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UAB-MISS MACS/WIHS Combined Cohort Study

UAB-MISS MACS/WIHS 联合队列研究

基本信息

批准号：
10612358
负责人：
James Benjamin Brock
金额：
$ 291.84万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612358
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Advisory Committees Age Aging Alabama Area Award Back Behavioral Cardiovascular Diseases Cardiovascular system Caring Chronic Chronic Disease Clinical Research Cohort Studies Collaborations Communication Communities Community Outreach Country Data Data Analyses Deep South Development Disease Education Enrollment Ensure Epidemic Epidemiology Genetic Genetic Determinism HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV vaccine HIV/AIDS HIV/STD Health Health Disparities Research Health Services Accessibility Heart Human immunodeficiency virus test Immune Immunogenetics Income Infection Inflammation Institution Jackson Heart Study Knowledge Leadership Link Malignant Neoplasms Medical center Mental Health Mentors Minority Mississippi Modernization Neurocognition Newly Diagnosed Obesity Outcome Pathogenesis Patient Care Patients Persons Phenotype Population Positioning Attribute Poverty Areas Prevalence Prevention Research Productivity Protocols documentation Race Recording of previous events Records Research Research Personnel Resources Rural Rural Population STI prevention Scientist Services Site Socioeconomic Status Specimen Study Subject System T-Lymphocyte United States United States National Institutes of Health Universities Viral Viral Load result Visit Woman Zoonoses antiretroviral therapy black men who have sex with men black women cancer care clinical care clinical practice cohort comorbidity cost effectiveness data centers data quality data sharing evidence base experience health care disparity health disparity immune activation innovation men minority investigator mortality outreach protocol development psychosocial recruit response sample collection social stigma stomach cardia structural determinants translational scientist treatment research vaccine development working group

项目摘要

As the HIV epidemic has matured, understanding the impact of HIV on overall health becomes more important as HIV is managed as a chronic illness. This is particularly true in the Southeastern part of the United States, where the epidemic is worsening relative to other parts of the country. Alabama and Mississippi are located in the heart of the Deep South and have some of the highest rates of new HIV cases annually, especially among minorities. Barriers to access to care are among the worst in the US, and the prevalence of obesity, cardiovascular disease, cancer, and health care disparities are most pronounced. Therefore, studying people living with HIV in the Deep South will provide the opportunity to understand the current epidemic as it is emerging today. The University of Alabama at Birmingham (UAB) has a rich tradition of AIDS research, dating back to the mid-1980s. As the epidemic has matured, UAB scientists have established expertise in many areas, including psychosocial/behavioral, neurocognition, aging, cancer, pathogenesis, and health disparities. UAB scientists have emerged as leaders in innovative cohort research that evaluates the long-term outcomes via multisite cohort studies (e.g., CNICS, NA-ACCORD, ART-CC, and FRAM). By creating a linkage to the University of Mississippi Medical Center (UMMC) as a subaward partner, we take full advantage of their years of expertise in HIV clinical care, outreach, and cohort research. Collectively, we represent an ideal cohort for the MACS/WIHS Combined Cohort Study (CCS), both in terms of scientific expertise and representation of the current HIV epidemic in the US. The Specific Aims for our CCS site are: 1. To continue to provide scientific leadership and expertise within the CCS, focusing on psychosocial/behavioral, structural and genetic determinants of HIV and co-morbidity-related outcomes; neurocognition among aging PLWH; and immunopathogenesis of HIV disease. 2. To collect high-quality data and specimens from MACS/WIHS-CCS core and sub-study visits to contribute to the Unified Scientific Agenda (USA) and protocols; and collaborate with the overall team of MACS/WIHS-CCS investigators across sites. 3. To continue to achieve operational excellence by maintaining outstanding records for recruitment, retention, data quality and completeness and cost-effectiveness. 4. To ensure sharing of data/specimens with the data center, the NIH community and external investigators, and communication/engagement with local communities. 5. To develop, mentor and support junior and minority investigators in coordination with Developmental Award Advisory Committee (DARC). 6. To recruit and retain a cohort of 230 women and 270 men, HIV-positive and age-matched HIV- negative controls, who are strategically selected to enable the conduct of the USA.

随着艾滋病毒流行的成熟，了解艾滋病毒对整体健康的影响变得更加重要因为艾滋病毒是作为一种慢性疾病来管理的。在美国东南部尤其如此，与该国其他地区相比，该地区的疫情正在恶化。阿拉巴马州和密西西比州位于位于南方腹地的中心地带，每年新发艾滋病毒病例率最高，尤其是少数民族之间。获得医疗服务的障碍是美国最严重的障碍之一，而且肥胖症的流行，心血管疾病、癌症和医疗保健方面的差距最为明显。因此，研究人生活在南方腹地的艾滋病毒感染者将提供了解当前流行病现状的机会今天出现。阿拉巴马大学伯明翰分校 (UAB) 拥有丰富的艾滋病研究传统，约会回到20世纪80年代中期。随着疫情的成熟，阿拉巴马大学的科学家们在许多领域建立了专业知识领域，包括心理社会/行为、神经认知、衰老、癌症、发病机制和健康差异。阿拉巴马大学科学家已成为评估长期结果的创新队列研究的领导者通过多中心队列研究（例如 CNICS、NA-ACCORD、ART-CC 和 FRAM）。通过创建到密西西比大学医学中心 (UMMC) 作为子奖励合作伙伴，我们充分利用他们的多年经验艾滋病毒临床护理、外展和队列研究方面的专业知识。总的来说，我们代表了一个理想的群体 MACS/WIHS 联合队列研究 (CCS)，无论是在科学专业知识还是代表性方面美国目前的艾滋病毒流行情况。我们 CCS 站点的具体目标是： 1. 继续在 CCS 内提供科学领导和专业知识，重点关注 HIV 和共病相关的心理社会/行为、结构和遗传决定因素结果；老年感染者的神经认知；和艾滋病毒疾病的免疫发病机制。 2. 从 MACS/WIHS-CCS 核心和子研究访问中收集高质量数据和样本为统一科学议程（美国）和协议做出贡献；并与整体协作各站点的 MACS/WIHS-CCS 调查员团队。 3. 通过保持出色的招聘记录，继续实现卓越运营，保留、数据质量和完整性以及成本效益。 4. 确保与数据中心、NIH 社区和外部共享数据/样本调查人员以及与当地社区的沟通/接触。 5. 与以下机构协调，培养、指导和支持初级和少数族裔研究人员发展奖咨询委员会（DARC）。 6. 招募并留住 230 名女性和 270 名男性，艾滋病毒呈阳性且年龄匹配的艾滋病毒感染者负面控制，他们是经过战略选择以支持美国的行为。