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Mechanics and Devices

机械与装置

基本信息

批准号：
10612116
负责人：
MICHAEL REGNIER
金额：
$ 25.32万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-05 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10612116
关键词：
3D Print Address Aerobic Animal Model Animals Arthrogryposis Assessment tool Biochemical Biological Assay Biopsy Biopsy Specimen Cells Center for Translational Science Activities Clinic Collaborations Collecting Cell Computer software Contractile Proteins Contracture Coupled Cues Development Devices Disease Distal Educational workshop Embryo Engineering Environment Environmental Impact Faculty Fibroblasts Filament Functional disorder Generations Genetic Goals Histologic Human Individual Injury Interdisciplinary Study Ischemia Kinetics Measures Mechanics Metabolic Metabolism Microfabrication Mitochondria Modeling Molecular Molecular Target Muscle Muscle Cells Muscle Development Muscle Fibers Muscle function Muscular Dystrophies Myofibrils Myopathy NCI Center for Cancer Research Nature Operative Surgical Procedures Organ Pathology Pathway interactions Pediatric Hospitals Pharmaceutical Preparations Pharmacologic Substance Postdoctoral Fellow Preparation Property Proteins Proteomics Protocols documentation Rapid screening Relaxation Research Research Personnel Resources Sampling Skeletal Muscle Skin Source Structure Techniques Testing Therapeutic Tissue Engineering Tissue Therapy Tissue constructs Tissues Training Urine Work base cellular engineering clinical application clinical investigation commercialization experimental study fetal gene therapy graduate student high throughput screening human disease human stem cells indexing induced pluripotent stem cell instrumentation investigator training novel novel therapeutic intervention preclinical study regenerative cell sarcopenia skills small molecule stem cell differentiation stem cells success tool

项目摘要

ABSTRACT – Core B The goals of Core B is to provide 1) state of the art instrumentation and other resources to investigators studying skeletal muscle development and diseases, 2) assays for maturation of early stage muscle cells, and 3) testing and developing novel therapeutic interventions. The Core has instrumentation to assess contractile function at the protein, filament, cell, tissue and organ levels, and assays for measuring the developing properties of early stage muscle from animal and human sources such as inducible pluripotent stem cell derived muscle cells. The Core will train investigators individually and with workshop, and work with them to develop novel research assays for drug and small molecule testing, and investigating engineered cells and tissues and gene therapies that are being developed for clinical application and commercialization.

摘要-核心B 核心B的目标是：1）为研究者提供最先进的仪器和其他资源研究骨骼肌发育和疾病，2）早期肌细胞成熟的测定，和 3)测试和开发新的治疗干预措施。核心有工具来评估收缩在蛋白质、丝、细胞、组织和器官水平上的功能，以及用于测量发育中的来自动物和人类来源的早期肌肉的性质，例如诱导性多能干细胞衍生的肌肉细胞。核心小组将对调查人员进行单独培训和举办讲习班，并与他们合作，开发用于药物和小分子测试的新型研究分析，并研究工程细胞，组织和基因疗法正在开发用于临床应用和商业化。