Force-Based Manipulations Research Network

摘要 尽管存在大量的机械感觉知识，但我们目前对机械感觉的理解与机械感觉之间的协同作用， 感觉机械传导和基于力的操纵（FBM）机制跨研究学科 仍然非常有限。这些研究领域之间缺乏协同作用已被证明是一个可怕的问题。 FBM的发展和治疗优化的障碍。加速跨学科合作 研究和推进FBM领域，我们的目标是建立国家/国际学术和专业 基于力的操纵网络（ForceNet）。“力网”的任务是成功地克服 长期存在的障碍涉及：1）缺乏通用的FBM部队相关指标，2）缺乏FBM 机械知识（包括机械敏感受体，神经元和回路如何在病理过程中改变） 条件），和3）未定义的，但潜在的重要作用的背景因素对FBM机制。到 为了实现我们的网络目标，我们将在生理学的交叉点上促进跨学科研究， 生物力学、大数据/人工智能、神经科学、免疫学、成像和心理学， 临床和临床相关研究，解决了所施加的力的FBM指标， FBM机械转导和FBM背景效应。ForceNet将强调开发新的 跨学科合作和提交新的实验和翻译临床前试点 项目这些试点项目将包括基本的理论框架和转换设计，主要 和二次分析，新的和辅助项目，并将开放给整个学术研究人员 职业光谱ForceNet旨在发展FBM员工队伍并使其多样化，开发新的FBM管道 跨学科的研究人员，并鼓励更大的研究密集型公众之间的新的合作 大学和较小的中西医结合机构。ForceNet将使用各种途径来创建和 分享新的FBM知识和资源，包括进行FBM德尔菲研究，在 手册和手法治疗杂志的特刊，举办面对面和虚拟研讨会， 网络研讨会，创建一个互动网站，ForceNet成员可以在其中找到未来的跨学科 合作者，并使用社交媒体来推广和共享网络资源。试点补助金获得者将出席 他们的研究成果在我们的年度ForceNet研讨会，旨在鼓励新的跨学科FBM 合作。为了在资助期结束后维持ForceNet网络的增长，我们将建立ForceNet “特殊兴趣小组”、卫星活动以及在2005年举行的大型国家/国际科学会议上的社会活动。 ForceNet成员定期参加和/或担任领导职务。作为目前该领域的领导者 基础和临床FBM研究，提供给ForceNet领导团队的资源沿着我们的 高度知名的机构和跨学科合作者建立的个人网络使我们的建议 很好地定位于在未来几十年内对FBM机制研究和临床护理产生重大影响。

ABSTRACT Whereas a large body of mechanosensation knowledge exists, synergy between our current understanding of sensory mechanotransduction and Force-Based Manipulations (FBM) mechanisms across research disciplines remains severely limited. This lack of synergy between these research fields has proven to be a formidable barrier to the advancement and therapeutic optimization of FBM. To accelerate interdisciplinary collaborative research and advance the FBM field, we aim to establish a national/international academic and professional Force-Based Manipulation network (ForceNet). The charge of ForceNet will be to successfully overcome the long-established barriers pertaining to: 1) the lack of universal FBM force-related metrics, 2) the lack of FBM mechanistic knowledge (including how mechanosensitive receptors, neurons, and circuits change in pathological conditions), and 3) the undefined but potentially important role of contextual factors on FBM mechanisms. To accomplish our Network goals, we will stimulate interdisciplinary research at the intersections of physiology, biomechanics, big data/artificial intelligence, neuroscience, immunology, imaging and psychology emphasizing clinical and translationally relevant research addressing FBM metrics of applied force, neural mechanisms of FBM mechanotransduction, and FBM contextual effects. ForceNet will emphasize the development of new interdisciplinary collaborations and the submission of novel experimental and translational pre-clinical pilot projects. These pilot projects will encompass basic, theoretical framework, and translational designs, primary and secondary analyses, new and ancillary projects, and will be open to investigators across the entire academic career spectrum. ForceNet aims to grow and diversify the FBM workforce, develop a pipeline of new FBM interdisciplinary investigators, and encourage new collaborations between larger research-intensive public universities and smaller Integrative Medicine institutions. ForceNet will use a variety of avenues to create and share new FBM knowledge and resources including performing a FBM Delphi Study, publishing 6-10 articles in a special issue of Journal of Manual and Manipulative Therapy, hosting face-to-face and virtual, workshops, webinars, creating an interactive website where ForceNet members can locate future interdisciplinary collaborators, and using social media to promote and share Network resources. Pilot grant awardees will present their research findings at our annual ForceNet workshops, designed to encourage new interdisciplinary FBM collaborations. To sustain ForceNet network growth after the funding period ends, we will establish ForceNet “special interest groups”, satellite events, and social events at large national/international scientific meetings in which ForceNet members attend regularly and/or serve in a leadership capacity. As current leaders in the field of basic and clinical FBM research, the resources provided to the ForceNet Leadership Team along with our highly visible institutions and established personal networks of interdisciplinary collaborators makes our proposal well positioned to substantially impact FBM mechanistic research and clinical care for decades to come.