UAB-MISS MACS/WIHS Combined Cohort Study

UAB-MISS MACS/WIHS 联合队列研究

基本信息

批准号：
10612358
负责人：
James Benjamin Brock
金额：
$ 291.84万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612358
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Advisory Committees Age Aging Alabama Area Award Back Behavioral Cardiovascular Diseases Cardiovascular system Caring Chronic Chronic Disease Clinical Research Cohort Studies Collaborations Communication Communities Community Outreach Country Data Data Analyses Deep South Development Disease Education Enrollment Ensure Epidemic Epidemiology Genetic Genetic Determinism HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV vaccine HIV/AIDS HIV/STD Health Health Disparities Research Health Services Accessibility Heart Human immunodeficiency virus test Immune Immunogenetics Income Infection Inflammation Institution Jackson Heart Study Knowledge Leadership Link Malignant Neoplasms Medical center Mental Health Mentors Minority Mississippi Modernization Neurocognition Newly Diagnosed Obesity Outcome Pathogenesis Patient Care Patients Persons Phenotype Population Positioning Attribute Poverty Areas Prevalence Prevention Research Productivity Protocols documentation Race Recording of previous events Records Research Research Personnel Resources Rural Rural Population STI prevention Scientist Services Site Socioeconomic Status Specimen Study Subject System T-Lymphocyte United States United States National Institutes of Health Universities Viral Viral Load result Visit Woman Zoonoses antiretroviral therapy black men who have sex with men black women cancer care clinical care clinical practice cohort comorbidity cost effectiveness data centers data quality data sharing evidence base experience health care disparity health disparity immune activation innovation men minority investigator mortality outreach protocol development psychosocial recruit response sample collection social stigma stomach cardia structural determinants translational scientist treatment research vaccine development working group

项目摘要

As the HIV epidemic has matured, understanding the impact of HIV on overall health becomes more important as HIV is managed as a chronic illness. This is particularly true in the Southeastern part of the United States, where the epidemic is worsening relative to other parts of the country. Alabama and Mississippi are located in the heart of the Deep South and have some of the highest rates of new HIV cases annually, especially among minorities. Barriers to access to care are among the worst in the US, and the prevalence of obesity, cardiovascular disease, cancer, and health care disparities are most pronounced. Therefore, studying people living with HIV in the Deep South will provide the opportunity to understand the current epidemic as it is emerging today. The University of Alabama at Birmingham (UAB) has a rich tradition of AIDS research, dating back to the mid-1980s. As the epidemic has matured, UAB scientists have established expertise in many areas, including psychosocial/behavioral, neurocognition, aging, cancer, pathogenesis, and health disparities. UAB scientists have emerged as leaders in innovative cohort research that evaluates the long-term outcomes via multisite cohort studies (e.g., CNICS, NA-ACCORD, ART-CC, and FRAM). By creating a linkage to the University of Mississippi Medical Center (UMMC) as a subaward partner, we take full advantage of their years of expertise in HIV clinical care, outreach, and cohort research. Collectively, we represent an ideal cohort for the MACS/WIHS Combined Cohort Study (CCS), both in terms of scientific expertise and representation of the current HIV epidemic in the US. The Specific Aims for our CCS site are: 1. To continue to provide scientific leadership and expertise within the CCS, focusing on psychosocial/behavioral, structural and genetic determinants of HIV and co-morbidity-related outcomes; neurocognition among aging PLWH; and immunopathogenesis of HIV disease. 2. To collect high-quality data and specimens from MACS/WIHS-CCS core and sub-study visits to contribute to the Unified Scientific Agenda (USA) and protocols; and collaborate with the overall team of MACS/WIHS-CCS investigators across sites. 3. To continue to achieve operational excellence by maintaining outstanding records for recruitment, retention, data quality and completeness and cost-effectiveness. 4. To ensure sharing of data/specimens with the data center, the NIH community and external investigators, and communication/engagement with local communities. 5. To develop, mentor and support junior and minority investigators in coordination with Developmental Award Advisory Committee (DARC). 6. To recruit and retain a cohort of 230 women and 270 men, HIV-positive and age-matched HIV- negative controls, who are strategically selected to enable the conduct of the USA.

随着艾滋病毒流行的成熟，了解艾滋病毒对整体健康的影响变得越来越重要由于艾滋病毒被视为一种慢性疾病。在美国东南部，尤其如此相对于该国其他地区的流行病正在恶化。阿拉巴马州和密西西比州位于在深南方的中心，每年有一些新的艾滋病毒案例，尤其是在少数民族中。进入护理的障碍是美国最糟糕的障碍，肥胖症的流行率是心血管疾病，癌症和医疗保健差异最为明显。因此，学习人在南方深处生活的艾滋病毒将提供理解当前流行病的机会今天新兴。伯明翰阿拉巴马大学（UAB）拥有丰富的艾滋病研究传统，约会回到1980年代中期。随着流行病的成熟，UAB科学家在许多人中建立了专业知识包括社会心理/行为，神经认知，衰老，癌症，发病机理和健康差异的领域。 UAB科学家已经成为创新队列研究的领导者，该研究评估了长期成果通过多站点队列研究（例如CNIC，NA-ACCORD，ART-CC和FRAM）。通过建立与密西西比大学医学中心（UMMC）是亚武士的合作伙伴，我们充分利用了他们的岁月艾滋病毒临床护理，外展和队列研究方面的专业知识。总的来说，我们代表了理想的队列 Mac/WIHS合并队列研究（CCS），无论是在科学专业知识和代表方面美国当前的艾滋病毒流行。我们CCS网站的具体目标是： 1。继续在CCS内提供科学领导和专业知识，重点关注艾滋病毒和合并症相关的心理社会/行为，结构和遗传决定因素结果；衰老的PLWH中的神经认知；和艾滋病毒疾病的免疫发病发生。 2。从Mac/wihs-ccs核心收集高质量的数据和标本有助于统一的科学议程（美国）和协议；并与整体合作 Mac/WIHS-CCS调查人员团队跨站点。 3。通过维护出色的招聘记录，继续实现卓越的运营，保留，数据质量和完整性和成本效益。 4。确保与数据中心，NIH社区和外部共享数据/标本调查人员，以及与当地社区的沟通/互动。 5。发展，指导和支持初级和少数群体调查员与发展奖咨询委员会（DARC）。 6。招募和保留230名女性和270名男性的队列，HIV阳性和年龄匹配的HIV- 负面对照，从战略上选择以实现美国的行为。