A Multisite Randomized Trial of BattleViro: A Mobile Gaming App to Improve ART Adherence for Youth

BattleViro 的多站点随机试验：一款提高青少年对 ART 依从性的移动游戏应用程序

• 批准号: 10421056
• 负责人: James Benjamin Brock
• 金额: $ 67.58万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-24 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10421056
• 关键词: Accounting; Achievement; Adherence; Administrator; Adolescent and Young Adult; Analysis of Covariance; Behavioral; Biological; Boston; Caring; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Chronic; Clinic; Collaborations; Collection; Control Groups; Data; Development; Devices; Disease; Electronics; Elements; HIV; HIV Infections; HIV/AIDS; Health Benefit; Individual; Information Systems; Intervention; Interview; Knowledge; Life; Measures; Mediator; Medical; Mississippi; Modeling; Motivation; Nature; New England; Participant; Patients; Pharmaceutical Preparations; Play; RNA; Research; Risk; Sample Size; Self Efficacy; Site; Social support; Subgroup; Technology; Testing; Text; Text Messaging; Time; Translating; Treatment Efficacy; United States; Viral Load result; Virus; Youth; absorption; adherence rate; age group; body system; clinical research site; comparative efficacy; comparison control; comparison intervention; data integration; efficacy testing; electronic data; experience; fighting; follow-up; hedonic; improved; mobile application; novel; portability; randomized trial; randomized, controlled study; skills; smartphone application; social engagement; structural determinants; treatment adherence; virtual reality game

Despite need for consistent adherence to medical care, youth living with HIV (YLWH) have low rates of adherence and retention in care, and are at great risk for being lost to follow-up.(5,16-18) There is a great need for adherence interventions that are novel and appealing for YLWH.(7,8,14) We developed, and preliminarily examined, a multi-level technology that integrates a 7-day smart medication device (Wisepill) WITH an immersive and appealing smartphone app/game that is attractive and engaging for YLWH.(82,83) During gameplay, YLWH fight HIV in colorful and immersive organ systems, and receive adherence related text messages with game graphics. Wisepill openings guide game-related text messages and can result in bonus points in the app/game. We tested the Multilevel Gaming Intervention in a developmental trial. The impact of the intervention was greatest among those who had newly begun ART. In participants who had newly begun ART, the intervention decreased viral load and improved ART adherence. Those newly starting ART in the intervention, compared to those newly starting ART in the control, experienced a 0.96 log viral load greater decrease and evidenced a large effect size for improved adherence as measured by Wisepill (d=1.18, 71% vs. 48% adherence at post-test). These interactions between intervention and newly starting ART were significant in ANCOVAs, accounting for baseline values (viral load: F=4.33, p=0.04, adherence: F=3.20, p=0.05). For this next proposed stage of research, we will further test the Multilevel Gaming Intervention with YLWH who are newly starting ART at clinical sites in New England and in Mississippi. A multisite randomized controlled study (48 weeks) among 120 YLWH newly starting ART will test the efficacy of the intervention compared to a control condition (who receive a non-HIV game and the Wisepill) on behavioral and biological measures. Information, Motivation, Behavioral Skills Adherence to ART Immersive iPhone Electronic, portable, 7-day medication game with text organizer/dispenser: measures adherence messaging integrates into iPhone gameHIV RNA Viral Load

尽管需要持续坚持医疗保健，但感染艾滋病毒的青年的感染率很低