Bioengineering Cardiovascular Training Grant (BCTG)

摘要 生物工程心血管训练补助金(BCTG)计划为六个NIH提供生物工程训练 支持和一个生物工程系支持致力于心血管领域职业的博士生 研究。心血管疾病是美国死亡的主要原因，在这一领域取得了进展 将需要培养具有不同生物工程背景的杰出科学家，以开发新的和 研究、诊断和治疗心血管疾病的创新方法。威斯康星州大学和教育部 50多年来，生物工程一直是CV研究和技术开发的领先者。BCTG教职员工 在工程学院和医学院的多个系都有很强的协作计划 在这片区域。我们的计划通过培训基础科学和翻译研究方面的专业人员而造福于公众 将工程、数学、化学、生理学、物理学和计算技能相结合，以促进 基础发现和开发新技术。学生获得跨学科技能和 协作。该计划强调诊断和治疗方面的新技术开发以供研究 并治疗心血管疾病，改善早期发现和疾病管理，以提高心脏的生活质量 失败的病人。我们认为，翻译研究的成功需要训练有素的科学家成为 在学术界和工业界都有一席之地，拥有成功将研究从大学转化为 商业化和临床。对于此续订提案，我们添加了几个新的组件，以提供 研究和专业技能培训，横跨从发现到机械的生物医学管道 从研究到转化性研究再到商业化或临床开发。为期2年的项目涉及1) 在选定导师的实验室进行研究，2)独特的课程，有机会接受临床培训 翻译和商业化，以及3)我们项目独有的临床指导。学员参加 每周一次的研讨会系列，重点是简历研究，并与相关的期刊俱乐部和特别会议 仅限于受训人员的演讲者。受训人员还参加生物医学课程的讲座和讨论小组 研究诚信暑期计划，由医学院赞助。其他新组件包括 向代表性不足的群体提供外联和研究指导，以增加STEM劳动力的多样性 和一个课程，提供资源和研讨会，以促进专业技能发展和培训 研究的重复性、严谨性和透明度。学员的选择是基于很强的量化和 工程背景、教师导师的培训环境、研究是否适合我们 方案重点和创新、协作和转化研究的潜力。出席的受训人员 在年度座谈会和全国会议上，并撰写包括反馈问题的年度进展报告 不断改进我们的计划。学员必须在两年结束时申请奖学金。 培训期间，开始建立在获得研究支持方面成功竞争的记录。

ABSTRACT The Bioengineering Cardiovascular Training Grant (BCTG) program provides Bioengineering training for six NIH supported and one Bioengineering department supported PhD students committed to careers in cardiovascular research. Cardiovascular (CV) diseases are the leading cause of mortality in the US and progress in this area will require training outstanding scientists with a variety of backgrounds in bioengineering to develop new and innovative approaches for study, diagnosis and treatment of CV disease. The UW and Department of Bioengineering have been leaders in CV research and technology development for over 50 years. BCTG faculty in multiple departments in the College of Engineering and School of Medicine have strong collaborative programs in this area. Our program benefits the public by training professionals in basic science and translational research that integrates engineering, mathematics, chemistry, physiology, physics and computational skills to promote fundamental discoveries and develop new technologies. Students gain interdisciplinary skills and the value of collaboration. The program emphasizes new technology development in diagnostics and therapeutics to study and treat CV pathologies, improving early detection and disease management, to improve quality of life for heart failure patients. We believe that the success of translational research requires highly trained scientists to be placed in both academia and industry, with skills to successfully transition research from universities to commercialization and the clinic. For this renewal proposal we have added several novel components to provide training in research and professional skills that spans the biomedical pipeline from discovery & mechanistic studies to translational research to commercialization or clinical development. The 2-year program involves 1) research in the laboratory of a chosen mentor, 2) a unique curriculum with opportunities for training in clinical translation and commercialization, and 3) clinical preceptorships that are unique to our program. Trainees attend a weekly seminar series focused on CV research, with an associated journal club and special sessions with speakers that are limited to trainees. Trainees also attend lectures and discussion groups in the Biomedical Research Integrity summer program, sponsored by the School of Medicine. Additional new components include outreach and research mentoring to under-represented groups to increase the diversity of the workforce in STEM fields, and a course that provides resources and seminars for professional skills development and training in research reproducibility, rigor and transparency. Trainees are selected based on strong quantitative and engineering backgrounds, training environment of faculty mentors, appropriateness of the research to our programmatic focus and the potential for innovative, collaborative and translational research. Trainees present at yearly symposiums and national meetings, and write a yearly progress report that includes feedback questions to continually improve our program. Trainees are required to apply for fellowships at the end of the two-year training period to begin establishing a record of successful competition in gaining research support.