Primary Human Airway Cell Culture Core

原代人气道细胞培养核心

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Core D Cell Culture The goal of the work described in this proposal is to collect grow, store and expand airway epithelial cells and smooth muscle cells. These cells will come from bronchoscopic biopsies (brush biopsies for epithelial cells and endobronchial biopsies for smooth muscle cells) from Core B. The main site for collecting, growing and storing the cells will be at IU, but there will be a satellite facility at CWRU to grow cells from bronchoscopies in Cleveland. Subjects will include both severe asthma patients and healthy control subjects. Cells will be provided to investigators from both sites to each or the Projects for use in their Aims, as described. Cells will be catalogued and labeled (by bar code) by study number from Core C. This will allow analysis of the relationship between clinical phenotype, drug response, genotype (for Project 3) and airway cell behavior. Cells will be stored long-term at the IU site. Each sample can be thawed and further expanded for study and testing at the IU site. The ability to collect, expand, and distribute airway epithelial cells to researchers will have a positive impact on understanding and developing therapies for common airway diseases. This will be the only core with these capabilities at either site.
项目总结/摘要 核心D细胞培养 本提案中描述的工作目标是收集、生长、储存和扩增气道上皮细胞 和平滑肌细胞。这些细胞将来自支气管镜活检(上皮细胞刷检)。 细胞和支气管内平滑肌细胞活检)。主要的网站为收集,种植, 储存细胞将在IU,但CWRU将有一个卫星设施, 在克利夫兰做支气管镜检查受试者将包括重度哮喘患者和健康对照 科目细胞将被提供给来自两个研究中心的研究者,以用于他们的目标, 如所描述的。将根据核心C的研究编号对细胞进行分类和标记(通过条形码)。这将 允许分析临床表型、药物应答、基因型(项目3)和 气道细胞行为细胞将长期储存在IU研究中心。每个样品都可以解冻, 在IU研究中心进行研究和检测。收集、扩张和分布气道上皮细胞的能力 研究人员的细胞将对理解和开发常见的治疗方法产生积极的影响。 呼吸道疾病这将是两个站点中唯一具有这些功能的核心。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael D Davis其他文献

Tissue factor expression, regulation, and signaling in human airway cells
人气道细胞中的组织因子表达、调节和信号传导
2019 Year in Review: Asthma
2019 年回顾:哮喘
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Michael D Davis;Craig D Smallwood
  • 通讯作者:
    Craig D Smallwood
Blood Gas Analysis and Hemoximetry 2013
血气分析和血氧测定法 2013
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Michael D Davis;Brian K. Walsh;Ruben D. Restrepo
  • 通讯作者:
    Ruben D. Restrepo
The remaining barriers to normalcy in CF: Advances in assessment of CF lung disease
CF 正常化的剩余障碍:CF 肺部疾病评估的进展
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Heather N Muston;L. Perrem;Michael D Davis;F. Ratjen;C. Ren
  • 通讯作者:
    C. Ren
Real-Time Iterative Monitoring of Radiofrequency Ablation Tumor Therapy with 15O-Water PET Imaging
使用 15O-水 PET 成像实时迭代监测射频消融肿瘤治疗
  • DOI:
    10.2967/jnumed.108.052886
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    9.3
  • 作者:
    A. Bao;B. Goins;G. Dodd;A. Soundararajan;Cristina Santoyo;R. Otto;Michael D Davis;W. Phillips
  • 通讯作者:
    W. Phillips

Michael D Davis的其他文献

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{{ truncateString('Michael D Davis', 18)}}的其他基金

Primary Human Airway Cell Culture Core
原代人气道细胞培养核心
  • 批准号:
    10457994
  • 财政年份:
    2021
  • 资助金额:
    $ 30.26万
  • 项目类别:
Primary Human Airway Cell Culture Core
原代人气道细胞培养核心
  • 批准号:
    10662240
  • 财政年份:
    2021
  • 资助金额:
    $ 30.26万
  • 项目类别:

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空气污染、气候和慢性阻塞性肺病:对加拿大人口的急性和长期影响
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