A 0.5 mm resolution total-body small-animal PET

分辨率为 0.5 毫米的小动物全身 PET

• 批准号: 10598107
• 负责人: Junwei Du
• 金额: $ 63.88万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598107
• 关键词: Animals; Anodes; Aorta; Area; Biochemical; Biological Assay; Biological Models; Biological Monitoring; Biological Process; Brain; Brain imaging; Breast Microcalcification; Cathodes; Cells; Coupled; Dedications; Development; Diameter; Disease model; Electronics; Evaluation; Event; Funding; Glues; Goals; Human; Hybrids; Image; Imaging Techniques; Inflammation; Length; Light; Lutetium; Magnetic Resonance Imaging; Measurement; Methods; Mus; Optics; Outcome; Output; Performance; Perfusion; Physiological; Polishes; Positioning Attribute; Positron-Emission Tomography; Protocols documentation; Resolution; Signal Transduction; Silicon; Structure; Study models; System; Technology; Thick; Time; Work; Yttrium; cost; data acquisition; design; detector; fabrication; image translation; imaging modality; improved; in vivo; kinetic model; meter; molecular imaging; mouse model; nanomolar; parametric imaging; photomultiplier; pre-clinical; pre-clinical research; preclinical imaging; preclinical study; radiotracer; temporal measurement; tool; ultraviolet

Summary The key parameters of small-animal positron emission tomography (PET) are its spatial resolution and sensitivity that determine the ability to image and quantify radiotracers in a small region of the subject at sub-nanomolar concentrations. However, the applications of small-animal PET have been limited in its application by a combination of spatial resolution and sensitivity, which hampers the use of PET for a range of applications including mouse brain imaging, aortic microcalcification and inflammation imaging, high-resolution total-body dynamic imaging and kinetic modeling studies with using image-derived input function. The goals of this proposal are 1) to develop a 0.5 mm resolution total-body small-animal PET scanner dedicated for high-resolution and fast dynamic applications for imaging mouse disease models, and 2) provide a pre-clinical tool using mouse models to develop, validate, characterize the paradigms and protocols that will feed into human studies, such as total-body and brain studies. The proposed PET scanner will have 128 depth-of-interaction (DOI) detectors. The ring diameter and the axial length are 110 mm and 167 mm, respectively, which is designed to cover the entire body of the mouse and to obtain high resolution and high sensitivity across the entire body. Dual-ended readout detectors based on linearly-graded silicon photomultipliers (LG-SiPMs) coupled to both ends of 40 x 40 lutetium yttrium oxyorthosilicate (LYSO) arrays with a pitch size of 0.5 mm and length of 20 mm will be used to extract DOI information to maintain high and uniform spatial resolution across the entire body of the mouse. LYSO is chosen due to its high light yield (for high spatial resolution and energy resolution), high stopping power (for high sensitivity), and fast decay time (high event rate ability). Dedicated data acquisition electronics for dual-ended readout detectors will be designed for the proposed scanner by upgrading our well-studied electronics system, and a signal multiplexing readout method will be used to reduce the 40 signals of each detector to 9 signals (8 for position information and 1 for timing information) to reduce the cost, complexity, and heat of the readout electronics. The outcome of this proposal will be a total-body small animal PET scanner with a resolution < 0.5 mm and a sensitivity ~24.5 % at the center of the field of view. The resolution will be ~0.5 mm and the sensitivity will be better than 15 % across the volume of the mouse. The spatial/volume resolution is more than 2x/8x better than currently available small-animal PET scanners with similar sensitivity, and the sensitivity is more than 20x better than currently available small-animal PET scanners with similar resolution. The proposed scanner can promote the use of total-body small-animal PET for monitoring biological processes that result in fine structures and expand the range of applications for this powerful, in vivo, non-invasive and translational imaging modality in preclinical applications. The PET scanner developed in this proposal is also MRI-compatible and will support eventual integration inside an MRI scanner for hybrid PET/MRI imaging.

概括 小动物正电子发射断层扫描（PET）的关键参数是其空间分辨率和灵敏度 这决定了在亚纳米摩尔处受试者的小区域中成像和定量放射性示例的能力 浓度。但是，小动物宠物的应用在其应用中受到限制 空间分辨率和敏感性的结合，这阻碍了PET在一系列应用中的使用 包括小鼠脑成像，主动脉微广告和炎症成像，高分辨率总体型 使用图像衍生的输入函数进行动态成像和动力学建模研究。 该提案的目标是1）制定0.5毫米的分辨率总体小动物pet扫描仪专用 用于成像小鼠疾病模型的高分辨率和快速动态应用，2）提供临床前 使用鼠标模型来开发，验证，表征将进食人类的范例和协议的工具 研究，例如全身和大脑研究。拟议的PET扫描仪将具有128个间隔 （doi）探测器。环直径和轴向长度分别为110毫米和167毫米 覆盖小鼠的整个身体，并在整个身体中获得高分辨率和高灵敏度。 基于线性级级的硅光电层面（LG-SIPMS）的双端读数检测器与两端耦合 40 x 40 lutetium yttrium oxyorthosilicate（lyso）阵列，音高大小为0.5 mm，长度为20 mm 用于提取DOI信息，以维持整个身体的高空间分辨率 老鼠。由于其高光的产量（对于高空间分辨率和能量分辨率），因此选择了Lyso，高停止 功率（用于高灵敏度）和快速衰减时间（高事件速率能力）。 专用数据采集电子设备将为拟议 扫描仪通过升级我们良好的电子系统，并将使用信号多路复用方法 将每个检测器的40个信号降低到9个信号（用于位置信息的8个信号，1个定时信息）至 降低电子设备的成本，复杂性和热量。 该提案的结果将是一个全身小动物宠物扫描仪，分辨率<0.5 mm和a 敏感性〜在视野中心的24.5％。分辨率为〜0.5 mm，灵敏度将为 在整个小鼠的体积中，大于15％。空间/音量分辨率大于2x/8x 目前可用的具有相似灵敏度的小动物宠物扫描仪，灵敏度高于20倍以上 比目前可用的小动物宠物扫描仪具有相似的分辨率。拟议的扫描仪可以促进 使用总体体小动物宠物来监测生物学过程，从而导致精细结构和 扩展这种功能强大的体内，无创和转化成像模式的应用程序范围 临床前应用。该提案中开发的PET扫描仪也与MRI兼容，并将支持 最终集成在MRI扫描仪中用于混合宠物/MRI成像。