meer;B. Akdeniz;W. Cheng;K. S. O'Connell;S. Bahrami;N. Parker;O. Smeland;Dominic;Holland;C. D. Leeuw;D. Posthuma;Ole A Andreassen;A. M. Dale
  • 通讯作者:
    A. M. Dale
F49. EPIGENETIC MODULATION OF THE EFFECT OF WINTER BIRTHS IN SCHIZOPHRENIA AND BIPOLAR DISORDER
F49. 精神分裂症和双相情感障碍中冬季出生影响的表观遗传调节
  • DOI:
    10.1016/j.euroneuro.2023.08.437
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
    6.700
  • 作者:
    Ustat Bedi;Anne-Kristin Stavrum;Ingrid Melle;Ole A Andreassen;Stephanie Le Hellard
  • 通讯作者:
    Stephanie Le Hellard
W21. GENETIC OVERLAP OF SEVERE PSYCHIATRIC DISORDERS WITH LUNG FUNCTION AND ASTHMA SUGGESTS SHARED BIOLOGICAL MECHANISMS
严重精神障碍与肺功能和哮喘的遗传重叠表明存在共同的生物学机制
  • DOI:
    10.1016/j.euroneuro.2024.08.230
  • 发表时间:
    2024-10-01
  • 期刊:
  • 影响因子:
    6.700
  • 作者:
    Zheng-An Lu;Alexander Ploner;Piotr Jaholkowski;Alexy Shadrin;Bronwyn Haasdyk;Ole A Andreassen;Sarah Bergen
  • 通讯作者:
    Sarah Bergen

Ole A Andreassen的其他文献

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{{ truncateString('Ole A Andreassen', 18)}}的其他基金

3/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact
3/7 精神病学基因组学联盟:推进发现和影响
  • 批准号:
    10380568
  • 财政年份:
    2021
  • 资助金额:
    $ 58.95万
  • 项目类别:
3/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact
3/7 精神病学基因组学联盟:推进发现和影响
  • 批准号:
    10611848
  • 财政年份:
    2021
  • 资助金额:
    $ 58.95万
  • 项目类别:

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